Taylor-Fishwick, David A.

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overview

  • David Taylor-Fishwick received his BSc (Hons) in Toxicology and Pharmacology at University of London, England whilst researching Interleukin-2 and the mechanism of action of the immunosuppressant drug Cyclosporine in Basel, Switzerland. He earned a PhD in Immunology at the Kennedy Institute of Rheumatology, Charing Cross Hospital and Royal Postgraduate Medical School, London, England. This thesis work studied cytokine identification, cytokine mechanisms of action and characterized cytokine receptor structure along with study of immunosuppressant drugs. Dr. Taylor-Fishwick developed an interest in cell signaling and T cell activation at the Immune Cell Biology Program, NNMC, Bethesda, MD. Dr. Taylor-Fishwick joined AstraZeneca plc, Loughborough, England progressing drug discovery in areas of T-subset immune modulation and immunosuppression. In 2000, Dr. Taylor-Fishwick joined the Diabetes Institutes at EVMS progressing a novel biological therapeutic for islet regeneration lead by Dr. Aaron Vinik from discovery to human clinical trials. Having identified an important immune interface that impedes islet regeneration, Dr. Taylor-Fishwick has continued funded studies at EVMS. These are focused on inflammatory factors and new drug discovery approaches to block the negative actions of inflammation. He is Vice-Chair and Professor in the Department of Microbiology and Molecular Cell Biology and is actively involved in Graduate Bioscience education and pre-clerkship Medical education.

selected publications

research overview

  • Interests include (not limited to), immune modulation, T cell activation, inflammation, cell signaling, growth factors in disease and receptor/ligand interactions. Cell biology and assay development. Islet biology and cell regeneration. Diabetes and oxidative stress (NOX). Application of small molecule discovery and profiling mechanisms of action.



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preferred title

  • Professor and Vice Chair Microbiology and Molecular Cell Biology

full name

  • David A. Taylor-Fishwick, PhD

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