A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology Review

authors

publication date

  • May 1, 2018

webpage

published in

keywords

  • SINA and SIAH family of RING domain E3 ligases
  • evolutionary conservation
  • oncogenic K-RAS mutations
  • oncogenic K-RAS pathway activation
  • oncogenic K-RAS-driven tumor relapse and metastasis
  • pancreatic tumor vulnerability
  • signaling gatekeeper
  • ubiquitin-mediated proteolysis

volume

  • 10

issue

  • 5