Tang, Amy H.

Tang, Amy H.
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tangah@evms.edu

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selected publications

2020

Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Full Text via DOI: 10.36959/739/525 PMID: 32542231
2019

Controlling and conquering incurable metastatic cancer by targeting the major tumor-driving K-RAS/SIAH pathway activation to stratify patients, identify resistant tumor clones, quantify therapy efficacy, forecast tumor relapse, and predict patient survival in the neoadjuvant settings. CLINICAL & EXPERIMENTAL METASTASIS. 146-147.
2019

Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: "Next-day" gene therapy versus standard "two-step" approach. BONE. 128.
Full Text via DOI: 10.1016/j.bone.2019.08.005 PMID: 31398502
2019

Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells. HUMAN GENE THERAPY. 30:906-917.
Full Text via DOI: 10.1089/hum.2018.054 PMID: 30773946
2019

Regional gene therapy with 3D printed scaffolds to heal critical sized bone defects in a rat model. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 107:2174-2182.
Full Text via DOI: 10.1002/jbm.a.36727 PMID: 31112357
2018

Conquering undruggable oncogenic K-RAS-driven incurable metastatic cancer, and delivering precision medicine at neoadjuvant settings. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2018-584
2018

A porcine model of neurofibromatosis type 1 that mimics the human disease. JCI INSIGHT. 3.
Full Text via DOI: 10.1172/jci.insight.120402 PMID: 29925695
2018

A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology. CANCERS.
Full Text via DOI: 10.3390/cancers10050142 PMID: 29757973
2018

3D printed hyperelastic "bone" scaffolds and regional gene therapy: A novel approach to bone healing. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 106:1104-1110.
Full Text via DOI: 10.1002/jbm.a.36310 PMID: 29266747
2018

Cryopreservation of Human Adipose-Derived Stem Cells for Use in Ex Vivo Regional Gene Therapy for Bone Repair. HUMAN GENE THERAPY METHODS. 29:269-277.
Full Text via DOI: 10.1089/hgtb.2018.191 PMID: 30280937
2018

Gene Therapy for Bone Repair Using Human Cells: Superior Osteogenic Potential of Bone Morphogenetic Protein 2-Transduced Mesenchymal Stem Cells Derived from Adipose Tissue Compared to Bone Marrow. HUMAN GENE THERAPY. 29:507-519.
Full Text via DOI: 10.1089/hum.2017.097 PMID: 29212377
2017

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction. CANCER RESEARCH. 77:4328-4341.
Full Text via DOI: 10.1158/0008-5472.CAN-16-3143 PMID: 28720574
2017

Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa. BMC EVOLUTIONARY BIOLOGY. 17.
Full Text via DOI: 10.1186/s12862-017-1024-x PMID: 28784114
2017

Blocking SIAH Proteolysis, an Important K-RAS Vulnerability, to Control and Eradicate K-RAS-Driven Metastatic Cancer. Conquering RAS. 213-232.
Full Text via DOI: 10.1016/b978-0-12-803505-4.00012-6
2016

SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer. EBIOMEDICINE. 11:183-198.
Full Text via DOI: 10.1016/j.ebiom.2016.08.014 PMID: 27569656
2016

Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect. BONE. 84:93-103.
Full Text via DOI: 10.1016/j.bone.2015.12.052 PMID: 26723577
2016

RAS pathway biomarkers for breast cancer prognosis. Women's Cancer Biomarkers. 18-23.
2016

RAS pathway biomarkers for breast cancer prognosis.. Clinical laboratory international. 18-23.
PMID: 28579913
2015

Inhibition of late-stage tumor growth of human pancreatic and triple-negative breast cancer by blocking the most downstream "gatekeeper" signaling module, SIAH E3 ligase, in the oncogenic ERBB/K-RAS signaling pathway. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2015-4366
2015

Proteomic analysis of SIAH2 E3 ligase complex in oncogenic K-Ras-driven cell transformation in human cancer. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2015-2008
2015

NMDA receptor activation regulates sociability by its effect on mTOR signaling activity. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 60:60-65.
Full Text via DOI: 10.1016/j.pnpbp.2015.02.009 PMID: 25703582
2015

