Doncel, Gustavo F.

Gustavo F. Doncel
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2022

Ex Vivo HIV Infection Model of Cervico-Vaginal and Rectal Tissue. Methods in Molecular Biology. 157-172.
Full Text via DOI: 10.1007/978-1-0716-1871-4_12
2022

Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 89:87-97.
Full Text via DOI: 10.1097/qai.0000000000002820
2022

Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 226:225.e1-225.e15.
Full Text via DOI: 10.1016/j.ajog.2021.09.018
2021

Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung Cells. PHARMACEUTICALS. 14.
Full Text via DOI: 10.3390/ph14100980 PMID: 34681204
2021

Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomized Controlled Trial. ECLINICALMEDICINE. 36.
Full Text via DOI: 10.1016/j.eclinm.2021.100893 PMID: 34041459
2021

Adaptation and validation of simple tools to screen and monitor for oral PrEP adherence. PLOS ONE. 16.
Full Text via DOI: 10.1371/journal.pone.0251823 PMID: 34043657
2021

Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice. VIRUSES-BASEL. 13.
Full Text via DOI: 10.3390/v13010086 PMID: 33435520
2021

HIV Incidence Among Pregnant and Nonpregnant Women in the FACTS-001 Trial: Implications for HIV Prevention, Especially PrEP Use. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 88:376-383.
Full Text via DOI: 10.1097/qai.0000000000002785
2020

Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis. NATURE COMMUNICATIONS. 11.
Full Text via DOI: 10.1038/s41467-020-19880-w PMID: 33262350
2020

Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women. NUTRIENTS. 12.
Full Text via DOI: 10.3390/nu12103176 PMID: 33080839
2020

Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age.. PLOS ONE. e0224359.
Full Text via DOI: 10.1371/journal.pone.0224359 PMID: 31914129
2020

Concomitant Imbalances of Systemic and Mucosal Immunity Increase HIV Acquisition Risk.. Journal of acquired immune deficiency syndromes (1999). 85-91.
Full Text via DOI: 10.1097/QAI.0000000000002299 PMID: 31985699
2020

Pharmacokinetics of a weekly transdermal delivery system of tenofovir alafenamide in hairless rats.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 582:119342.
Full Text via DOI: 10.1016/j.ijpharm.2020.119342 PMID: 32315746
2019

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings. PLOS ONE. 14.
Full Text via DOI: 10.1371/journal.pone.0217229 PMID: 31107913
2019

The Effect of Hormonal Contraception on Cervicovaginal Mucosal End Points Associated with HIV Acquisition. AIDS RESEARCH AND HUMAN RETROVIRUSES. 35:1-12.
Full Text via DOI: 10.1089/aid.2018.0298 PMID: 30997816
2019

End-user preference for and choice of four vaginally delivered HIV prevention methods among young women in South Africa and Zimbabwe: the Quatro Clinical Crossover Study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 22.
Full Text via DOI: 10.1002/jia2.25283 PMID: 31069957
2019

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV. PHARMACEUTICS. 11.
Full Text via DOI: 10.3390/pharmaceutics11040173 PMID: 30970630
2019

A phase I randomized safety study of a single-size silicone rubber diaphragm used with or without a lactic-acid-containing diaphragm gel. CONTRACEPTION. 100:430-437.
Full Text via DOI: 10.1016/j.contraception.2019.06.004 PMID: 31442441
2019

Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir in Healthy Women: Increased Tenofovir Diphosphate in Injectable Depot Medroxyprogesterone Acetate Users. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 80:79-88.
Full Text via DOI: 10.1097/QAI.0000000000001864 PMID: 30212395
2019

Efficacy is Not Everything: Eliciting Women's Preferences for a Vaginal HIV Prevention Product Using a Discrete-Choice Experiment. AIDS AND BEHAVIOR.
Full Text via DOI: 10.1007/s10461-019-02715-1 PMID: 31696371
2019

