Musto, Alberto E.
- Principal Investigator, Medical Educator, Director, Pathology and Anatomy
Overview
overview
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Dr. Alberto E. Musto, MD, PhD, FAES, is an Associate Professor of Pathology, Anatomy and Neurology at Eastern Virginia Medical School in Norfolk, Virginia. He integrates an interdisciplinary approach in medical education and mentorship in neuroscience research, specifically in the field of neuroinflammation. Dr. Musto's primary scientific goal is to identify a potential biomarker and preventive therapies for epilepsy, glioblastoma multiforme, and Alzheimer's disease. Currently, Dr. Musto' s educational interest is to integrate the principles of translational research in medical education through mentorship and improve creative thinking, problem solving, and effective communication for future medical decisions.
Dr. Musto has published in major journals in the field of neuroscience and epilepsy and is a frequent member of National Institute of Health grant review study sections. He has patents in neuroprotection and neuroinflammation and has been invited to speak at national and international scientific meetings.
Prior to join EVMS, Dr. Musto was an Assistant Professor in the Department of Neurosurgery at Louisiana State University Health Science Center (LSUHSC), School of Medicine, New Orleans, LA (2007-2015), where he was actively involved in graduate medical education, neuroscience research, and mentoring underrepresented undergraduate students.
His scholarly activities have been funded, as a principal investigator, mainly by National Institute of Health (NIH), Board of Regents (LSU), EVMS Research Office, National Science Foundation, and Commonwealth Research Board of Virginia.
Dr. Musto was born in Argentina and received his MD degree from the Universidad de Buenos Aires, School of Medicine. He obtained board certifications in both neurology and radiology and in addition, he pursued post-graduate studies in medical education and management in health systems. He practiced medicine for more than a decade and has been actively involved in teaching activities for medical students and residents for more than three decades. He served the Argentinian community promoting health education for underserved population. Dr. Musto obtained his Ph.D. degree in neurobiology from the Universidad de Buenos Aires and relocated to the US where he completed a 4 year postdoctoral fellowship in neuroprotection at LSUHSC, New Orleans, LA.
Dr. Musto is a Fellow of the American Epilepsy Society (FAES) - a lifetime professional honor in recognition of his accomplishments and dedication to excellence in epilepsy.
Publications
selected publications
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2021Brain injuries can set up an epileptogenic neuronal network. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 351-366.Full Text via DOI: 10.1016/j.neubiorev.2021.08.003 PMID: 34384843
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2021Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. SCIENTIFIC REPORTS. 11.Full Text via DOI: 10.1038/s41598-021-96760-3 PMID: 34446808
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2020Cutis verticis gyrata: Two cases associated with drug-resistant epilepsy. CLINICAL CASE REPORTS.Full Text via DOI: 10.1002/ccr3.2814
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2020In-Vivo Preclinical Model of Glioblastoma Multiforme Induced Seizures. American Epilepsy Society, Washington, DC.
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2020Mentorship in translational neurosciences research. A personalized educational approach. 2020 Virginia Regional Health Science Education Symposium. Virginia Commonwealth University, Richmond, VA.
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2020Targeting CD40L-CD40 in Epilepsy. European Association of Neurology. Virtual Congress, Paris, France.
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2019Addressing Cultural Barriers to Diagnosis and Treatment of Epilepsy in Hispanic Communities. JAMA NEUROLOGY. 137-137.Full Text via DOI: 10.1001/jamaneurol.2018.3919 PMID: 30534937
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2019Modulation of epileptogenesis by CD40 activation. EVMS Research Day, Norfolk, VA.
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2019The role of CD40-CD40L in experimental epileptogenesis. merican Epilepsy Society, Baltimore, MD.
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2019Translational Neuroscience in Medical Education, Educational program to Enhance Diversity and Integrate Scientific Research into medical curricula. Harvard Macy Institute, Harvard Medical School, Boston, MA.
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2019Utilización de videos educativos para el aprendizaje del score de Racine en modelos de kindling. Congreso de la Sociedad Argentina de Neurologia, Mar del Plata.
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2019Poster Presentations Abstracts, 23rd Annual Meeting of the International Association of Medical Science Educators, Roanoke, VA, USA, June 8–11, 2019. Medical Science Educator. 29:19-68.Full Text via DOI: 10.1007/s40670-019-00869-0
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2018The role of inflammation in the development of epilepsy. JOURNAL OF NEUROINFLAMMATION.Full Text via DOI: 10.1186/s12974-018-1192-7 PMID: 29764485
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2018Impaired Attentional Set- Shifting Performance after Exposure to 5 cGy of 600 MeV/n Si-28 Particles. RADIATION RESEARCH. 189:273-282.Full Text via DOI: 10.1667/RR14627.1 PMID: 29309264
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2018CD40 deficiency limits seizure severity. America Epilepsy Society, New Orleans, LA.
