Overview
overview
- Dr. Marybeth Hughes graduated from Eastern Virginia Medical school (EVMS) and completed surgical training at Eastern Virginia Medical School graduate school of medicine. Following surgical training, she did a Surgical Oncology Fellowship at the National Cancer Institute(NCI)at the National Institutes of Health (NIH). At the completion of training she served as Surgical Oncologist at the NCI, NIH for 12 years. She returned to Norfolk, VA to serve as the Chief of Surgical Oncology at EVMS in 2016. She currently is part of several leadership teams for EVMS and Sentara in Cancer research and cancer care.
Publications
selected publications
-
2020A Review of Nonantibiotic Agents to Prevent Urinary Tract Infections in Older Women.. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 21:46-54.Full Text via DOI: 10.1016/j.jamda.2019.04.018 PMID: 31227473
-
2020Bayesian clinical decision support-guided versus clinician-guided vancomycin dosing in attainment of targeted pharmacokinetic parameters in a paediatric population.. The Journal of antimicrobial chemotherapy. 75:434-437.Full Text via DOI: 10.1093/jac/dkz444 PMID: 31670812
-
2019Pilot Study Comparing Systemic and Tissue Pharmacokinetics of Irinotecan and Metabolites after Hepatic Drug-Eluting Chemoembolization. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. 30:19-22.Full Text via DOI: 10.1016/j.jvir.2018.06.023 PMID: 30527657
-
2018A Phase II Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Adrenocortical Carcinoma. JOURNAL OF SURGICAL RESEARCH. 232:383-388.Full Text via DOI: 10.1016/j.jss.2018.06.012 PMID: 30463745
-
2018A Rare Adrenal Incidentaloma That Mimics Adrenocortical Carcinoma. CASE REPORTS IN SURGERY.Full Text via DOI: 10.1155/2018/9607972 PMID: 29984033
-
2017Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma. JOURNAL OF HEPATOLOGY. 66:545-551.Full Text via DOI: 10.1016/j.jhep.2016.10.029 PMID: 27816492
-
2017Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma.. ANNALS OF SURGICAL ONCOLOGY. 24:135-141.Full Text via DOI: 10.1245/s10434-016-5537-0 PMID: 27638681
-
2017Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients.. ANNALS OF SURGICAL ONCOLOGY. 24:947-951.Full Text via DOI: 10.1245/s10434-017-5768-8 PMID: 28144760
-
2016Results of a Randomized Controlled Multicenter Phase III Trial of Percutaneous Hepatic Perfusion Compared with Best Available Care for Patients with Melanoma Liver Metastases. ANNALS OF SURGICAL ONCOLOGY. 23:1309-1319.Full Text via DOI: 10.1245/s10434-015-4968-3 PMID: 26597368
-
2016Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors. AMERICAN JOURNAL OF SURGERY. 212:40-46.Full Text via DOI: 10.1016/j.amjsurg.2015.07.031 PMID: 26782807
-
2016Prospective evaluation and treatment of familial carcinoid small intestine neuroendocrine tumors (SI-NETs).. SURGERY. 159:350-6.Full Text via DOI: 10.1016/j.surg.2015.05.041 PMID: 26454678
-
2016Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.. JOURNAL OF CLINICAL ONCOLOGY. 34:2389-97.Full Text via DOI: 10.1200/jco.2016.66.7220 PMID: 27217459
-
2015A Simplified Preoperative Assessment Predicts Complete Cytoreduction and Outcomes in Patients with Low-Grade Mucinous Adenocarcinoma of the Appendix. ANNALS OF SURGICAL ONCOLOGY. 22:3640-3646.Full Text via DOI: 10.1245/s10434-015-4446-y PMID: 25698402
-
2015Unknown primary nasopharyngeal melanoma presenting as severe recurrent epistaxis and hearing loss following treatment and remission of metastatic disease: A case report and literature review. INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS. 232-235.Full Text via DOI: 10.1016/j.ijscr.2015.03.053 PMID: 25898283
-
