Neelima Chandra
- Research Assistant Professor, Obstetrics and Gynecology
Research Overview
research overview
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As a Post Doc Fellow and later as a research assistant professor at CONRAD in the Department of OB&GYN at EVMS, Norfolk, I have been actively working on detecting and analyzing novel markers of immune cells and epithelium employing immunohistochemical technique in human cervicovaginal mucosa.
My work is mainly focused on " Identification, characterization and development of microbicidal contraceptives" . Have been involved in several clinical and non clinical studies carried out by CONRAD working with different markers of Inflammation in models i.e Mattek ,Explant, Human and animals. Have also been exploring Inflammatory mediators in the placental tissues of pregnancies complicated by Pre-eclampsia.
In past have been working on effect of insecticides and pesticides on male reproduction in vivo and invitro using primary cell culture-Sertoli and germ cells.The effects of pesticides on thyroid physiology was also explored in fish.
Bio
overview
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Done Masters of Science and Ph.D from Banaras Hindu University, Varanasi,India. Pursued Post doctoral research at Industrial Toxicology Research Centre at Lucknow, India. Was awarded several fellowships by different funding agencies to carry out research on the projects submitted.
I have been working in the Department of OB&GYN (CONRAD) at EVMS, Norfolk Virginia, since 2001 as Post. Doc. Fellow and later as Research Assistant Professor carrying out research projects involving several grants under CONRAD program.
List of Publication (as link)
https://www.ncbi.nlm.nih.gov/sites/myncbi/1X195ARbLFAQS/bibliography/51690068/public/?sort=date&direction=ascending.
Projects
projects
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Current Project
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Past Project
- Differential HIV infection and tenofovir activity in pre and postmenopausal women
- Inflammatory mediators in the placental tissues of pregnancies complicated by severe Preclampsia
- Mucin 1 and 4: Potential Biomarkers for Post-Menopausal Changes in the Cervicovaginal Mucosa
- Novel long-acting microbicide and contraceptive intrauterine system
- The Role of Vitamin D in Female Reproductive Tract Immunity
Publications
selected publications
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2022Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 226:225.e1-225.e15.Full Text via DOI: 10.1016/j.ajog.2021.09.018
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2019The Effect of Hormonal Contraception on Cervicovaginal Mucosal End Points Associated with HIV Acquisition. AIDS RESEARCH AND HUMAN RETROVIRUSES. 35:1-12.Full Text via DOI: 10.1089/aid.2018.0298 PMID: 30997816
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2018Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir: Increased Tenofovir Diphosphate in Depot Medroxyprogesterone Acetate Users. AIDS RESEARCH AND HUMAN RETROVIRUSES. 342-342.
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2018Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity. JOURNAL OF CLINICAL INVESTIGATION. 128:4622-4638.Full Text via DOI: 10.1172/JCI120583 PMID: 30222141
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2018Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 78:82-92.Full Text via DOI: 10.1097/QAI.0000000000001648 PMID: 29424790
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2017Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 33:807-819.Full Text via DOI: 10.1089/aid.2016.0320 PMID: 28398069
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2016Epithelial Barrier Alteration and Increased HIV Target Cells Coexist in Inflamed Human Cervices: A Biological Pathway to Enhanced HIV Susceptibility?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 318-318.
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2016Long-acting Intrauterine System Delivers Integrase Inhibitor Throughout the Reproductive Tract of Rabbits and Macaques. AIDS RESEARCH AND HUMAN RETROVIRUSES. 227-227.
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2016The Role of Vitamin D on Genital Mucosal Immunity and Markers of HIV Susceptibility in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 320-320.
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2016Use of Injectable Depot Medroxyprogesterone Acetate (DMPA) Downregulates Vaginal Epithelial Barrier Genes - Similarly to Mucosal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. 46-46.
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2016Comparison of Follicular and Luteal Phase Mucosal Markers of HIV Susceptibility in Healthy Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 32:547-560.Full Text via DOI: 10.1089/aid.2015.0264 PMID: 26750085
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2015Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity. AIDS RESEARCH AND HUMAN RETROVIRUSES. 31:1139-1152.Full Text via DOI: 10.1089/aid.2015.0006 PMID: 26204200
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2015A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. TOXICOLOGY AND APPLIED PHARMACOLOGY. 285:198-206.Full Text via DOI: 10.1016/j.taap.2015.02.017 PMID: 25818602
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2014Effect of Bacterial Vaginosis on Markers of Genital Tract Inflammation and Mucosal Immunity: Mechanisms for Susceptibility to HIV Infection. AIDS RESEARCH AND HUMAN RETROVIRUSES. A30-A30.
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2014Gene Expression Analysis of Human Vaginal Mucosal Response to Pro-inflammatory Stimuli - Identification of Biomarkers of Vaginal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. A239-A239.
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2014Mucosal Susceptibility to HIV-1 and Tenofovir Protection in Explanted Cervicovaginal Tissues from Postmenopausal Compared to Premenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. A264-A265.
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2014COX-2, NF-kappa B, and IL-8 Expression in the Placenta in Severe Preeclampsia. REPRODUCTIVE SCIENCES. 190A-190A.
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2013Toward Early Safety Alert Endpoints: Exploring Biomarkers Suggestive of Microbicide Failure. AIDS RESEARCH AND HUMAN RETROVIRUSES. 29:1475-1486.Full Text via DOI: 10.1089/aid.2012.0345 PMID: 23885658
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2013Depot Medroxyprogesterone Acetate Increases Immune Cell Numbers and Activation Markers in Human Vaginal Mucosal Tissues. AIDS RESEARCH AND HUMAN RETROVIRUSES. 29:592-601.Full Text via DOI: 10.1089/aid.2012.0271 PMID: 23189932
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2013Seminal Plasma Induces Prostaglandin-Endoperoxide Synthase (PTGS) 2 Expression in Immortalized Human Vaginal Cells: Involvement of Semen Prostaglandin E2 in PTGS2 Upregulation. BIOLOGY OF REPRODUCTION. 88.Full Text via DOI: 10.1095/biolreprod.112.101956 PMID: 23153564
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2012A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 56:6272-6283.Full Text via DOI: 10.1128/AAC.01431-12 PMID: 23006751
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2012Impact of depot medroxyprogesterone (DMPA) on human vaginal leukocytes and HIV-1 target cells. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 24-24.
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2012Induction of Cyclooxygenase (COX)-2 in Human Vaginal Epithelial Cells in Response to TLR ligands and TNF-a. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 67:482-490.Full Text via DOI: 10.1111/j.1600-0897.2011.01099.x PMID: 22235849
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2008Six-Day Randomized Safety Trial of Intravaginal Lime Juice. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 49:243-250.
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2007Biomarkers of leukocyte traffic and activation in the vaginal mucosa. BIOMARKERS. 12:608-622.Full Text via DOI: 10.1080/13547500701600670 PMID: 17852080
Contact
preferred title
- Research Assistant Professor
full name
- Neelima Chandra, Ph.D
Other
recognition and awards
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1985-1987**- Junior Research Fellow, at Center for Advanced Study in Zoology, Varanasi, INDIA.
1987-1991* - Senior Research Fellow, at Center for advanced Study in Zoology, Varanasi, INDIA.
1992-1996* - Research Associate, at Industrial Toxicology Research Centre, (ITRC), Lucknow, INDIA.
1997-2000* - Senior Research Associate (Pool Officer) at Industrial Toxicology Research Centre,(ITRC), Lucknow, INDIA.
*Awarded by Council of Scientific and Industrial Research (CSIR), New Delhi, Govt. of India.
**Awarded by Ganga Action Plan (DOE) Govt. of India