Dobrian, Anca D.

Dobrian, Anca D.
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Positions

Professor of Physiological Sciences, Physiological Sciences

Contact Info

dobriaad@evms.edu

selected publications

2019

Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment. FRONTIERS IN ENDOCRINOLOGY. 10.
Full Text via DOI: 10.3389/fendo.2019.00311 PMID: 31156558
2019

Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 39:2168-2191.
Full Text via DOI: 10.1161/ATVBAHA.119.312826 PMID: 31434495
2019

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications. PHARMACOLOGY & THERAPEUTICS. 100-110.
Full Text via DOI: 10.1016/j.pharmthera.2018.10.010 PMID: 30347209
2018

Effect of Diet and Aging in Adipose Tissue and Liver Inflammation in Diamond (TM) Mouse Model of Nash. HEPATOLOGY. 1016A-1017A.
2018

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
Full Text via DOI: 10.3791/57804 PMID: 30080200
2018

Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice. PROSTAGLANDINS & OTHER LIPID MEDIATORS. 136:23-32.
Full Text via DOI: 10.1016/j.prostaglandins.2018.03.003 PMID: 29605541
2017

STAT4 Regulates the CD8(+) Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr(-/-) Mice. JOURNAL OF IMMUNOLOGY. 199:3453-3465.
Full Text via DOI: 10.4049/jimmunol.1601429 PMID: 29055004
2017

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. PLOS ONE. 12.
Full Text via DOI: 10.1371/journal.pone.0170500 PMID: 28107529
2017

Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation. MEDIATORS OF INFLAMMATION.
Full Text via DOI: 10.1155/2017/5420718 PMID: 28400678
2016

Age-associated vascular inflammation promotes monocytosis during atherogenesis. AGING CELL. 15:766-777.
Full Text via DOI: 10.1111/acel.12488 PMID: 27135421
2016

Lipids and immunoinflammatory pathways of beta cell destruction. DIABETOLOGIA. 673-678.
Full Text via DOI: 10.1007/s00125-016-3890-y PMID: 26868492
2015

STAT4 deficiency reduces the development of atherosclerosis in mice. ATHEROSCLEROSIS. 243:169-178.
Full Text via DOI: 10.1016/j.atherosclerosis.2015.08.045 PMID: 26386214
2015

STAT4 contributes to adipose tissue inflammation and atherosclerosis. JOURNAL OF ENDOCRINOLOGY. 227:13-24.
Full Text via DOI: 10.1530/JOE-15-0098 PMID: 26285907
2015

Proton pump inhibitors: the culprit for Barrett's esophagus?. FRONTIERS IN ONCOLOGY. 373.
Full Text via DOI: 10.3389/fonc.2014.00373 PMID: 25621278
2014

Adipose Tissue 12/15 Lipoxygenase Pathway in Human Obesity and Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:E1713-E1720.
Full Text via DOI: 10.1210/jc.2013-4461 PMID: 24955608
2014

Omental fat from obese and obese diabetic patients dys-regulates vascular function by NF-kappa B, PARP-1 and interleukin 12-dependent mechanism. FASEB JOURNAL.
2013

STAT4 Deficiency Reduces Obesity-Induced Insulin Resistance and Adipose Tissue Inflammation. DIABETES. 62:4109-4121.
Full Text via DOI: 10.2337/db12-1275 PMID: 23939393
2013

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. DIABETES OBESITY & METABOLISM. 117-129.
Full Text via DOI: 10.1111/dom.12161 PMID: 24003928
2013

12-and 15-lipoxygenases in adipose tissue inflammation. PROSTAGLANDINS & OTHER LIPID MEDIATORS. 104:84-92.
Full Text via DOI: 10.1016/j.prostaglandins.2012.07.004 PMID: 22951339
2013

Islet inflammation: a unifying target for diabetes treatment?. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 351-360.
Full Text via DOI: 10.1016/j.tem.2013.01.007 PMID: 23484621
2012

ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for L-arginine. KIDNEY INTERNATIONAL. 722-724.
Full Text via DOI: 10.1038/ki.2011.496 PMID: 22460653
2012

Accelerated Atherosclerosis in Apoe(-/-) Mice Heterozygous for the Insulin Receptor and the Insulin Receptor Substrate-1. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 32:247-U172.
Full Text via DOI: 10.1161/ATVBAHA.111.240358 PMID: 22199371
2012