2015A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase.. Gastroenterology. 149:67-78.Full Text via DOI: 10.1053/j.gastro.2015.04.008 PMID: 25865046
-
2015A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response.. CLINICAL CANCER RESEARCH. 21:1019-27.Full Text via DOI: 10.1158/1078-0432.ccr-14-2708 PMID: 25538264
-
2015Entropy <i>vs.</i> Energy Waveform Processing: A Comparison Based on the Heat Equation.Full Text via DOI: 10.3390/e17063518 PMID: 27110093
-
2015Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma.. CLINICAL CANCER RESEARCH. 21:2278-88.Full Text via DOI: 10.1158/1078-0432.ccr-14-2085 PMID: 25695689
-
2014Glioma diagnostics and biomarkers: an ongoing challenge in the field of medicine and science.. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 14:439-52.Full Text via DOI: 10.1586/14737159.2014.905202 PMID: 24746164
-
2013A Novel Nomogram for Peritoneal Mesothelioma Predicts Survival. ANNALS OF SURGICAL ONCOLOGY. 20:555-561.Full Text via DOI: 10.1245/s10434-012-2651-5 PMID: 23233234
-
2013Treatment factors associated with long-term survival after cytoreductive surgery and regional chemotherapy for patients with malignant peritoneal mesothelioma. SURGERY. 153:779-786.Full Text via DOI: 10.1016/j.surg.2013.01.001 PMID: 23489943
-
2013Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.. Journal of immunotherapy (Hagerstown, Md. : 1997). 36:133-51.Full Text via DOI: 10.1097/cji.0b013e3182829903 PMID: 23377668
-
2013Kba.62 and S100 protein expression in cytologic samples of metastatic malignant melanoma.. Diagnostic cytopathology. 41:847-51.Full Text via DOI: 10.1002/dc.22948 PMID: 23554410
-
2013Orthopaedic injuries from deer stands and their functional outcomes.. Journal of surgical orthopaedic advances. 22:123-6.Full Text via DOI: 10.3113/jsoa.2013.0123 PMID: 23628564
-
2013Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.. JOURNAL OF CLINICAL ONCOLOGY. 31:2152-9.Full Text via DOI: 10.1200/jco.2012.46.6441 PMID: 23650429
-
2013Utility of intraoperative parathyroid hormone monitoring in patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial parathyroidectomy.. World journal of surgery. 37:1966-72.Full Text via DOI: 10.1007/s00268-013-2054-1 PMID: 23722465
-
2012CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma.. CLINICAL CANCER RESEARCH. 18:2039-47.Full Text via DOI: 10.1158/1078-0432.ccr-11-1823 PMID: 22271879
-
2012Rate of clinically significant postoperative pancreatic fistula in pancreatic neuroendocrine tumors.. World journal of surgery. 36:1517-26.Full Text via DOI: 10.1007/s00268-012-1598-9 PMID: 22526042
-
2011T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis. MOLECULAR THERAPY. 19:620-626.Full Text via DOI: 10.1038/mt.2010.272 PMID: 21157437
-
2011Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior.. PANCREAS. 40:551-6.Full Text via DOI: 10.1097/mpa.0b013e318214fb77 PMID: 21499209
-
2011Comparison of 6-18F-fluoro-L-DOPA, 18F-2-deoxy-D-glucose, CT, and MRI in patients with pancreatic neuroendocrine neoplasms with von Hippel-Lindau disease.. SURGERY. 150:1122-8.Full Text via DOI: 10.1016/j.surg.2011.09.048 PMID: 22136831
-
2011Use of smoothing splines for analysis of backscattered ultrasonic waveforms: application to monitoring of steroid treatment of dystrophic mice.. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 58:2361-9.Full Text via DOI: 10.1109/tuffc.2011.2093 PMID: 22083769
-
2010Liver Resection for Metastatic Melanoma with Postoperative Tumor-Infiltrating Lymphocyte Therapy. ANNALS OF SURGICAL ONCOLOGY. 17:163-170.Full Text via DOI: 10.1245/s10434-009-0677-0 PMID: 19777192
-