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2018CD40 mediates seizure severity. 2018 Keystone Symposia. New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet?.
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2018Intranasal Therapy to Stop Status Epilepticus in Prehospital Settings. DRUGS IN R&D. 7-17.Full Text via DOI: 10.1007/s40268-017-0219-3 PMID: 29177587
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2017Comprehensive approach of Medical Spanish curriculum in medical education. IAMSE Burlington, VT.
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2017Exposure to HZE radiation induces seizure susceptibility in a rodent model for human space exploration. NASA Human Research Program Investigators' Workshop. Galveston, TX.
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2017Preventing neuronal network dysfunction following brain injuries. 3rd International Conference on Epilepsy and Treatment. Brussels, Belgium.
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2017Seizure susceptibility in a rodent model for human space exploration. American Epilepsy Society, Washington, DC.
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2016Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism. SCIENTIFIC REPORTS. 6.Full Text via DOI: 10.1038/srep30298 PMID: 27444269
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2016Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism (vol 6, 30298, 2016). SCIENTIFIC REPORTS.Full Text via DOI: 10.1038/srep32253 PMID: 27586961
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2016Identifying potential therapeutic targets for disruption of neuronal networks in epileptogenesis combining systematic review and meta-analysis. American Epilepsy Society, Houston, TX.
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2016Systematic review and analysis for therapeutical intervention in epileptogenesis. EVMS Research Day, Norfolk, VA.
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2016Therapeutic approaches for neuronal network disruption in epileptogenesis. 2nd International Conference on Epilepsy and Treatment, Rome, Italy.
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2015Blood vascular changes associated with chronic active multiple sclerosis plaques: detection by anti-human vascular endothelia-specific monoclonal antibodies. Journal of Pharmaceutical Sciences and Pharmacology.
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2015Disrupted neuronal network activities in glioblastoma multiforme. 28th Annual Meeting of the American Society of Pediatric Hematology/Oncology. Phoenix, AZ.
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2015Hippocampal Neuro-Networks and Dendritic Spine Perturbations in Epileptogenesis Are Attenuated by Neuroprotectin D1. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0116543 PMID: 25617763
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2015miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis. CELL DEATH AND DIFFERENTIATION. 22:1047-1057.Full Text via DOI: 10.1038/cdd.2014.198 PMID: 25476774
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2014Antitumor efficacy of a novel anthracycline derivative aldoxorubicin in an orthotipic mouse model of glioblastoma. AACR Annual Meeting, San Diego, CA.
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2014
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2014Therapeutic Efficacy of Aldoxorubicin in an Intracranial Xenograft Mouse Model of Human Glioblastoma. NEOPLASIA. 16:874-882.Full Text via DOI: 10.1016/j.neo.2014.08.015 PMID: 25379024
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2014Therapeutic efficacy of a novel anthracycline derivative aldoxorubicin in an orthotopic xenograft model of human glioblastoma. LCRC meeting, New Orleans, LA.
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2013Neuroprotectin D1 Attenuates aberrant neuronal networks in epileptogenesis. 5th International Conference on Phospholipase A2 Mediated Signaling in Translational Medicine, New Orleans, LA.
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2013Platelet activating factor antagonism attenuates epileptogenesis. 5th International Conference on Phospholipase A2 Mediated Signaling in Translational Medicine, New Orleans, LA.
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2013Preclinical evaluation of the novel anthracycline derivative aldoxorubicin for human glioblastoma chemotherapy. ESMO, Amsterdam, Netherlands.
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2012All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons. DIFFERENTIATION. 83:233-241.Full Text via DOI: 10.1016/j.diff.2012.03.001 PMID: 22466603
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2012Combined process automation for large-scale EEG analysis. COMPUTERS IN BIOLOGY AND MEDICINE. 42:129-134.Full Text via DOI: 10.1016/j.compbiomed.2011.10.017 PMID: 22136696
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2012Culicchia. Lyn as a potential target for gliomas related with epilepsy. American Epilepsy Society, San Diego, CA.
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2012Generation of GABAergic neurons from encapsulated mouse ES cells. FASEB JOURNAL.