Developing a new and potent anti-K-RAS strategy by inhibiting SIAH E3 ligase, the most downstream "gatekeeper" in the oncogenic K-RAS signal pathway, to block well-established pancreatic tumor growth. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.PANCA2014-B70
2015

Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1 alpha pathway to predict survival in resectable pancreatic cancer. BRITISH JOURNAL OF CANCER. 112:514-522.
Full Text via DOI: 10.1038/bjc.2014.659 PMID: 25584484
2015

Combination Therapy With PTH and DBM Cannot Heal a Critical Sized Murine Femoral Defect. JOURNAL OF ORTHOPAEDIC RESEARCH. 33:1242-1249.
Full Text via DOI: 10.1002/jor.22896 PMID: 25877402
2015

Systemic Administration of Sclerostin Antibody Enhances Bone Morphogenetic Protein-Induced Femoral Defect Repair in a Rat Model. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME. 97A:1852-1859.
Full Text via DOI: 10.2106/JBJS.O.00171 PMID: 26582615
2014

Attacking the most downstream "gatekeeper," the SIAH-dependent proteolytic machinery, in the oncogenic ERBB/K-RAS signaling pathway to block tumorigenesis and control metastasis in human cancer. MOLECULAR CANCER RESEARCH.
Full Text via DOI: 10.1158/1557-3125.RASONC14-A26
2014

Inhibiting SIAH2 E3 ligase function disrupts focal adhesion and cell junction, inhibits cell mobility and attachment, and blocks tumor invasion and metastasis in oncogenic K-Ras-driven tumors. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2014-1965
2014

Inhibition of SIAH E3 ligase function leads to increased cell death in metastatic human cancer cells. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2014-4442
2014

Proteomic analysis of SIAH2 E3 ligase complex in oncogenic K-Ras-driven cell transformation and oncogenesis. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2014-4439
2014

Inhibition of Established Pancreatic and Triple Negative Breast Tumor Growth by Blocking the Most Downstream Signaling Module, SIAH, in the Oncogenic ERBB/K-RAS Signaling Pathway. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. S136-S137.
2014

NMDA receptors on the surface of cancer cells: Target for chemotherapy?. BIOMEDICINE & PHARMACOTHERAPY. 493-496.
Full Text via DOI: 10.1016/j.biopha.2014.03.012 PMID: 24751001
2014

Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders. BRAIN RESEARCH BULLETIN. 100:70-75.
Full Text via DOI: 10.1016/j.brainresbull.2013.11.005 PMID: 24295733
2014

Stopping metastasis in its tracks. International Innovation. 42-44.
2014

Inhibition of Established Pancreatic and Triple Negative Breast Tumor Growth by Blocking the Most Downstream Signaling Module, SIAH, in the Oncogenic ERBB/K-RAS Signaling Pathway. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 219:S136-S137.
Full Text via DOI: 10.1016/j.jamcollsurg.2014.07.327
2013

Rapamycin, an Inhibitor of mTORC1 Signaling Activity, Improved Measures of Sociability in the BTBR T+Itpr3tf/J Mouse Model of Autism Spectrum Disorder. NEUROPSYCHOPHARMACOLOGY. S567-S568.
2013

Attacking the most downstream "gatekeeper" signaling module in the oncogenic ERBB/K-RAS signaling pathway to block tumorigenesis and metastasis in human cancer. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.FBCR13-C62
2013

D-Cycloserine improves sociability in the BTBR T+Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling. BRAIN RESEARCH BULLETIN. 96:62-70.
Full Text via DOI: 10.1016/j.brainresbull.2013.05.003 PMID: 23685206
2013

SIAH as a Promising Biomarker Predictive of Cancer Cell Response to Effective Chemotherapy. ANNALS OF SURGICAL ONCOLOGY. S103-S104.
2011

Oncogenic K-RAS activation promotes cell motility, invasion, tumor growth and cancer metastasis via its most downstream signaling module, the SIAH2-ependent proteolytic machinery, in the highly aggressive and metastatic human cancer cells. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2011-2335
2011

