A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology Review

Open Access

author list

  • Van Sciver, Robert E., Lee, Michael P., Lee, Caroline Dasom, Lafever, Alex C., Svyatova, Elizaveta, Kanda, Kevin, Collier, Amber L., van Reesema, Lauren L. Siewertsz, Tang-Tan, Angela M., Zheleva, Vasilena, Bwayi, Monicah N., Bian, Minglei, Schmidt, Rebecca L., Matrisian, Lynn M., Petersen, Gloria M., Tang, Amy H.

authors

publication date

  • May 1, 2018

webpage

published in

author keyword

  • SINA and SIAH family of RING domain E3 ligases
  • evolutionary conservation
  • oncogenic K-RAS mutations
  • oncogenic K-RAS pathway activation
  • oncogenic K-RAS-driven tumor relapse and metastasis
  • pancreatic tumor vulnerability
  • signaling gatekeeper
  • ubiquitin-mediated proteolysis

category

keywords

  • SINA and SIAH family of RING domain E3 ligases
  • evolutionary conservation
  • oncogenic K-RAS mutations
  • oncogenic K-RAS pathway activation
  • oncogenic K-RAS-driven tumor relapse and metastasis
  • pancreatic tumor vulnerability
  • signaling gatekeeper
  • ubiquitin-mediated proteolysis

volume

  • 10

issue

  • 5