Integrated provision of topical pre-exposure prophylaxis in routine family planning services in South Africa: a non-inferiority randomized controlled trial. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 22.
Full Text via DOI: 10.1002/jia2.25381 PMID: 31507088
2019

Topical Inserts: A Versatile Delivery Form for HIV Prevention. PHARMACEUTICS.
Full Text via DOI: 10.3390/pharmaceutics11080374 PMID: 31374941
2018

Seminal exosomes and HIV-1 transmission. ANDROLOGIA.
Full Text via DOI: 10.1111/and.13220 PMID: 30569645
2018

Tenofovir 1% vaginal gel for prevention of HIV-1 infection in women in South Africa (FACTS-001): a phase 3, randomised, double-blind, placebo-controlled trial. LANCET INFECTIOUS DISEASES. 18:1241-1250.
2018

A Longitudinal Assessment of Cervical Inflammation and Immunity Associated with HIV-1 Infection, Hormonal Contraception, and Pregnancy. AIDS RESEARCH AND HUMAN RETROVIRUSES. 34:889-899.
Full Text via DOI: 10.1089/aid.2018.0022 PMID: 30047279
2018

Anti-HIV Activity and Drug Concentrations in Tenofovir-based Products: Intravaginal Ring Versus Oral Tablet. AIDS RESEARCH AND HUMAN RETROVIRUSES. 343-343.
2018

Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir: Increased Tenofovir Diphosphate in Depot Medroxyprogesterone Acetate Users. AIDS RESEARCH AND HUMAN RETROVIRUSES. 342-342.
2018

Estrogen, Progesterone and Sex-hormone Binding Globulin in Association With Innate Immunity Correlates of HIV Risk and Protection. AIDS RESEARCH AND HUMAN RETROVIRUSES. 217-217.
2018

HIV Prevention in Healthy Women: Safety and Pharmacokinetics of a Potential New Tenofovir Alafenamide Fumarate (TAF)-based Oral PrEP Regimen. AIDS RESEARCH AND HUMAN RETROVIRUSES. 56-56.
2018

Testing Objective Markers of Placebo Vaginal Product Adherence in the Field. AIDS RESEARCH AND HUMAN RETROVIRUSES. 26-26.
2018

Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity. JOURNAL OF CLINICAL INVESTIGATION. 128:4622-4638.
Full Text via DOI: 10.1172/JCI120583 PMID: 30222141
2018

Using Photovoice to Understand the Experience and Realities of Female Sex Workers in the Context of HIV Self-testing in Blantyre, Malawi. AIDS RESEARCH AND HUMAN RETROVIRUSES. 158-158.
2018

Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using Placebo, Tenofovir and Tenofovir/Levonorgestrel Vaginal Rings. AIDS RESEARCH AND HUMAN RETROVIRUSES. 295-295.
2018

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women. PLOS ONE. 13.
Full Text via DOI: 10.1371/journal.pone.0199778 PMID: 29953547
2018

Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant techniques. PLOS ONE. 13.
Full Text via DOI: 10.1371/journal.pone.0197906 PMID: 29799875
2018

Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 78:82-92.
Full Text via DOI: 10.1097/QAI.0000000000001648 PMID: 29424790
2018

Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies. CLINICAL AND TRANSLATIONAL MEDICINE. 7.
Full Text via DOI: 10.1186/s40169-018-0213-6 PMID: 30402770
2018

Tenofovir 1% vaginal gel for prevention of HIV-1 infection in women in South Africa (FACTS-001): a phase 3, randomised, double-blind, placebo-controlled trial. LANCET INFECTIOUS DISEASES. 18:1241-1250.
Full Text via DOI: 10.1016/S1473-3099(18)30428-6 PMID: 30507409
2017

A phase I randomized postcoital testing and safety study of the Caya diaphragm used with 3% Nonoxynol-9 gel, ContraGel or no gel. CONTRACEPTION. 96:124-130.
Full Text via DOI: 10.1016/j.contraception.2017.05.016 PMID: 28606382
2017

Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 33:807-819.
Full Text via DOI: 10.1089/aid.2016.0320 PMID: 28398069
2017

Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 27:1934-1937.
Full Text via DOI: 10.1016/j.bmc1.2017.03.031
2017

Analytical Advances in the Ex Vivo Challenge Efficacy Assay. AIDS RESEARCH AND HUMAN RETROVIRUSES. 33:395-403.
Full Text via DOI: 10.1089/aid.2016.0073 PMID: 27841671
2017

Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 27:1934-1937.
Full Text via DOI: 10.1016/j.bmcl.2017.03.031 PMID: 28351588
2016

Assessment of the vaginal residence time of biomarkers of semen exposure. CONTRACEPTION. 94:512-520.
Full Text via DOI: 10.1016/j.contraception.2016.05.012 PMID: 27259675
2016

Can Infrared Spectroscopy (IR) Coupled with Chemometrics Be Used for Objective Measure of Adherence to Microbicide Products?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 94-94.
2016

Clinical Assessment of New Objective Measures of Adherence for Four Placebo Vaginal Dosage Platforms. AIDS RESEARCH AND HUMAN RETROVIRUSES. 95-95.
2016

Clinical Performance, Acceptability, and Optimization of Fast-dissolve Vaginal Inserts Designed for HIV-prevention: Results from Two Clinical Studies. AIDS RESEARCH AND HUMAN RETROVIRUSES. 53-53.
2016

Correlation of Residual Microbicide Levels with Objective Biomarker Analysis to Determine Adherence in a Large Phase III HIV Prevention Trial. AIDS RESEARCH AND HUMAN RETROVIRUSES. 387-387.
2016

Development and Proof-of-Concept Clinical Evaluation of a Freeze-dried Topical Microbicide Insert for On-demand HIV Prevention. AIDS RESEARCH AND HUMAN RETROVIRUSES. 69-69.
2016

Epithelial Barrier Alteration and Increased HIV Target Cells Coexist in Inflamed Human Cervices: A Biological Pathway to Enhanced HIV Susceptibility?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 318-318.
2016

Long-acting Intrauterine System Delivers Integrase Inhibitor Throughout the Reproductive Tract of Rabbits and Macaques. AIDS RESEARCH AND HUMAN RETROVIRUSES. 227-227.
2016

Pharmacokinetics/Pharmacodynamics of Tenofovir and Tenofovir Plus Levonorgestrel Vaginal Rings in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 389-389.
2016

The Role of Vitamin D on Genital Mucosal Immunity and Markers of HIV Susceptibility in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 320-320.
2016

Time of Addition Studies of Elvitegravir/TFV Prodrug Combinations Demonstrate Extended Window of Prophylactic Activity in Cell and Tissue Models. AIDS RESEARCH AND HUMAN RETROVIRUSES. 232-232.
2016

Use of Injectable Depot Medroxyprogesterone Acetate (DMPA) Downregulates Vaginal Epithelial Barrier Genes - Similarly to Mucosal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. 46-46.
2016

Comparison of Follicular and Luteal Phase Mucosal Markers of HIV Susceptibility in Healthy Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 32:547-560.
Full Text via DOI: 10.1089/aid.2015.0264 PMID: 26750085
2016

Biomarkers of Cervical Inflammation and Immunity Associated with Cervical Shedding of HIV-1. AIDS RESEARCH AND HUMAN RETROVIRUSES. 32:443-451.
Full Text via DOI: 10.1089/aid.2015.0088 PMID: 26650885
2016

Blocking CXCL9 Decreases HIV-1 Replication and Enhances the Activity of Prophylactic Antiretrovirals in Human Cervical Tissues. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 71:474-482.
Full Text via DOI: 10.1097/QAI.0000000000000891 PMID: 26545124
2016

Multipurpose Prevention Approaches with Antiretroviral-Based Formulations. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 60:1141-1144.
Full Text via DOI: 10.1128/AAC.02468-15 PMID: 26596943
2015

Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity. AIDS RESEARCH AND HUMAN RETROVIRUSES. 31:1139-1152.
Full Text via DOI: 10.1089/aid.2015.0006 PMID: 26204200
2015

Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical Tissues. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0131919 PMID: 26121689
2015

A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. TOXICOLOGY AND APPLIED PHARMACOLOGY. 285:198-206.
Full Text via DOI: 10.1016/j.taap.2015.02.017 PMID: 25818602
2015

Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0128557 PMID: 26052926
2015

Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 5:27-37.
Full Text via DOI: 10.1007/s13346-015-0216-4 PMID: 25787337
2015

Design, Synthesis, Antiviral Activity, and Pre-Formulation Development of Poly-L-Arginine-Fatty Acyl Derivatives of Nucleoside Reverse Transcriptase Inhibitors. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 34:1-15.
Full Text via DOI: 10.1080/15257770.2014.945649 PMID: 25513860
2015

The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception. MBIO. 6.
Full Text via DOI: 10.1128/mBio.00221-15 PMID: 26330510
2014

Development of a Composite Measure of Product Adherence, Protocol Compliance, and Semen Exposure Using DNA and Protein Biomarkers for Topical HIV Prevention Studies. PLOS ONE. 9.
Full Text via DOI: 10.1371/journal.pone.0114368 PMID: 25489736
2014

Comparison of Visual and Ultraviolet Light Inspection Versus DNA/Protein Biomarkers to Assess Product Adherence With Vaginal Microbicide Applicators. SEXUALLY TRANSMITTED DISEASES. 41:739-746.
Full Text via DOI: 10.1097/OLQ.0000000000000209 PMID: 25581811
2014

Assessment of the Vaginal Residence Time of Biomarkers of Semen Exposure. AIDS RESEARCH AND HUMAN RETROVIRUSES. A172-A172.
2014

Effect of Bacterial Vaginosis on Markers of Genital Tract Inflammation and Mucosal Immunity: Mechanisms for Susceptibility to HIV Infection. AIDS RESEARCH AND HUMAN RETROVIRUSES. A30-A30.
2014

GLOBAL ENDOMETRIAL GENE EXPRESSION WITH CONTINUOUS EXPOSURE TO LEVONORGESTREL (LNG) VIA AN INTRAUTERINE SYSTEM (IUS).. FERTILITY AND STERILITY. E141-E141.
2014

Gene Expression Analysis of Human Vaginal Mucosal Response to Pro-inflammatory Stimuli - Identification of Biomarkers of Vaginal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. A239-A239.
2014

Humic Acids (HA) Strongly Potentiate Anti-HIV Effects of AZT, Griffithsin, and Cyanovirin. AIDS RESEARCH AND HUMAN RETROVIRUSES. A204-A204.
2014

Mucosal Susceptibility to HIV-1 and Tenofovir Protection in Explanted Cervicovaginal Tissues from Postmenopausal Compared to Premenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. A264-A265.
2014

Multicompartmental Pharmacokinetics of Tenofovir 1% Gel Using the BAT 24 Regimen Versus Daily and Single Pericoital Dosing. AIDS RESEARCH AND HUMAN RETROVIRUSES. A37-A37.
2014

Population Pharmacokinetic Model of Vaginal Tenofovir 1% Gel in the Cervicovaginal Fluid. AIDS RESEARCH AND HUMAN RETROVIRUSES. A38-A38.
2014

Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides. MUCOSAL IMMUNOLOGY. 7:1165-1174.
Full Text via DOI: 10.1038/mi.2014.3 PMID: 24496317
2014

Anti-HIV Activities of Precisely Defined, Semirigid, Carboxylated Alternating Copolymers. JOURNAL OF MEDICINAL CHEMISTRY. 57:6354-6363.
Full Text via DOI: 10.1021/jm401913w PMID: 25026140
2014

Does tenofovir gel or do other microbicide products affect detection of biomarkers of semen exposure in vitro?. CONTRACEPTION. 90:136-141.
Full Text via DOI: 10.1016/j.contraception.2014.03.009 PMID: 24746557
2014