Targeting SIAH2-dependent proteolysis downstream of the HER2/EGFR/RAS signaling pathway to inhibit tumorigenesis and metastasis of highly invasive human breast cancer. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2011-1659
2011

The SIAH2-SMAD2/3/4 antagonism downstream of the K-RAS and TGF beta signaling pathways during tumor initiation, progression and metastasis of human cancer. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2011-1980
2011

SIAH-dependent proteolysis modulates focal adhesion, cell junction, and cell motility in response to oncogenic K-RAS activation in human cancer cells. CLINICAL & EXPERIMENTAL METASTASIS. 179-179.
2011

Are you my friends or are you my enemies?
Full Text via DOI: 10.4161/self.20137 PMID: 22496931
2011

Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells.
Full Text via DOI: 10.4161/self.17882 PMID: 22496930
2011

Drosophila melanogaster: A new model to study cisplatin-induced neurotoxicity. NEUROBIOLOGY OF DISEASE. 43:330-337.
Full Text via DOI: 10.1016/j.nbd.2011.03.022 PMID: 21514385
2011

Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma. BREAST CANCER RESEARCH AND TREATMENT. 129:717-724.
Full Text via DOI: 10.1007/s10549-010-1254-8 PMID: 21088888
2010

Inhibit SIAH E3 Ligase, a Downstream Signaling Module Required for the HER2/EGFR/RAS Signal Transduction, To Block Tumorigenesis and Metastasis of Highly Invasive Human Breast Cancers. CANCER RESEARCH.
Full Text via DOI: 10.1158/0008-5472.SABCS10-P6-15-14
2009

Protease-Dependent Activation of the Drosophila IMD Pathway in Response to Gram-Negative Bacterial Infection. Innate Immunity 1. 1-15.
2008

Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth.. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 100:1606-29.
Full Text via DOI: 10.1093/jnci/djn365 PMID: 19001609
2008

Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization cascades in Drosophila.. FASEB JOURNAL. 22:918-29.
Full Text via DOI: 10.1096/fj.06-7907com PMID: 18308747
2007

Accommodation of grafts: implications for health and disease.. Human immunology. 68:645-51.
Full Text via DOI: 10.1016/j.humimm.2007.04.003 PMID: 17678718
2007

Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.. CANCER RESEARCH. 67:11798-810.
Full Text via DOI: 10.1158/0008-5472.can-06-4471 PMID: 18089810
2007

Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions.. JOURNAL OF LEUKOCYTE BIOLOGY. 82:282-5.
Full Text via DOI: 10.1189/jlb.1206752 PMID: 17495051
2003

Evolutionary clues to the functions of the Toll-like family as surveillance receptors.. Trends in immunology. 24:19-24.
Full Text via DOI: 10.1016/s1471-4906(02)00014-5 PMID: 12495720
2001

Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian.. Development (Cambridge, England). 128:801-13.
PMID: 11171404
1998

A genetic screen to identify components of the sina signaling pathway in Drosophila eye development.. Genetics. 148:277-86.
PMID: 9475739
1997

PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.. Cell. 90:459-67.
Full Text via DOI: 10.1016/s0092-8674(00)80506-1 PMID: 9267026
1997

Signal transduction downstream from Ras in Drosophila.. Cold Spring Harbor symposia on quantitative biology. 62:347-52.
PMID: 9598368
1995

Pentobarbital-induced changes in Drosophila glutathione S-transferase D21 mRNA stability.. The Journal of biological chemistry. 270:13819-25.
Full Text via DOI: 10.1074/jbc.270.23.13819 PMID: 7775439
1994

Biochemical characterization of Drosophila glutathione S-transferases D1 and D21.. The Journal of biological chemistry. 269:27876-84.
PMID: 7961718
1988

The Effect of hemoglobin on the fluidity of human erythrocyte membrane. Acta Biochimica et Biophysica Sinica 4. 129-133.
The phylogenetic functional conservation of Drosophila Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in Drosophila eye development
Full Text via DOI: 10.1101/2020.04.28.067074

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Amy H. Tang

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