Taylor-Fishwick, David A.
- Professor and Vice Chair Microbiology and Molecular Cell Biology, Microbiology and Molecular Cell Biology
Contact Info
Publications
selected publications
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2019Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications. PHARMACOLOGY & THERAPEUTICS. 100-110.Full Text via DOI: 10.1016/j.pharmthera.2018.10.010 PMID: 30347209
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2019Small molecule inhibition of NOX-1 reduces diabetes conversion in NOD mice. Integrative Molecular Medicine. 6.Full Text via DOI: 10.15761/imm.1000367
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2018Evaluation of a human placenta-derived hydrogel to support glucose sensitive insulin secretion in human donor islets. Integrative Molecular Medicine. 5.Full Text via DOI: 10.15761/imm.1000339
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2018Identification of a novel compound that protects beta cells and islets from dysfunction associated with inflammatory cytokines. Integrative Molecular Medicine. 5.Full Text via DOI: 10.15761/imm.1000329
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201712-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 102:2789-2797.Full Text via DOI: 10.1210/jc.2017-00267 PMID: 28609824
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2017Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 485:290-294.Full Text via DOI: 10.1016/j.bbrc.2017.02.089 PMID: 28232183
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2016Lipids and immunoinflammatory pathways of beta cell destruction.. DIABETOLOGIA. 673-8.Full Text via DOI: 10.1007/s00125-016-3890-y PMID: 26868492
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2015Interleukin-12 (IL-12)/STAT4 Axis Is an Important Element for beta-Cell Dysfunction Induced by Inflammatory Cytokines. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0142735 PMID: 26555476
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2015Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. DIABETOLOGIA. 58:549-557.Full Text via DOI: 10.1007/s00125-014-3452-0 PMID: 25417214
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2015Inhibition of NADPH oxidase-1 preserves beta cell function. DIABETOLOGIA. 58:113-121.Full Text via DOI: 10.1007/s00125-014-3398-2 PMID: 25277953
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2015Role of NADPH Oxidase in Beta Cell Dysfunction. Islets of Langerhans, 2. ed.. 1-29.Full Text via DOI: 10.1007/978-94-007-6884-0_46-3
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2015Inflammatory Pathways Linked to β Cell Demise in Diabetes. Islets of Langerhans. 989-1045.Full Text via DOI: 10.1007/978-94-007-6686-0_30
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2014Synthesis and Structure-Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase. JOURNAL OF MEDICINAL CHEMISTRY. 57:495-506.Full Text via DOI: 10.1021/jm4016476 PMID: 24393039
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2013Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. DIABETES OBESITY & METABOLISM. 117-129.Full Text via DOI: 10.1111/dom.12161 PMID: 24003928
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2013NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.. FRONTIERS IN ENDOCRINOLOGY. 40.Full Text via DOI: 10.3389/fendo.2013.00040 PMID: 23565109
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2013Production and function of IL-12 in islets and beta cells. DIABETOLOGIA. 56:126-135.Full Text via DOI: 10.1007/s00125-012-2732-9 PMID: 23052055
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2013Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.. PLOS ONE. 8:e56763.Full Text via DOI: 10.1371/journal.pone.0056763 PMID: 23437231
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2013Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway.. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 369:35-41.Full Text via DOI: 10.1016/j.mce.2013.01.011 PMID: 23410839
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2012Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 358:88-95.Full Text via DOI: 10.1016/j.mce.2012.03.004 PMID: 22502743
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2011Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12-Lipoxygenase. JOURNAL OF MEDICINAL CHEMISTRY. 54:5485-5497.Full Text via DOI: 10.1021/jm2005089 PMID: 21739938
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2011Functional and pathological roles of the 12- and 15-lipoxygenases.. PROGRESS IN LIPID RESEARCH. 115-31.Full Text via DOI: 10.1016/j.plipres.2010.10.005 PMID: 20970452
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2011Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia.. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 335:104-9.Full Text via DOI: 10.1016/j.mce.2010.12.026 PMID: 21187123
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2010Harnessing the Pancreatic Stem Cell. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. 39:763-+.Full Text via DOI: 10.1016/j.ecl.2010.08.008 PMID: 21095543
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201012-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets.. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 95:887-93.Full Text via DOI: 10.1210/jc.2009-1102 PMID: 20089617
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2010Pdx-1 Regulation of the INGAP Promoter Involves Sequestration of NeuroD Into a Non-DNA-Binding Complex. PANCREAS. 39:64-70.Full Text via DOI: 10.1097/mpa.0b013e3181baa0cc PMID: 19770784
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2009A role for islet neogenesis in curing diabetes.. DIABETOLOGIA. 735-8.Full Text via DOI: 10.1007/s00125-009-1322-y PMID: 19271208
