Castora, Frank J.

2019

Mitochondrial function and abnormalities implicated in the pathogenesis of ASD. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 83-108.

Full Text via DOI: 10.1016/j.pnpbp.2018.12.015 PMID: 30599156

2019

The T9861C Mutation in the mtDNA-Encoded Cytochrome C Oxidase Subunit III Gene Occurs in High Frequency but with Unequal Distribution in the Alzheimer's Disease Brain. JOURNAL OF ALZHEIMERS DISEASE. 72:257-269.

Full Text via DOI: 10.3233/JAD-190176 PMID: 31561357

2018

A Mathematical Model of Alzheimer's Disease Simulates Different Gene Therapy Treatments and Their Effects on Mitochondrial Activity. Alzheimer's and Dementia Journal.

2018

The MtDNA T9861C Mutation Exacerbates Reductions in Oxidative Phosphorylation Pathways in Alzheimer's Disease Brains. Alzheimer's and Dementia Journal.

2017

Reproductive competency and mitochondrial variation in aged Syrian hamster oocytes. REPRODUCTION FERTILITY AND DEVELOPMENT. 29:1384-1391.

Full Text via DOI: 10.1071/RD15404 PMID: 27327865

2017

A Testable Mathematical Model For Alzheimer's Disease Using Biochemical Systems Theory (BST) Predicts That Mitochondrial Dysfunction Is Linked To Changes In Expression Of Five Genes Impacting Mitochondrial Ros And Apoptosis. Alzheimer's and Dementia Journal.

2017

Brains of Alzheimer's Patients Show Expression Changes in Five Genes Affecting Mitochondrial Morphology, Membrane Potential, and Neuronal Apoptosis that Directly or Indirectly Interact with APP. Alzheimer's and Dementia Journal.

2016

Brains of Alzheimer's Patients Show Expression Changes in Four Genes Affecting Gamma- Secretase and Processing of the Amyloid Precursor Protein. Alzheimer's and Dementia Journal.

2016

Building a testable mathematical model for Alzheimer's Disease using gene expression changes and biochemical systems theory (BST). Alzheimer's and Dementia Journal.

2015

Endometriosis may be associated with mitochondrial dysfunction in cumulus cells from subjects undergoing in vitro fertilization-intracytoplasmic sperm injection, as reflected by decreased adenosine triphosphate production. FERTILITY AND STERILITY. 103:347-352.

Full Text via DOI: 10.1016/j.fertnstert.2014.11.002 PMID: 25516080

2015

Altered expression of mitochondrial energy genes in the brains of Alzheimer's patients can affect secretase gamma regulation and processing of the amyloid precursor protein. Alzheimer's and Dementia Journal.

2013

DOES ENDOMETRIOSIS CAUSE MITOCHONDRIAL DYSFUNCTION IN CUMULUS CELLS? AN IVF STUDY.. FERTILITY AND STERILITY. S371-S371.

2013

Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes. PLOS ONE. 8.

Full Text via DOI: 10.1371/journal.pone.0064955 PMID: 23741435

2012

Quantification of mitochondrial abundance REPLY. FERTILITY AND STERILITY. E19-E19.

Full Text via DOI: 10.1016/j.fertnstert.2012.02.043

2012

An improved procedure for isolation of functional synaptosomes for the transient generation of cybrids from frozen human brain. FASEB JOURNAL.

2012

Structural and energetic changes in mitochondria associated with aging rodent ooctyes may be overcome by mitochondrial microinjection. FASEB JOURNAL.

2012

An improved procedure for isolation of functional synaptosomes for the transient generation of cybrids from frozen human brain. FASEB JOURNAL.

2011

The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation. FERTILITY AND STERILITY. 96:384-388.

Full Text via DOI: 10.1016/j.fertnstert.2011.05.056 PMID: 21683351

2010

MITOCHONDRIAL CHANGES IN AGED OOCYTES AND IMPROVEMENT OF FERTILITY RATE THROUGH AUTOLOGOUS PLATELETS MITOCHONDRIAL MICROINJECTION.. FERTILITY AND STERILITY. S57-S57.

2010

2009

Detection, Quantitation, and Distribution of the T9861C mtDNA Mutation in the Alzheimer's Disease Brain. FASEB JOURNAL.

2009

The effect of aging on the metabolic function and structure of mitochondria in Hamster oocytes. FASEB JOURNAL.

2009

Age-Related Morphologic and Microscopic Variations in Syrian Hamster Ovaries and Oocytes.. BIOLOGY OF REPRODUCTION. 156-157.

2009

Mitochondrial function, quantity and DNA integrity in human oocytes at different stages of maturation. FERTILITY AND STERILITY.

2008

Estrogen receptor alpha (ER alpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium. VIRCHOWS ARCHIV. 453:557-569.