A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue.. FRONTIERS IN ENDOCRINOLOGY. 108.
Full Text via DOI: 10.3389/fendo.2012.00108 PMID: 22969750
2011

Different Natriuretic Responses in Obese and Lean Rats in Response to Nitric Oxide Reduction. AMERICAN JOURNAL OF HYPERTENSION. 24:943-950.
Full Text via DOI: 10.1038/ajh.2011.79 PMID: 21562602
2011

Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 300:E410-E421.
Full Text via DOI: 10.1152/ajpendo.00463.2010 PMID: 21081706
2011

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 300:E175-E187.
Full Text via DOI: 10.1152/ajpendo.00203.2010 PMID: 20978234
2011

Functional and pathological roles of the 12-and 15-lipoxygenases. PROGRESS IN LIPID RESEARCH. 115-131.
Full Text via DOI: 10.1016/j.plipres.2010.10.005 PMID: 20970452
2010

Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 403:485-490.
Full Text via DOI: 10.1016/j.bbrc.2010.11.065 PMID: 21094135
2010

STAT4 Deficiency Alters the Immune Composition and Inflammation in Adipose Tissue and Improves the Metabolic Phenotype in Obese Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. E195-E195.
2010

STAT4 Deficiency Reduces Atherosclerosis and Alters the Immune Composition of Visceral Adipose Tissue in Apoe Null Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. E271-E271.
2010

Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice. CIRCULATION. 121:1746-U130.
Full Text via DOI: 10.1161/CIRCULATIONAHA.109.924886 PMID: 20368519
2009

Dipeptidyl Peptidase-4 (DDP-4) Inhibitor Sitagliptin Inhibits Inflammation in Visceral and Peri-aortic Fat in a Mouse Model of Obesity. CIRCULATION. S1165-S1165.
2008

Effect of pioglitazone treatment on renal sodium handling in obese and lean rats on high-fat diet. HYPERTENSION. E88-E88.
2008

Obese and lean rats on high-fat diet have different renal sodium regulation in response to NO depletion. HYPERTENSION. E104-E104.
2008

Natriuretic Responses to Increases in Renal Perfusion Pressure (RPP) in Obesity-Prone Rats are Blunted. FASEB JOURNAL.
2008

The effect of PPAR gamma Activation on the Expression of Renal Proximal Tubule Sodium Transporters NHE3 and Na,K ATPase in vivo and in vitro. FASEB JOURNAL.
2007

PPARgamma modulates the sodium transporters in the renal proximal tubule epithelium in vivo and in vitro. FASEB JOURNAL. A901-A901.
2006

Special issue: PPARs and their agonists in the management of cardiovascular and renal dysfunction associated to obesity and diabetes - Introduction. VASCULAR PHARMACOLOGY. 1-2.
Full Text via DOI: 10.1016/j.vph.2006.01.016
2006

The complex role of PPAR gamma in renal dysfunction in obesity: Managing a Janus-faced receptor. VASCULAR PHARMACOLOGY. 36-45.
Full Text via DOI: 10.1016/j.vph.2006.01.017 PMID: 16716756
2006

PPAR lambda regulates expression of sodium transporters in renal proximal tubule epithelial cells (PTEC) via a NO dependent mechanism. FASEB JOURNAL. A1076-A1076.
2006

Differential expression of genes related to contraction and inflammation in human aortic smooth muscle cells cultured on plastic or 3D-Matrigel. FASEB JOURNAL. A699-A700.
2005

Role of RIHP and renal tubular sodium transporters in volume retention of pregnant rats. AMERICAN JOURNAL OF HYPERTENSION. 18:1375-1383.
Full Text via DOI: 10.1016/j.amjhyper.2005.04.022 PMID: 16202865
2005

Development of a coculture system and use of confocal laser fluorescent microscopy to study human microvascular endothelial cell and mural cell interaction. MICROVASCULAR RESEARCH. 70:43-52.
Full Text via DOI: 10.1016/j.mvr.2005.04.008 PMID: 15967470
2005

Nitric oxide synthase and the renin angiotensin system in the porcine renal microvasculature during postnatal maturation. FASEB JOURNAL. A1149-A1149.
2005

Erk1/2 and c-fos signaling during pressure elevation in isolated resistance arteries. FASEB JOURNAL. A721-A721.

full name

Anca D. Dobrian

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