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2009The role of islet neogeneis-associated protein (INGAP) in pancreatic islet neogenesis.. CURRENT PROTEIN & PEPTIDE SCIENCE. 37-45.Full Text via DOI: 10.2174/138920309787315211 PMID: 19275671
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2008Transplantation and beyond. DRUG DEVELOPMENT RESEARCH. 69:165-176.Full Text via DOI: 10.1002/ddr.20242
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2008Pancreatic islet immunoreactivity to the Reg protein INGAP.. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 56:183-91.Full Text via DOI: 10.1369/jhc.7a7365.2007 PMID: 17998566
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2008The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas.. PANCREAS. 36:1-9.Full Text via DOI: 10.1097/mpa.0b013r318148c8e6 PMID: 18192873
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2007Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs.. PANCREAS. 34:103-11.Full Text via DOI: 10.1097/01.mpa.0000240609.56806.43 PMID: 17198191
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2006PDX-1 can repress stimulus-induced activation of the INGAP promoter. JOURNAL OF ENDOCRINOLOGY. 188:611-621.Full Text via DOI: 10.1677/joe.1.06108 PMID: 16522740
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2006Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin.. JOURNAL OF ENDOCRINOLOGY. 190:729-37.Full Text via DOI: 10.1677/joe.1.06698 PMID: 17003274
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2005Monocarboxylate transporter MCT1 is a target for immunosuppression. Nature Chemical Biology. 1:371-376.Full Text via DOI: 10.1038/nchembio744 PMID: 16370372
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2004A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice.. ANNALS OF SURGERY. 240:875-84.Full Text via DOI: 10.1097/01.sla.0000143270.99191.10 PMID: 15492571
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2004Advances in diabetes for the millennium: toward a cure for diabetes.. MedGenMed : Medscape general medicine. 12.PMID: 15647717
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2004Stimulation of pancreatic islet neogenesis: a possible treatment for type 1 and type 2 diabetes. Current Opinion in Endocrinology & Diabetes. 11:125-140.Full Text via DOI: 10.1097/01.med.0000125482.65536.0a
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2003Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites.. Biochimica et biophysica acta. 1638:83-9.Full Text via DOI: 10.1016/s0925-4439(03)00042-5 PMID: 12757938
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1998K21-antigen: a molecule shared by the microenvironments of the human thymus and germinal centers.. Developmental immunology. 41-52.Full Text via DOI: 10.1155/1998/29340 PMID: 9716904
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1998The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family.. European journal of immunology. 28:4071-83.Full Text via DOI: 10.1002/(sici)1521-4141(199812)28:12<4071::aid-immu4071>3.0.co;2-o PMID: 9862343
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1996Antigen receptor, structure and signaling in T cells. Lymphocyte Signalling: Mechanisms, Subversion and Manipulation. Ed. Harnett, M.
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1995Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.. European journal of immunology. 25:2961-6.Full Text via DOI: 10.1002/eji.1830251037 PMID: 7589098
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1995Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells. European journal of immunology. 25:3215-3221.Full Text via DOI: 10.1002/eji.1830251203 PMID: 8566003
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1994Cytokine receptor signal transduction. Bailliere's Clinical Infectious Diseases. Ed. Griffin, G E.
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1993Characterization of a novel high affinity human IL-7 receptor. Expression on T cells and association with IL-7 driven proliferation.. JOURNAL OF IMMUNOLOGY. 151:4753-63.PMID: 8409434
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1993Evidence that rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use.. Transplantation. 56:368-74.Full Text via DOI: 10.1097/00007890-199308000-00023 PMID: 7689258
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1993Inhibition of activation-induced changes in the structure of the T cell interleukin-7 receptor by cyclosporin A and FK506.. European journal of immunology. 23:85-9.Full Text via DOI: 10.1002/eji.1830230114 PMID: 7678231
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1992Activation induced changes in expression and structure of the IL-7 receptor on human T cells.. INTERNATIONAL IMMUNOLOGY. 4:277-82.Full Text via DOI: 10.1093/intimm/4.2.277 PMID: 1535786
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1991Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor. European journal of immunology. 21:1649-1656.Full Text via DOI: 10.1002/eji.1830210710 PMID: 1647956
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1991Interleukin 4 induces interleukin 6 production by endothelial cells: Synergy with interferon-γ. European journal of immunology. 21:97-101.Full Text via DOI: 10.1002/eji.1830210115 PMID: 1899386
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1988Biotinylated recombinant interleukin-2. Journal of Immunological Methods. 113:221-229.Full Text via DOI: 10.1016/0022-1759(88)90335-3 PMID: 3262688
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1988COMPARISON OF THE STRUCTURE OF THE MURINE INTERLEUKIN 2 (IL 2) RECEPTOR ON CYTOTOXIC AND HELPER T CELL LINES BY CHEMICAL CROSS-LINKING OF125I-LABELED IL 2. European journal of immunology. 18:1515-1519.Full Text via DOI: 10.1002/eji.1830181007
Contact
full name
- David A. Taylor-Fishwick
