Brown, Brown L.

Brown, Brown L.
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brownml@evms.edu

selected publications

2007

2-Amino-4-(4-chloro-3-methylphenyl)-5-propyl-1,3-thiazolium iodide. Acta Crystallographica Section E Structure Reports Online. 63:o1598-o1600.
Full Text via DOI: 10.1107/s1600536807009427
2007

Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity.. The Journal of pharmacology and experimental therapeutics. 320:828-36.
Full Text via DOI: 10.1124/jpet.106.111542 PMID: 17090703
2007

Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole.. Molecular pharmacology. 72:132-40.
Full Text via DOI: 10.1124/mol.107.034876 PMID: 17456786
2007

Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools.. Tissue engineering. 13:2561-75.
Full Text via DOI: 10.1089/ten.2007.0023 PMID: 17723106
2006

Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2.. BIOORGANIC & MEDICINAL CHEMISTRY. 14:8366-78.
Full Text via DOI: 10.1016/j.bmc.2006.09.010 PMID: 17035036
2006

Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist.. NEUROPHARMACOLOGY. 50:865-73.
Full Text via DOI: 10.1016/j.neuropharm.2005.12.008 PMID: 16464480
2006

Small molecule inducers of angiogenesis for tissue engineering.. Tissue engineering. 12:1903-13.
Full Text via DOI: 10.1089/ten.2006.12.1903 PMID: 16889520
2006

Voltage-sensitive ion channels and cancer.. Cancer metastasis reviews. 25:493-500.
Full Text via DOI: 10.1007/s10555-006-9017-z PMID: 17111226
2005

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.. BIOCHEMISTRY. 44:11067-73.
Full Text via DOI: 10.1021/bi0508845 PMID: 16101290
2005

Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.. Chemistry & biology. 12:1007-14.
Full Text via DOI: 10.1016/j.chembiol.2005.06.016 PMID: 16183025
2004

Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 21:635-44.
Full Text via DOI: 10.1016/j.ejps.2004.01.004 PMID: 15066664
2004

Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants.. BIOORGANIC & MEDICINAL CHEMISTRY. 12:979-93.
Full Text via DOI: 10.1016/j.bmc.2003.12.011 PMID: 14980611
2004

Novel Angiogenic Compounds for Targeted Drug Delivery. MRS Proceedings. 845:AA5.47.
Full Text via DOI: 10.1557/proc-845-aa5.47
2004

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.. BIOORGANIC & MEDICINAL CHEMISTRY. 12:1029-36.
Full Text via DOI: 10.1016/j.bmc.2003.12.003 PMID: 14980616
2004

Thalidomide analogues demonstrate dual inhibition of both angiogenesis and prostate cancer.. BIOORGANIC & MEDICINAL CHEMISTRY. 12:327-36.
Full Text via DOI: 10.1016/j.bmc.2003.11.007 PMID: 14723953
2004

Thalidomide and analogues: current proposed mechanisms and therapeutic usage.. Clinical prostate cancer. 3:54-61.
Full Text via DOI: 10.3816/cgc.2004.n.014 PMID: 15279692
2003

Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6.. BIOORGANIC & MEDICINAL CHEMISTRY. 11:5545-54.
Full Text via DOI: 10.1016/s0968-0896(03)00525-x PMID: 14642599
2003

Design, synthesis, and development of novel caprolactam anticonvulsants.. BIOORGANIC & MEDICINAL CHEMISTRY. 11:4133-41.
Full Text via DOI: 10.1016/s0968-0896(03)00400-0 PMID: 12927875
2003

Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics.. JOURNAL OF MEDICINAL CHEMISTRY. 46:2494-501.
Full Text via DOI: 10.1021/jm020546r PMID: 12773053
2003

Facile synthesis of an azido-labeled thalidomide analogue.. Organic letters. 5:2865-7.
Full Text via DOI: 10.1021/ol034906w PMID: 12889894
2003

Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers.. Clinical prostate cancer. 2:181-7.
Full Text via DOI: 10.3816/cgc.2003.n.028 PMID: 15040863
2003

Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3.. Molecular cancer therapeutics. 2:1149-54.
PMID: 14617788
2002

Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation.. JOURNAL OF MOLECULAR BIOLOGY. 319:593-602.
Full Text via DOI: 10.1016/s0022-2836(02)00366-2 PMID: 12054857
2001

Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.. JOURNAL OF MEDICINAL CHEMISTRY. 44:531-9.
Full Text via DOI: 10.1021/jm0003642 PMID: 11170643
2000

Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on beta-tubulin.. BIOORGANIC & MEDICINAL CHEMISTRY. 8:1433-41.
Full Text via DOI: 10.1016/s0968-0896(00)00068-7 PMID: 10896120
1999

Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.. JOURNAL OF MEDICINAL CHEMISTRY. 42:1537-45.
Full Text via DOI: 10.1021/jm980556l PMID: 10229624
1997

Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.. JOURNAL OF MEDICINAL CHEMISTRY. 40:602-7.
Full Text via DOI: 10.1021/jm960692v PMID: 9046351
1994

Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.. JOURNAL OF MEDICINAL CHEMISTRY. 37:3289-93.
Full Text via DOI: 10.1021/jm00046a013 PMID: 7932556
1992

Synthesis and conformational analysis of torsionally constrained 1,3,2-dioxaphosphepanes. The Journal of Organic Chemistry. 57:2812-2818.
Full Text via DOI: 10.1021/jo00036a011
1991

Solid-state conformations of medium-sized-ring phosphorus heterocycles: Preparation and x-ray crystal structure of a benzo-fused 1,3,2-dioxaphosphepane in a twist conformation. Heteroatom Chemistry. 2:533-539.
Full Text via DOI: 10.1002/hc.520020505
1990

SOLID-STATE CONFORMATIONS OF MEDIUM-SIZED-RING PHOSPHORUS HETEROCYCLES: X-RAY CRYSTAL STRUCTURES OF TWO NORBORNENE-FUSED 1,3,2-DIOXAPHOSPHEPANES WITH EQUATORIALLY DISPOSED SUBSTITUENTS ON PHOSPHORUS. Phosphorus, Sulfur, and Silicon and the Related Elements. 54:187-196.
Full Text via DOI: 10.1080/10426509008042136

full name

Brown L. Brown

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