Cervical Inflammation and Immunity Associated With Hormonal Contraception, Pregnancy, and HIV-1 Seroconversion. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 66:109-117.
Full Text via DOI: 10.1097/QAI.0000000000000103 PMID: 24413042
2014

Effects of Hormonal Contraception on Antiretroviral Drug Metabolism, Pharmacokinetics and Pharmacodynamics. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 523-530.
Full Text via DOI: 10.1111/aji.12210 PMID: 24521428
2014

Role of Semen in Modulating the Female Genital Tract Microenvironment-Implications for HIV Transmission. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 564-574.
Full Text via DOI: 10.1111/aji.12231 PMID: 24702729
2014

Pharmacokinetic and Safety Analyses of Tenofovir and TenofovirEmtricitabine Vaginal Tablets in Pigtailed Macaques. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 58:2665-2674.
Full Text via DOI: 10.1128/AAC.02336-13 PMID: 24566178
2014

COX-2, NF-kappa B, and IL-8 Expression in the Placenta in Severe Preeclampsia. REPRODUCTIVE SCIENCES. 190A-190A.
2014

Effect of lubricants and a vaginal spermicide gel on the detection of prostate specific antigen, a biomarker of semen exposure, using a quantitative (Abbott ARCHITECT) assay. CONTRACEPTION. 89:134-138.
Full Text via DOI: 10.1016/j.contraception.2013.09.016 PMID: 24314911
2014

Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention.
Full Text via DOI: 10.3390/pharmaceutics6040616 PMID: 25494201
2013

Toward Early Safety Alert Endpoints: Exploring Biomarkers Suggestive of Microbicide Failure. AIDS RESEARCH AND HUMAN RETROVIRUSES. 29:1475-1486.
Full Text via DOI: 10.1089/aid.2012.0345 PMID: 23885658
2013

TSPY4 is a novel sperm-specific biomarker of semen exposure in human cervicovaginal fluids; potential use in HIV prevention and contraception studies. CONTRACEPTION. 88:387-395.
Full Text via DOI: 10.1016/j.contraception.2012.11.022 PMID: 23312930
2013

DOES TENOFOVIR GEL - OR DO OTHER VAGINAL MICROBICIDE PRODUCTS - AFFECT DETECTION OF BIOMARKERS OF SEMEN EXPOSURE?. SEXUALLY TRANSMITTED INFECTIONS. A263-A263.
Full Text via DOI: 10.1136/sextrans-2013-051184.0817
2013

Depot Medroxyprogesterone Acetate Increases Immune Cell Numbers and Activation Markers in Human Vaginal Mucosal Tissues. AIDS RESEARCH AND HUMAN RETROVIRUSES. 29:592-601.
Full Text via DOI: 10.1089/aid.2012.0271 PMID: 23189932
2013

Emtricitabine Prodrugs with Improved Anti-HIV Activity and Cellular Uptake. MOLECULAR PHARMACEUTICS. 10:467-476.
Full Text via DOI: 10.1021/mp300361a PMID: 22917277
2013

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies. INTERNATIONAL JOURNAL OF WOMENS HEALTH. 695-708.
Full Text via DOI: 10.2147/IJWH.S34030 PMID: 24174884
2013

Seminal Plasma Induces Prostaglandin-Endoperoxide Synthase (PTGS) 2 Expression in Immortalized Human Vaginal Cells: Involvement of Semen Prostaglandin E2 in PTGS2 Upregulation. BIOLOGY OF REPRODUCTION. 88.
Full Text via DOI: 10.1095/biolreprod.112.101956 PMID: 23153564
2012

A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 56:6272-6283.
Full Text via DOI: 10.1128/AAC.01431-12 PMID: 23006751
2012

Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota. MBIO. 3.
Full Text via DOI: 10.1128/mBio.00370-12 PMID: 23249810
2012