2010Acupuncture treatment for persistent hiccups in patients with cancer.. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE. 16:811-6.Full Text via DOI: 10.1089/acm.2009.0456 PMID: 20575702
-
2010Angiogenesis imaging with vascular-constrained particles: the why and how.. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 37 Suppl 1:S114-26.Full Text via DOI: 10.1007/s00259-010-1502-5 PMID: 20617434
-
2010Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors.. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 1890-5.Full Text via DOI: 10.1109/tuffc.2010.1630 PMID: 20679020
-
2010CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma.. CLINICAL CANCER RESEARCH. 16:6122-31.Full Text via DOI: 10.1158/1078-0432.ccr-10-1297 PMID: 20668005
-
2010Exercise-induced nausea and vomiting: another sign and symptom of pheochromocytoma and paraganglioma.. ENDOCRINE. 37:403-7.Full Text via DOI: 10.1007/s12020-010-9319-3 PMID: 20960160
-
2010The use of implantable bone stimulators in nonunion treatment.. ORTHOPEDICS. 33.Full Text via DOI: 10.3928/01477447-20100129-15 PMID: 20349861
-
2010Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions.. Angiogenesis. 13:189-202.Full Text via DOI: 10.1007/s10456-010-9166-0 PMID: 20411320
-
2009Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.. BLOOD. 114:535-46.Full Text via DOI: 10.1182/blood-2009-03-211714 PMID: 19451549
-
2009Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation.. Journal of pediatric hematology/oncology. 31:142-4.Full Text via DOI: 10.1097/mph.0b013e31819146e5 PMID: 19194203
-
2009Verteporfin photodynamic therapy combined with intravitreal bevacizumab for neovascular age-related macular degeneration.. OPHTHALMOLOGY. 116:747-55, 755.e1.Full Text via DOI: 10.1016/j.ophtha.2008.12.057 PMID: 19243834
-
2008Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.. JOURNAL OF CLINICAL ONCOLOGY. 26:5233-9.Full Text via DOI: 10.1200/jco.2008.16.5449 PMID: 18809613
-
2008High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.. Cancer. 113:293-301.Full Text via DOI: 10.1002/cncr.23552 PMID: 18457330
-
2008The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism.. SURGERY. 144:878-83; discussion 883-4.Full Text via DOI: 10.1016/j.surg.2008.08.031 PMID: 19040992
-
2008Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.. CLINICAL CANCER RESEARCH. 14:5610-8.Full Text via DOI: 10.1158/1078-0432.ccr-08-0116 PMID: 18765555
-
2007Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade.. CLINICAL CANCER RESEARCH. 13:6681-8.Full Text via DOI: 10.1158/1078-0432.ccr-07-0187 PMID: 17982122
-
2007Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging.. The Journal of the Acoustical Society of America. 121:3542-57.Full Text via DOI: 10.1121/1.2722050 PMID: 17552706
-
2007Sensitive ultrasonic delineation of steroid treatment in living dystrophic mice with energy-based and entropy-based radio frequency signal processing.. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 54:2291-9.Full Text via DOI: 10.1109/tuffc.2007.533 PMID: 18051163
-
2007Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver.. Ultrasound in medicine & biology. 33:1236-43.Full Text via DOI: 10.1016/j.ultrasmedbio.2007.02.007 PMID: 17467153
-
2006Cancer regression in patients after transfer of genetically engineered lymphocytes.. SCIENCE. 314:126-9.Full Text via DOI: 10.1126/science.1129003 PMID: 16946036
-
2006Characterization of digital waveforms using thermodynamic analogs: detection of contrast-targeted tissue in vivo.. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 53:1609-16.Full Text via DOI: 10.1109/tuffc.2006.1678189 PMID: 16964911
-
2006Enhanced fracture and soft-tissue healing by means of anabolic dietary supplementation.. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME. 88:2386-94.Full Text via DOI: 10.2106/jbjs.f.00507 PMID: 17079395
