- I have completed extensive research on myosin, a motor protein that helps muscles move, and received grants from the NIH and the American Heart Association. I am investigating how cardiomyopathy mutations alter the ATPase enzyme mechanism and how different pharmacological agents affect the chemomechanical cycle. I am also interested in non-muscle myosins specifically myosinXIX that is a motor protein responsible for the transport of mitochondria in the cell.
Postdoctoral Fellowship, EVMS, Department of Physiological Sciences, Norfolk VA 2003-2006
PhD Eotvos University and National Institute of Oncology, Budapest, Hungary 2003
M.S. Eotvos University, Faculty of Sciences, Budapest, Hungary 1984
2015- Associate Professor, Eastern Virginia Medical School Department of Physiological Sciences
2009 - 2015 Assistant Professor, Eastern Virginia Medical School Department of Physiological Sciences
2006 - 2009 Research Assistant Professor, Eastern Virginia Medical School, Department of Physiological Sciences
2003 - 2006 Postdoctoral Fellow, Eastern Virginia Medical School, Department of Physiological Sciences
2001 - 2003 Research Associate, Eastern Virginia Medical School, Department of Microbiology and Molecular Cell Biology
1996 - 2000 Research Associate, University of Texas Southwestern Medical Center at Dallas, Hamon Center for Therapeutic Oncology
1990-1996 Research Assistant, University of Texas Medical Branch at Galveston, Texas
NIH/NHLBI RO1 (MultiPI grant/) Structural, Biochemical, and Mechanical Effects of Myosin Cardiomyopathy Mutations (PI: Eva Forgacs). 07/01/2016 - 04/30/2021
NIH/NIGMS R15: Myosin XIX and the Molecular Mechansim of Actin-based Mitochondrial Organization (Co-Investigator/EVMS PI). 08/11/2016 - 07/31/2020
NIH/NHLBI R56 Structure and Mechanism of Cardiomyopathy Myosin Mutants (PI: Eva Forgacs). 09/01/2014-08/31/2016
EVMS Bridge Grant (PI: Eva Forgacs). Structure and Mechanism of Cardiomyopathy Myosin Mutants ($22,320 direct cost)
American Heart Association Beginning Grant In Aid (PI: Eva Forgacs). The Impact of Cardiomyopathy Mutations on the Human β-Cardiac Myosin Motor Function. 07/01/2012-06/30/2014.
Jeffress Memorial Trust Award (PI: Eva Forgacs). Molecular Mechanism of Cardiomyopathies. 12/31/2011-06/30/2012
NIH/NIDCD RO3 (PI: Eva Forgacs). The Effect Of Deafness Associated Mutations on MyosinVIIA Function. 05/01/2008-4/30/12
NIH/NIDCD RO3 (PI: Eva Forgacs). The Effect Of Deafness Associated Mutations on MyosinVIIA Function. 07/17/2009 - 6/30/09
2019Human Beta-Cardiac Myosin Cardiomyopathy Mutations R712L and E497D Disrupt a Key Salt-Bridge in the Coupling Domain. BIOPHYSICAL JOURNAL. 264A-264A.
2018N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. STRUCTURE. 26:1604-+.
2018The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step. JOURNAL OF BIOLOGICAL CHEMISTRY. 293:819-829.
2017Biochemical and Mechanical Properties of the S532P and R712L Cardiomyopathy Myosin Mutants. BIOPHYSICAL JOURNAL. 556A-557A.
2017Kinetic Characterization of the Mitochondrial Transporter Human Myosin XIX. BIOPHYSICAL JOURNAL. 264A-264A.
2015Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity. JOURNAL OF MOLECULAR BIOLOGY. 427:3273-3284.
2015Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity. NATURE COMMUNICATIONS. 6.
2015Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine beta-Cardiac Myosin. BIOCHEMISTRY. 54:1963-1975.
2013Engineering of the Myosin Viia Nucleotide-Binding Pocket to Create Selective Sensitivity to N-6-Modified ADP Analogs. BIOPHYSICAL JOURNAL. 644A-644A.
2012The Shaker-1 Mouse Myosin VIIa has a Drastically Compromised ATP Hydrolysis Mechanism. BIOPHYSICAL JOURNAL. 569A-570A.
2011The Kinetic Mechanism of Mouse Myosin VIIA. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:8819-8828.
2010Influence of lever structure on myosin 5a walking. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107:2509-2514.
2010A Comparison of Mechanical Properties of Drosophila and Mouse Myosin 7a. BIOPHYSICAL JOURNAL. 725A-725A.
2010Mechanical and Kinetic Properties of a Myosin 5-SAH Chimera. BIOPHYSICAL JOURNAL. 563A-564A.
2010Mouse Myosinviia is a Monomeric, "slow" Motor with an Intermediate Duty Ratio. BIOPHYSICAL JOURNAL. 724A-725A.
2010Myosin 5A Walking Mechanism: The Structural Basis of Slow ADP Dissociatin from the Lead Head. BIOPHYSICAL JOURNAL. 229A-229A.
2009The SAH domain extends the functional length of the myosin lever. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:22193-22198.
2009Switch 1 Mutation S217A Converts Myosin V into a Low Duty Ratio Motor. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:2138-2149.
2008Direct observation of the mechanochemical coupling in myosin Va during processive movement. NATURE. 455:128-U99.
2008Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:766-773.
2007Mutational analysis of the myosinV active site. BIOPHYSICAL JOURNAL. 493A-493A.
2007The effect of IQ mutations upon the kinetics of ADP dissociation from ActomyosinV-HMM-ADP-Pi. BIOPHYSICAL JOURNAL. 637A-637A.
2006Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. BIOCHEMISTRY. 45:13035-13045.
- Associate Professor
- Eva Forgacs-Lonart, PhD
recognition and awards
Member of the Biophysical Society
Member of the American Heart Association
2006- Co-chair of Platform Session on Myosin and Myosin-Family Proteins. Biophysical Society Annual Meeting, Salt Lake City, Utah
2005-2007- Postdoctoral Fellowship, American Heart Association
2005- Travel Grant, International Biophysics Congress in Montpellier, France. National Academies and Biophysical Society