Association between STI/RTI infections, altered cervical innate immunity and HIV-1 seroconversion among hormonal contraceptive users. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 81-81.
2012

Development of a new intravaginal ring technology for the extended delivery of the microbicide tenofovir with and without the contraceptive levonorgestrel. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 27-27.
2012

Impact of depot medroxyprogesterone (DMPA) on human vaginal leukocytes and HIV-1 target cells. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 24-24.
2012

Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention. INTERNATIONAL JOURNAL OF STD & AIDS. 613-619.
Full Text via DOI: 10.1258/ijsa.2012.011356 PMID: 23033511
2012

Induction of Cyclooxygenase (COX)-2 in Human Vaginal Epithelial Cells in Response to TLR ligands and TNF-a. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 67:482-490.
Full Text via DOI: 10.1111/j.1600-0897.2011.01099.x PMID: 22235849
2012

Synthesis and Biological Evaluation of Fatty Acyl Ester Derivatives of (-)-2 ',3 '-Dideoxy-3 '-thiacytidine. JOURNAL OF MEDICINAL CHEMISTRY. 55:4861-4871.
Full Text via DOI: 10.1021/jm300492q PMID: 22533850
2012

Synthesis and Anti-HIV Activities of Glutamate and Peptide Conjugates of Nucleoside Reverse Transcriptase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY. 55:2672-2687.
Full Text via DOI: 10.1021/jm201551m PMID: 22352809
2012

Synthesis and Anti-HIV Activities of Suramin Conjugates of 3 '-Fluoro-2 ',3 '-dideoxythymidine and 3 '-Azido-2 ',3 '-dideoxythymidine. MEDICINAL CHEMISTRY. 8:193-197.
2012

Superoxide dismutase content in sperm correlates with motility recovery after thawing of cryopreserved human spermatozoa. FERTILITY AND STERILITY. 97:293-298.
Full Text via DOI: 10.1016/j.fertnstert.2011.11.012 PMID: 22154371
2012

Non-Specific Microbicide Product Development: Then and Now. CURRENT HIV RESEARCH. 10:9-18.
Full Text via DOI: 10.2174/157016212799304625 PMID: 22264041
2012

Non-Specific Microbicide Product Development: Then and Now. CURRENT HIV RESEARCH. 10:9-18.
2012

Synthesis and Anti-HIV Activities of Suramin Conjugates of 3 '-Fluoro-2 ',3 '-dideoxythymidine and 3 '-Azido-2 ',3 '-dideoxythymidine. MEDICINAL CHEMISTRY. 8:193-197.
Full Text via DOI: 10.2174/157340612800493737 PMID: 22385137
2012

Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation. FERTILITY AND STERILITY. 97:39-U93.
Full Text via DOI: 10.1016/j.fertnstert.2011.10.012 PMID: 22112647
2011

Bridging the Gap between Preclinical and Clinical Microbicide Trials: Blind Evaluation of Candidate Gels in Murine Models of Efficacy and Safety. PLOS ONE. 6.
Full Text via DOI: 10.1371/journal.pone.0027675 PMID: 22096611
2011

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action. MBIO. 2.
Full Text via DOI: 10.1128/mBio.00168-11 PMID: 22027006
2011

Increased COX-2 Expression in Human Vaginal Epithelial Cells Exposed to Nonoxynol-9, a Vaginal Contraceptive Microbicide that Failed to Protect Women from HIV-1 Infection. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 65:569-577.
Full Text via DOI: 10.1111/j.1600-0897.2010.00964.x PMID: 21241401
2011

Preclinical evaluation of UC781 microbicide vaginal drug delivery. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 1:175-182.
Full Text via DOI: 10.1007/s13346-011-0019-1 PMID: 25788115
2011

Synthesis and biological evaluation of fatty acyl ester derivatives of 2 ',3 '-didehydro-2 ',3 '-dideoxythymidine. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 21:1917-1921.
Full Text via DOI: 10.1016/j.bmcl.2011.02.070 PMID: 21382714
2011