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2012Gliomas and seizures. MEDICAL HYPOTHESES. 79:622-626.Full Text via DOI: 10.1016/j.mehy.2012.07.037 PMID: 22959996
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2012Neuroprotectin D1 attenuates epileptogenesis. American Academy of Neurology, New Orleans, LA.
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2012Neuroprotectin D1 attenuates epileptogenesis. Society for Neuroscience, New Orleans, LA.
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2012Neuroscience translational research program for underrepresented minority students in Louisiana. Society for Neuroscience, New Orleans, LA.
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2011Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity. MOLECULAR NEUROBIOLOGY. 44:216-222.Full Text via DOI: 10.1007/s12035-011-8200-6 PMID: 21918832
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2011Hippocampal hyper excitability and interneuronal-parvalbumin modifications as consequences of status epilepticus. Travel Award for Annual National Student Research Forum, Galveston, TX.
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2011Hippocampal microseizures and neuronal dysfunction as a target for anti-epileptogenesis strategies. Southeast Regional IDEA-NIH New Orleans, LA.
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2011Hippocampal microseizures in epileptogenesis. American Epilepsy Society, San Antonio, TX.
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2011Neuroinflammation triggers modifications in the neuronal network related with hipppocampal hyperexcitabiltiy and seizure susceptibility. Society for Neuroscience, Washington, DC.
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2011Neuroprotectin D1 attenuates epileptic hyperexcitability modulating DG-CA3 circuitry associated with interneuron survival. Southeast Regional IDEA-NIH New Orleans, LA.
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2011Neuroprotectin D1 induces interneuronal-parvalbumin plasticity as a compensatory mechanism in epilepsy. outheast Regional IDEA-NIH New Orleans, LA.
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2011Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy. EPILEPSIA. 52:551-561.Full Text via DOI: 10.1111/j.1528-1167.2010.02920.x PMID: 21204830
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2011The omega-3 fatty acid-derived mediator neuroprotectin D1 (NPD1) limits dentate gyrus hyperexcitablity and seizure susceptibility. American Epilepsy Society, Baltimore, Md.
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2011The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. EPILEPSIA. 52:1601-1608.Full Text via DOI: 10.1111/j.1528-1167.2011.03081.x PMID: 21569016
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2010Epileptiform activities as early markers for epileptogenesis. NIH, NCRR Third Bienal National IDeA Symposium of Biomedical Research Excellence (NISBRE). Bethesda, MD.
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2010Hippocampal epileptiform activity is counteracted by the novel mediator Neuroprotectin D1. Louisiana NCRR/IDeA 2010 Biomedical Research Symposium. Baton Rouge, LA.
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2010Neuroprotectin D1 (NPD1) induces hippocampal neuroprotection in experimental epileptogenesis. Louisiana NCRR/IDeA 2010 Biomedical Research Symposium. Baton Rouge, LA.
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2010Neuroprotectin D1-mediated hippocampal interneuronal protection in seizure-induced damage. NIH, NCRR Third Bienal National IDeA Symposium of Biomedical Research Excellence (NISBRE). Bethesda, MD.
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2010Platelet activating factor receptor antagonism during epileptogenesis. Louisiana NCRR/IDeA 2010 Biomedical Research Symposium. Baton Rouge, LA.
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2010Targeting neuroinflammation in epilepsy: PAF antagonism reduces seizure susceptibility and limits somatostatin cell loss. NIH, NCRR Third Bienal National IDeA Symposium of Biomedical Research Excellence (NISBRE). Bethesda, MD.
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2009Epileptiform activity in early epileptogenesis. Society for Neuroscience, Chicago, IL.
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2009Hippocampal electrical activity during early epileptogenesis. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Impairment of hippocampal oscillatory activity in early epileptogenesis. Southeast NIH IDeA Regional. Charleston, SC.
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2009In vivo microdialysis: a method to study molecular events in epilepsy. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Inflammatory process in experimental epilepsy. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Inflammatory responses in the habenular nuclei in experimental epilepsy. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Inositol lipid signaling in synaptic activity, neuronal plasticity and epileptogenesis. Encyclopedia of Basic Research in Epilepsy. Ed. Schwartzkroin, P.
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2009LAU-0901, a novel PAF antagonist receptor, limits seizure-induced damage. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Neuronal degeneration in experimental epilepsy. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Neuroproctectin D1 modify hippocampal morphology and EEG during epileptogenesis. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Neuroprotectin D1 (NPD1) induces hippocampal neuroprotection in experimental epilepsy. Society for Neuroscience, Chicago, IL.