-
2006Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.. JOURNAL OF CLINICAL ONCOLOGY. 24:2283-9.Full Text via DOI: 10.1200/jco.2005.04.5716 PMID: 16710025
-
2006Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticles.. Nanomedicine (London, England). 1:321-9.Full Text via DOI: 10.2217/17435889.1.3.321 PMID: 17716162
-
2006Safety and efficacy of intravitreal bevacizumab followed by pegaptanib maintenance as a treatment regimen for age-related macular degeneration.. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye. 37:446-54.Full Text via DOI: 10.3928/15428877-20061101-01 PMID: 17152537
-
2005Acoustic characterization in whole blood and plasma of site-targeted nanoparticle ultrasound contrast agent for molecular imaging.. The Journal of the Acoustical Society of America. 117:964-72.Full Text via DOI: 10.1121/1.1810251 PMID: 15759715
-
2005Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer.. Journal of immunotherapy (Hagerstown, Md. : 1997). 28:593-8.Full Text via DOI: 10.1097/01.cji.0000178913.41256.06 PMID: 16224277
-
2005Molecular analyses of mycobacteria other than the M. tuberculosis complex isolated from Northern Ireland cattle.. Veterinary microbiology. 108:101-12.Full Text via DOI: 10.1016/j.vetmic.2005.03.001 PMID: 15917138
-
2005Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine.. JOURNAL OF IMMUNOLOGY. 175:7226-34.Full Text via DOI: 10.4049/jimmunol.175.11.7226 PMID: 16301627
-
2005Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions.. HUMAN GENE THERAPY. 16:457-72.Full Text via DOI: 10.1089/hum.2005.16.457 PMID: 15871677
-
2005Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma.. JOURNAL OF IMMUNOLOGY. 175:6169-76.Full Text via DOI: 10.4049/jimmunol.175.9.6169 PMID: 16237114
-
2004Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles.. Investigative radiology. 39:187-95.Full Text via DOI: 10.1097/01.rli.0000115926.96796.75 PMID: 15076011
-
2004Mycobacterium nonchromogenicum in nasal mucus from cattle in a herd infected with bovine tuberculosis.. Veterinary microbiology. 99:281-5.Full Text via DOI: 10.1016/j.vetmic.2003.12.006 PMID: 15066730
-
2004PCR studies of feline leprosy cases.. Journal of feline medicine and surgery. 6:235-43.Full Text via DOI: 10.1016/j.jfms.2003.09.003 PMID: 15265479
-
2004Pseudo-Meigs' syndrome secondary to isolated colorectal metastasis to ovary: a case report and review of the literature.. Gynecologic oncology. 93:248-51.Full Text via DOI: 10.1016/j.ygyno.2003.12.025 PMID: 15047245
-
2003High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens.. JOURNAL OF IMMUNOLOGY. 171:3287-95.Full Text via DOI: 10.4049/jimmunol.171.6.3287 PMID: 12960359
-
2002Destruction of contrast agent microbubbles in the ultrasound field: the fate of the microbubble shell and the importance of the bubble gas content.. ACADEMIC RADIOLOGY. 9 Suppl 1:S41-5.Full Text via DOI: 10.1016/s1076-6332(03)80393-8 PMID: 12019891
-
2001Detection of Mycobacterium bovis in bovine clinical specimens using real-time fluorescence and fluorescence resonance energy transfer probe rapid-cycle PCR.. JOURNAL OF CLINICAL MICROBIOLOGY. 39:1272-8.Full Text via DOI: 10.1128/jcm.39.4.1272-1278.2001 PMID: 11283040
-
2001Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs.. Australian veterinary journal. 79:30-6.Full Text via DOI: 10.1111/j.1751-0813.2001.tb10635.x PMID: 11221566
-
2000Carcinoid TumorsPMID: 25905385
-
2000GastrinomaPMID: 25905301
-
2000Identification by 16S rRNA gene analyses of a potential novel mycobacterial species as an etiological agent of canine leproid granuloma syndrome.. JOURNAL OF CLINICAL MICROBIOLOGY. 38:953-9.PMID: 10698979