Role of Semen in HIV-1 Transmission: Inhibitor or facilitator?. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 292-301.
Full Text via DOI: 10.1111/j.1600-0897.2010.00931.x PMID: 21087339
2011

Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3 '-fluoro-3 '-deoxythymidine and 3 '-azido-3 '-deoxythymidine. TETRAHEDRON LETTERS. 52:802-805.
Full Text via DOI: 10.1016/j.tetlet.2010.12.038 PMID: 26661937
2011

Innate Immunity and Inflammatory Response to Trichomonas vaginalis and Bacterial Vaginosis: Relationship to HIV Acquisition. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 89-98.
Full Text via DOI: 10.1111/j.1600-0897.2010.00902.x PMID: 20678168
2011

Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.. Infectious diseases in obstetrics and gynecology. 1-10.
Full Text via DOI: 10.1155/2011/429403 PMID: 21836811
2010

Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies. ANTIVIRAL RESEARCH. S47-S54.
Full Text via DOI: 10.1016/j.antiviral.2010.09.005 PMID: 21109068
2010

Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers. ANTIVIRAL RESEARCH. S10-S18.
Full Text via DOI: 10.1016/j.antiviral.2010.09.018 PMID: 21109063
2010

Preventing mucosal HIV transmission with topical microbicides: Challenges and opportunities. ANTIVIRAL RESEARCH. S3-S9.
Full Text via DOI: 10.1016/j.antiviral.2010.09.011 PMID: 21109065
2010

Synthesis, antiviral and contraceptive activities of nucleoside-sodium cellulose sulfate acetate and succinate conjugates. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 20:6993-6997.
Full Text via DOI: 10.1016/j.bmcl.2010.09.133 PMID: 20965725
2010

Synthesis of bis(cycloSaligenyl) pronucleotides containing two nucleosides from bis (methoxymethyl)benzene-1,4-diol. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2010

Synthesis of lipophilic dodecyl bis(cycloSaligenyl) nucleoside monophosphate triesters. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2010

Effect of thawing temperature on the motility recovery of cryopreserved human spermatozoa. FERTILITY AND STERILITY. 93:789-794.
Full Text via DOI: 10.1016/j.fertnstert.2008.10.021 PMID: 19059590
2009

High Cholesterol Content and Decreased Membrane Fluidity in Human Spermatozoa Are Associated With Protein Tyrosine Phosphorylation and Functional Deficiencies. JOURNAL OF ANDROLOGY. 30:552-558.
Full Text via DOI: 10.2164/jandrol.108.006551 PMID: 19269935
2009

Bis(cycloSaligenyl) derivatives of nucleosides: Synthesis and anti-HIV activities. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2009

Synthesis and anti-HIV activity of glutamate-nucleoside conjugates. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2009

Capacitation-associated changes in membrane fluidity in asthenozoospermic human spermatozoa. INTERNATIONAL JOURNAL OF ANDROLOGY. 32:360-375.
Full Text via DOI: 10.1111/j.1365-2605.2008.00874.x PMID: 18399983
2009

Comparing anti-HIV, antibacterial, antifungal, micellar, and cytotoxic properties of tricarboxylato dendritic amphiphiles. BIOORGANIC & MEDICINAL CHEMISTRY. 17:3162-3168.
Full Text via DOI: 10.1016/j.bmc.2009.02.055 PMID: 19307123
2009

Polyanionic Microbicides Modify Toll-Like Receptor-Mediated Cervicovaginal Immune Responses. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 53:1490-1500.
Full Text via DOI: 10.1128/AAC.01152-08 PMID: 19139286
2009

Biomarkers of Cervicovaginal Inflammation for the Assessment of Microbicide Safety. SEXUALLY TRANSMITTED DISEASES. S84-S91.
Full Text via DOI: 10.1097/OLQ.0b013e3181994191 PMID: 19218890
2008

Six-Day Randomized Safety Trial of Intravaginal Lime Juice. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 49:243-250.
2008