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2009Neuroprotectin D1 (NPD1) induces hippocampal neuroprotection in experimental epilepsy. XXI Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2009Platelet activating factor in experimental epilepsy. American Epilepsy Society, Washington, DC.
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2009The omega-3 fatty acid derived mediator neuroprotectin D1 (NPD1) downregulates epiletogenesis. American Epilepsy Society, Washington, DC.
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2009Different phases of afterdischarge during rapid kindling procedure in mice.. Epilepsy research. 85:199-205.Full Text via DOI: 10.1016/j.eplepsyres.2009.02.020 PMID: 19375287
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2008Hippocampal epileptiform activity in early epileptogenesis using a kindling model. American Epilepsy Society, Seattle, WA.
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2008Hippocampal oscillations during kindling epileptogenesis in mice. Society for Neuroscience, Washington, DC.
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2008Hippocampal spontaneous epileptiform activity and evoked hyperexcitability in early epileptogenesis using kindling model. XX Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2008Local field potential form hippocampus during epileptogenesis in C57bl/6 mice using silicon probe. XX Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2008Neuroprotectin D1 (NPD1) limits kindling epileptogenesis in mice. Society for Neuroscience, Washington, DC.
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2008Neuroprotectin D1 (NPD1) prevents generalized seizures during kindling.. American Epilepsy Society, Seattle, WA.
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2008Neurorpotectin (NPD1) limits hippocampal afterdischarges during rapid kindling in mice. XX Annual LSUHSC Neuroscience Center of Excellence Retreat, New Orleans, LA.
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2007Hippocampal astrogliosis and neocortical damage after epileptogenesis in adult C57BL/6 mice. LSUHSC-Research Day Meeting, New Orleans, LA.
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2007Inflammatory signaling in epileptogenesis. LSUHSC-Research Day Meeting, New Orleans, LA.
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2007Loss of cortical oligodendrocytes in experimental temporal lobe epilepsy. American Epilepsy Society, Philadelphia, PA.
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2006Generalized seizures are preceded by gamma oscillations during epileptogenesis. American Epilepsy Society, Philadelphia, PA.
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2006c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes.. JOURNAL OF NEUROSCIENCE. 26:8295-304.Full Text via DOI: 10.1523/jneurosci.1986-05.2006 PMID: 16899724
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2005A single systemic injection of a novel PAF-receptor antagonist elicits neuroprotection in brain ischemia-reperfusion. Society for Neuroscience, New Orleans, LA.
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2005Diacylglycerol kinase epsilon modulates kindling epileptogenesis. LSUHSC-Research Day Meeting, New Orleans, LA.
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2005Docosahexaenoic acid activates neuroprotective signaling in kindling epileptogenesis. American Epilepsy Society, Washington, DC.
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2005Genomic profiling of kindling epileptogenesis in diacylglycerol kinase epsilon (DGKe) knockout mice. American Epilepsy Society, Washington, DC.
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2005Inositol lipid signaling modulates hippocampal plasticity in kindling epileptogenesis. The 17th Annual LSUHSC-Neurosciences Center of Excellence Retreat, New Orleans, LA.
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2005Kindling epileptogenesis augment GSK-3beta phosphorylation in neocortex. American Epilepsy Society, Washington, DC.
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2005Kindling epileptogenesis augment GSK-3beta phosphorylation in neocortex. American Epilepsy Society, Washington, DC.
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2005Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 338:77-81.Full Text via DOI: 10.1016/j.bbrc.2005.08.109 PMID: 16137646
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2004Arachidonoyl-Inositol lipid signaling is required for hippocampal excitability in kindling epileptogenesis. Society for Neuroscience, San Diego, CA.
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2004Bazan Genome-wide expression profiling in kindling epileptogenesis. America Epilepsy Society, New Orleans, LA.
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2004Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. America Epilepsy Society, New Orleans, LA.
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2004JNK and JNK-Interaction Protein (JIP) signaling events in kindling epileptogenesis. XVI Annual LSUHSC Neurosciences Center Retreat, New Orleans, LA.
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2004Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. XVI Annual LSUHSC Neurosciences Center Retreat, New Orleans, LA.
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2004PAF antagonism limits the progression of kindling epileptogenesis. America Epilepsy Society, New Orleans, LA.
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2004Synaptic Activity Increases JNK activation responses in kindling epileptogenesis. Society for Neuroscience, San Diego, CA.