-
2000
-
2000On a time-domain representation of the Kramers-Kronig dispersion relations. The Journal of the Acoustical Society of America. 108:2114-9.Full Text via DOI: 10.1121/1.1315294 PMID: 11108348
-
2000Simultaneous detection and strain differentiation of Mycobacterium bovis directly from bovine tissue specimens by spoligotyping.. Veterinary microbiology. 74:227-36.Full Text via DOI: 10.1016/s0378-1135(00)00189-9 PMID: 10808091
-
1999Broadband measurement of the scattering-to-attenuation ratio for Albunex at 37 degrees C.. Ultrasound in medicine & biology. 25:1321-4.Full Text via DOI: 10.1016/s0301-5629(99)00077-0 PMID: 10576274
-
1999Disseminated Mycobacterium genavense infection in a FIV-positive cat.. Journal of feline medicine and surgery. 1:23-9.Full Text via DOI: 10.1016/s1098-612x(99)90006-2 PMID: 11919012
-
1999Effects of transducer frequency and output power on the ultrasonographic contrast produced by Optison using fundamental and harmonic imaging techniques.. JOURNAL OF ULTRASOUND IN MEDICINE. 18:753-62.Full Text via DOI: 10.7863/jum.1999.18.11.753 PMID: 10547107
-
1998Direct video-microscopic observation of the dynamic effects of medical ultrasound on ultrasound contrast microspheres.. Investigative radiology. 33:863-70.Full Text via DOI: 10.1097/00004424-199812000-00004 PMID: 9851820
-
1998Spacer oligotyping of Mycobacterium bovis isolates compared to typing by restriction fragment length polymorphism using PGRS, DR and IS6110 probes.. Veterinary microbiology. 61:111-20.Full Text via DOI: 10.1016/s0378-1135(98)00178-3 PMID: 9646470
-
1998Targeting of ultrasound contrast material: selective imaging of microbubbles in vitro.. ACADEMIC RADIOLOGY. 5 Suppl 1:S243-6.Full Text via DOI: 10.1016/s1076-6332(98)80118-9 PMID: 9561091
-
1997Development of mycobacterial species-specific DNA probes by subtraction hybridization.. FEMS microbiology letters. 156:31-6.Full Text via DOI: 10.1111/j.1574-6968.1997.tb12701.x PMID: 9368357
-
1996Vaccination of the badger (Meles meles) against Mycobacterium bovis.. Veterinary microbiology. 51:363-79.Full Text via DOI: 10.1016/0378-1135(96)00051-x PMID: 8870197
-
1994Genomic fingerprinting of Mycobacterium bovis from cattle by restriction fragment length polymorphism analysis.. JOURNAL OF CLINICAL MICROBIOLOGY. 32:2387-92.PMID: 7814471
-
1993Effect of streptozotocin-induced diabetes on magnesium inhibition of contractions of the rat uterus and G.I. tract.. Biochemical Society transactions. 21:487S.Full Text via DOI: 10.1042/bst021487s PMID: 8132054
-
1993Proton magnetic resonance spectroscopy of vitreal changes in experimental streptococcal endophthalmitis.. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 231:402-4.Full Text via DOI: 10.1007/bf00919648 PMID: 8406065
-
1988
-
1988The truth about condoms.. SIECUS report. 17:1-8.PMID: 12342103
-
1982Maternal and cord blood background mercury levels: a longitudinal surveillance.. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 143:440-3.Full Text via DOI: 10.1016/0002-9378(82)90087-4 PMID: 7091210
Research
research overview
- My research Topics of Interest are in Surgical Oncology and Endocrine Surgery. Please see cv for prior published research. Melanoma, Neuroendocrine tumors and hepatobiliary pathology are of particular interest to my clinical practice. I have been involved in several different collaborative projects over time with many different researchers to include students, residents, post doctoral fellows and PhD researchers and physicians.
projects
-
Current Project
Contact
preferred title
- Chief of Surgical Oncology
full name
- Marybeth S. Hughes, MD