Full Text via DOI: 10.1007/s00428-008-0679-5 PMID: 18853184

2008

Age- associated Morphologic and Metabolic Changes in Mouse and Hamster Oocyte Mitochondria

2008

The mtDNA T9861C mutation occurs in high frequency but with unequal distribution in the Alzheimer's Disease brain. Alzheimer's and Dementia Journal.

2007

Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS): A Case of Mitochondrial Myopathy. Clinical Studies in Medical Biochemistry. Ed. Glenn, R H. Oxford University Press (OUP).

2006

Mutations in mitochondrial-encoded cytochrome c oxidase subunits I, II, and III genes detected in Alzheimer's disease using single-strand conformation polymorphism. ELECTROPHORESIS. 27:398-408.

Full Text via DOI: 10.1002/elps.200500420 PMID: 16358358

2003

Identification of Alzheimer's Disease-Associated Mitochondrial DNA Mutations by Allele Specific PCR. FASEB JOURNAL.

2002

Profiling of Alzheimer's Brain Mitochondrial Proteins Using Surface Enhanced Laser Desorption/Ionization (SELDI) Mass Spectrometry. FASEB JOURNAL.

2002

Surface Enhanced Laser Desorption/Ionization (SELDI) Mass Spectrometry Profiling of Alzheimer's Brain Mitochondrial Proteins. MOLECULAR BIOLOGY OF THE CELL.

2002

Mitochondrial disorders: a clinician's primer.. Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses. 11:25-9.

PMID: 11901609

2001

The human mitochondrial DNA topoisomerase from camptothecin-resistant CEM/C2 is sensitive to inhibition by camptothecin. FASEB JOURNAL.

2000

Mutation in cytochrome c oxidase subunit III in Alzheimer's Disease. AMERICAN JOURNAL OF HUMAN GENETICS.

1999

Numerous Point Mutations in the Mitochondrially-encoded Cytochrome Oxidase Subunit III Gene Detected by Single Strand Conformational Polymorphism Analysis of Brain Samples From Patients with Alzheimer's Disease. AMERICAN JOURNAL OF HUMAN GENETICS.

1998

Enzymology of Recombinant DNA. Recombinant DNA Principles and Methodologies. Ed. Greene, J. Marcel Dekker.

1998

Gel Electrophoresis and Analysis of DNA and RNA. Recombinant DNA Principles and Methodologies. Ed. Greene, J. Marcel Dekker.

1998

Hybridization Probes. Recombinant DNA Principles and Methodologies. Ed. Greene, J. Marcel Dekker.

1997

Possible Genetic Markers for Rett Syndrome on Mitochondrial DNA: Sequence Analysis of the Large Ribosomal RNA Gene

1997

Elevated levels of the Kearns-Sayre syndrome mitochondrial DNA deletion in temporal cortex of Alzheimer's patients.. Mutation research. 379:253-62.

Full Text via DOI: 10.1016/s0027-5107(97)00158-9 PMID: 9357554

1996

Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool.. LARYNGOSCOPE. 106:777-83.

Full Text via DOI: 10.1097/00005537-199606000-00021 PMID: 8656967

1995

Single Strand Conformational Polymorphism Analysis of mtDNA in Rett Syndrome. Annals of Neurology.

1995

Mammalian mitochondrial DNA topoisomerase I preferentially relaxes supercoils in plasmids containing specific mitochondrial DNA sequences.. Biochimica et biophysica acta. 1264:377-87.

Full Text via DOI: 10.1016/0167-4781(95)00180-8 PMID: 8547327

1995

Mitochondrial DNA deletion analysis: a comparison of PCR quantitative methods.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 207:839-47.

Full Text via DOI: 10.1006/bbrc.1995.1262 PMID: 7864879

1995

Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and m-AMSA.. Archives of biochemistry and biophysics. 324:293-9.

Full Text via DOI: 10.1006/abbi.1995.0042 PMID: 8554321

1995

Rett syndrome studies of natural history and search for a genetic marker.. Neuropediatrics. 26:63-6.

Full Text via DOI: 10.1055/s-2007-979724 PMID: 7566454

1994

Mutation Analysis of Mitochondrial Transfer RNA Genes in Rett Syndrome. Annals of Neurology.

1991

PCR Amplification of Mitochondrial DNA From Organelles In A Single Cell. FASEB JOURNAL.

1981

Isolation of a Topoisomerase with Catenating Activity from Rat Liver Mitochondria. Federal Proceedings.

1980

Evolutionary Relationships Among mtDNAs: Sequence and Hybridization Studies. Federal Proceedings.

1979

Evidence for a DNA Gyrase in Mammalian Mitochondria. Federal Proceedings.

1979

Evidence for a DNA Gyrase in Rat Liver Mitochondria

1979

Search for a DNA gyrase in mammalian mitochondria.. The Journal of biological chemistry. 254:11193-5.

PMID: 227861

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Castora, Frank J.
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