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2004The threshold for JNK activation decreases during kindling epileptogenesis. America Epilepsy Society, New Orleans, LA.
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2003Inhibition of leukocyte infiltration in mouse hippocampus and brain cortex after experimental stroke injury by a novel docosahexaenoic acid metabolite. XV Annual LSUHSC Neuroscience Center Retreat, New Orleans, LA.
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2003Reciprocal phosphorylation/dephosphorylation of GSK-3 and Akt in the hippocampus during kindling epileptogenesis. Society for Neuroscience, New Orleans, LA.
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2003Sleep deprivation and EEG analysis. Synaptic signaling in sleep deprivation Project III. D.A.R.P.A.; Lecture; Mackinac Island, MI.
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2003Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.. The Journal of biological chemistry. 278:43807-17.Full Text via DOI: 10.1074/jbc.m305841200 PMID: 12923200
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2003Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons.. JOURNAL OF NEUROSCIENCE. 23:9687-95.PMID: 14573548
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2002After discharges in rapid Kindling model. Electrophysiological and Biochemical approach. LSU Health Sciences Center, Neuroscience Center of Excellence.
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1999Acute disseminated encephalitis. Congreso Argentino de Neurologia, San Juan, Argentina.
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1996Postnatal development of the vibrissae. Structure and innervation. Congreso Argentino de Ciencias Morfológicas,San Luis, Argentina.
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1994EEG sleep patterns and pineal gland. Congreso Argentino de Neurología, Cordoba, Argentina.
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1993The role of the trigeminal system of the adult rat in the kainic convulsive crisis. Congreso Argentino de Neurología, Buenos Aires, Argentina.
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1992New anthropometric parameter of the cranial bone. Congreso Argentino de Radiología y Terapia Radiante, Buenos Aires, Argentina.
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1991Applied anatomy and bio-structural basis of the fornix. Semana de Congresos del Sistema Nervioso, Mar del Plata, Argentina.
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1991ncus hippocampic, topometry and his application in neuroscience. Semana de Congresos del Sistema Nervioso, Mar del Plata, Argentina.
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1991Production of methylguanidine from creatinine via creatol by active oxygen species: analyses of the catabolism in vitro.. Nephron. 58:42-6.Full Text via DOI: 10.1159/000186376 PMID: 1649975
Research
research overview
- His primary research interest is to understand the immune-inflammatory process in the neural tissue following a brain injury that contribute to aberrant neuronal networks formations which mediate the development of epilepsy and cognitive impairments. Dr. Musto, with his collaborators at EVMS and using in vitro and in vivo experimental models of epilepsy, radiation exposure and brain tumors, investigates: a) single neuron and neuronal circuitry activities from hippocampus using silicon probes, multimcroelectrode arrays, and microsensors for glutamate and glucose; b) biology of synapses using histological and biochemical techniques; and c) role of the chemokines and cytokines molecules in the brain. These approaches will contribute to better understanding of the physiopathology of epileptogenesis, to identify a biomarker to predict onset of epilepsy and to determine a novel therapeutic target to prevent recurrent seizures.
projects
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Current Project
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Past Project
- Hyundai Clinical Award-Hope on Wheels program, Children's Hospital of New Orleans
- Inflammatory signaling in epileptogenesis; NIH, National Center for Research Resources 5P20RR016816-10 (PI NGB)
- Platelet activating factor receptor mediate glioblastoma multiforme invasion. Center of Biomedical Research Excellence NIH. Mentoring Neuroscience in LA. A Biomedical Program to Enhance Neuroscience Grant # 5P30GM103340-03 (PI: NGB)
- Research Experiences for Underrepresented Minority Undergraduates in Basic and Genetic Research at Louisiana State University Health Sciences Center (LSUHSC). National Sciences Foundation (NSF).
- Scoliosis surgery planning through cadaveric ligament-skeletal tissue mapping and loading studies, multi-surface segmentation, and finite element simulation of the spine. Collaborative effort between Old Dominion University
- Supervised Undergraduate Research Experiences (SURE). EPSCoR-Louisiana State University, Board of Regents.
Contact
preferred title
- Principal Investigator, Medical Educator, Director
full name
- Alberto E. Musto, MD, PhD
visualizations
research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- Computer Science
- Developmental Biology
- Engineering
- Immunology
- Life Sciences & Biomedicine - Other Topics
- Mathematical & Computational Biology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Radiology, Nuclear Medicine & Medical Imaging
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Urology & Nephrology