Tushar A. Shah
Offers student research opportunities
Positions
- Chair, Pediatric Basic Sciences, Pediatrics
Research Overview
research overview
-
Neonatal asphyxia (hypoxic-ischemic encephalopathy, [HIE]) is a significant cause of neonatal mortality and disability. The complement system, the most potent inflammatory cascade in humans, and plays critical roles in neuroinflammation and repair. Our lab is interested in understanding the deleterious and homeostatic roles of the classical complement pathway in neonatal HIE. Using a well-characterized rodent model of neonatal HIE, our lab is elucidating key pathways that may be be instrumental in developing new therapies for this complex disease.
Periventricular leukomalacia (PVL), the most common cause of cerebral palsy in prematurely born infants, is a multifactorial disease resulting in focal necrosis and gliosis of the periventricular white matter. Preterm infants are especially sensitive to Ischemic and inflammatory injuries to the developing brain, resulting in injury to the immature oligodendroglia in the cerebral white matter and subplate neurons immediately below the neocortex. There are currently no therapies for PVL, and the underlying mechanisms are incompletely understood. The focus of this research is to elucidate the mechanisms dictating the development of PVL, and to identify targets and pathways contributing to PVL to guide future pharmacological intervention
Bio
overview
-
Dr. Shah is a physician-scientist with a passion for evidence-based medicine, hypothesis-driven research, and teaching. As an independent investigator, Dr. Shah's lab specializes in complement biology, and has been funded by the NIH, Virginia Catalyst and Commonwealth Health Research Board. His lab focuses on understanding the role of inflammation in neonatal hypoxic-ischemic encephalopathy (HIE) and Periventricular Leukomalacia (PVL), with the goal of developing new therapeutic strategies.
Dr. Shah completed his fellowship in neonatology at Cincinnati Children's Hospital Medical Center and holds a masters degree in public health in epidemiology from Emory University in Atlanta.He holds faculty appointments in the divisions of pediatrics, microbiology and molecular cell biology and is an adjunct faculty member in the Biomedical Sciences Graduate Program at Eastern Virginia Medical School.
In addition to his clinical and research endeavors, Dr. Shah also runs a pathophysiology interest group with pediatric house-staff, leading in-depth discussions about mechanisms of neonatal diseases.
CURRENT POSITION
Assistant Professor of Pediatrics, Microbiology/Molecular Biology
Eastern Virginia Medical School
Attending Neonatologist
Children's Specialty Group
Children's Hospital of the King's Daughters
EDUCATION
1996-2002: Mumbai University - Topiwala National Medical College, Mumbai, India
Bachelor of Medicine and Bachelor of Surgery (M.B.; B.S.), October 2000
2002-2004: Emory University, Rollins School of Public Health, Atlanta, GA, M.P.H., Epidemiology, May 2004
TRAINING
2004-2007 Residency in Pediatrics
Metrohealth Medical Center/Case Western Reserve University
Cleveland, OH
2007-2010 Fellowship in Neonatal-Perinatal Medicine
Cincinnati Children's Hospital Medical Center
Cincinnati, OH
BOARD CERTIFICATIONS
American Board of Pediatrics - Pediatrics
American Board of Pediatrics - Neonatal-Perinatal Medicine
Projects
Publications
selected publications
-
2020Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future.. PEDIATRIC RESEARCH.Full Text via DOI: 10.1038/s41390-020-0859-9 PMID: 32221474
-
2019Elevated midline head positioning of extremely low birth weight infants: effects on cardiopulmonary function and the incidence of periventricular-intraventricular hemorrhage.. JOURNAL OF PERINATOLOGY. 39:54-62.Full Text via DOI: 10.1038/s41372-018-0261-1 PMID: 30348960
-
2017Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy. PEDIATRIC RESEARCH. 81:654-662.Full Text via DOI: 10.1038/pr.2016.271 PMID: 28002390
-
2017Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. PLOS ONE. 12.Full Text via DOI: 10.1371/journal.pone.0173257 PMID: 28278205
-
2017Changes in Cerebral Oxygenation in Preterm Infants With Progressive Posthemorrhagic Ventricular Dilatation.. Pediatric neurology. 73:57-63.Full Text via DOI: 10.1016/j.pediatrneurol.2017.05.012 PMID: 28651978
-
2016Peptide inhibitor of complement C1 modulates acute intravascular hemolysis of mismatched red blood cells in rats. TRANSFUSION. 56:2133-2145.Full Text via DOI: 10.1111/trf.13674 PMID: 27282513
-
2016Eosinophil Quantitated Urine Kinetic A novel assay for assessment of eosinophilic esophagitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 116:435-439.Full Text via DOI: 10.1016/j.anai.2016.02.011 PMID: 27017558
-
2015Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0144723 PMID: 26642048
-
2014Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis. TRANSFUSION. 54:2892-2900.Full Text via DOI: 10.1111/trf.12695 PMID: 24806146
-
2014Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway. JOURNAL OF TRANSLATIONAL MEDICINE. 12.Full Text via DOI: 10.1186/1479-5876-12-181 PMID: 24962100
-
2014Neonatal Complications. Manual of Obstetrics, Eighth Edition. Ed. Evans, Arthur. Lippincott Manual.
-
2013FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.. MOLECULAR AND CELLULAR BIOLOGY. 33:371-86.Full Text via DOI: 10.1128/mcb.00934-12 PMID: 23149934
-
2012Hospital and neurodevelopmental outcomes of extremely low-birth-weight infants with necrotizing enterocolitis and spontaneous intestinal perforation.. JOURNAL OF PERINATOLOGY. 32:552-8.Full Text via DOI: 10.1038/jp.2011.176 PMID: 22157625
-
2011Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation.. JOURNAL OF PERINATOLOGY. 31:635-40.Full Text via DOI: 10.1038/jp.2010.213 PMID: 21311503
-
2010Cardiac and pulmonary function variability in Duchenne/Becker muscular dystrophy: an initial report.. JOURNAL OF CHILD NEUROLOGY. 25:1110-5.Full Text via DOI: 10.1177/0883073810371003 PMID: 20501885
-
2010Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair.. MOLECULAR AND CELLULAR BIOLOGY. 30:5381-93.Full Text via DOI: 10.1128/mcb.00876-10 PMID: 20837707
-
2010Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis.. PEDIATRIC RESEARCH. 68:210-5.Full Text via DOI: 10.1203/pdr.0b013e3181e9c556 PMID: 20703142
-
2008Symptomatic nephrolithiasis in prolonged survivors of Duchenne muscular dystrophy.. Neuromuscular disorders : NMD. 18:561-4.Full Text via DOI: 10.1016/j.nmd.2008.05.001 PMID: 18579382
-
2006Sudden infant death syndrome and reported maternal smoking during pregnancy.. AMERICAN JOURNAL OF PUBLIC HEALTH. 96:1757-9.Full Text via DOI: 10.2105/ajph.2005.073213 PMID: 17008569
Contact
preferred title
- Chair, Pediatric Basic Sciences
full name
- Tushar A. Shah, MD, MPH
Other
recognition and awards
-
2019- Faculty award for excellence in teaching, CHKD/EVMS, Norfolk, VA
2018- Faculty award for excellence in research, CHKD/EVMS, Norfolk, VA
2017- Professional Enrichment and Growth award, EVMS, Norfolk, VA