MEDI 325-Synthesis and anti-HIV activity of fatty acyl derivatives of Stavudine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2008

MEDI 442-Synthesis of cellulose sulfate-nucleoside conjugates as bifunctional anti-HIV agents. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2008

Synthesis and anti-HIV activities of phosphate triester derivatives of 3 '-fluoro-2 ',3 '-dideoxythymidine and 3 '-azido-2 ',3 '-dideoxythymidine. TETRAHEDRON LETTERS. 49:4905-4907.
Full Text via DOI: 10.1016/j.tetlet.2008.05.149
2008

A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 32:180-185.
Full Text via DOI: 10.1016/j.ijantimicag.2008.03.004 PMID: 18571386
2008

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study. ANALYTICAL CHEMISTRY. 80:4741-4751.
Full Text via DOI: 10.1021/ac702628q PMID: 18484740
2008

Surfactants as microbicidal contraceptives: A calorimetric study of partitioning and translocation in model membrane systems. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH. 47:3554-3561.
Full Text via DOI: 10.1021/ie071105e
2008

As the world grows: contraception in the 21st century. JOURNAL OF CLINICAL INVESTIGATION. 1330-1343.
Full Text via DOI: 10.1172/JCI33873 PMID: 18382745
2008

Preclinical evaluation of lime juice as a topical microbicide candidate. RETROVIROLOGY. 5.
Full Text via DOI: 10.1186/1742-4690-5-3 PMID: 18190686
2007

MEDI 97-Synthesis and evaluation of bis(fatty acyl-glycol)phosphate triester derivatives of 3'-fluoro-2',3'-dideoxythymidine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
2007

Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV. CONTRACEPTION. 407-419.
Full Text via DOI: 10.1016/j.contraception.2007.02.007 PMID: 17519146
2007

Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging. HUMAN REPRODUCTION. 22:743-750.
Full Text via DOI: 10.1093/humrep/del439 PMID: 17110399
2007

Biomarkers of leukocyte traffic and activation in the vaginal mucosa. BIOMARKERS. 12:608-622.
Full Text via DOI: 10.1080/13547500701600670 PMID: 17852080
2006

Decreased protein tyrosine phosphorylation and membrane fluidity in spermatozoa from infertile men with varicocele. MOLECULAR REPRODUCTION AND DEVELOPMENT. 73:1591-1599.
Full Text via DOI: 10.1002/mrd.20611 PMID: 16897700
2006

Amino acid conjugated sophorolipids: A new family of biologically active functionalized glycolipids. BIOCONJUGATE CHEMISTRY. 17:1523-1529.
Full Text via DOI: 10.1021/bc060094n PMID: 17105232
2006

A time-resolved fluorescence diphenylhexatriene (DPH) anisotropy characterization of a series of model lipid constructs for the sperm plasma membrane. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH. 45:6939-6945.
Full Text via DOI: 10.1021/ie058084d
2006

Exploiting common targets in human fertilization and HIV infection: development of novel contraceptive microbicides. HUMAN REPRODUCTION UPDATE. 103-117.
Full Text via DOI: 10.1093/humupd/dmi040 PMID: 16172109
2006

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 50:713-723.
Full Text via DOI: 10.1128/AAC.50.2.713-723.2006 PMID: 16436731
2005

In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS RESEARCH AND HUMAN RETROVIRUSES. 21:845-853.
2005

Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 49:4093-4100.
Full Text via DOI: 10.1128/AAC.49.10.4093-4100.2005 PMID: 16189085
2005

Capacitation-associated changes in spermatozoa from varicocele patients.. FERTILITY AND STERILITY. S77-S77.
2005

Capacitation-associated protein tyrosine phosphorylation and membrane fluidity changes are impaired in the spermatozoa of asthenozoospermic patients. REPRODUCTION. 129:697-705.
Full Text via DOI: 10.1530/rep.1.00584 PMID: 15923385

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Gustavo F. Doncel

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