Nyalwidhe, Julius O.
- Associate Professor, Microbiology and Molecular Cell Biology
Contact Info
Publications
selected publications
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2020Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination. PROTEOMICS CLINICAL APPLICATIONS.Full Text via DOI: 10.1002/prca.202000012 PMID: 32614141
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2019Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264. DIABETES CARE. E85-E86.Full Text via DOI: 10.2337/dci19-0012 PMID: 31010952
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2019Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. DIABETES CARE. 42:258-264.Full Text via DOI: 10.2337/dc17-2625 PMID: 30530850
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2019Abnormalities in proinsulin processing in islets from individuals with longstanding T1D. TRANSLATIONAL RESEARCH. 213:90-99.Full Text via DOI: 10.1016/j.trsl.2019.08.001 PMID: 31442418
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2017Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes. JOURNAL OF THE ENDOCRINE SOCIETY. 1:1272-1286.Full Text via DOI: 10.1210/js.2017-00278 PMID: 29264452
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2016Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. NATURE COMMUNICATIONS. 7.Full Text via DOI: 10.1038/ncomms11906 PMID: 27350604
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2016Eosinophil Quantitated Urine Kinetic A novel assay for assessment of eosinophilic esophagitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 116:435-439.Full Text via DOI: 10.1016/j.anai.2016.02.011 PMID: 27017558
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2016Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma. PLOS ONE. 11.Full Text via DOI: 10.1371/journal.pone.0154074 PMID: 27128972
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2016Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. JOURNAL OF CLINICAL VIROLOGY. 77:21-28.Full Text via DOI: 10.1016/j.jcv.2016.01.015 PMID: 26875099
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2016A 1-Year-Old With Mycobacterium tuberculosis Endocarditis With Mass Spectrometry Analysis of Cardiac Vegetation Composition. JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY. 5:85-88.Full Text via DOI: 10.1093/jpids/piu087 PMID: 26908495
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2016Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes. BIOMED RESEARCH INTERNATIONAL.Full Text via DOI: 10.1155/2016/1785201 PMID: 27478826
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2015Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.
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2015Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0135663 PMID: 26302420
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2015Comparative Metabolomic and Lipidomic Analysis of Phenotype Stratified Prostate Cells. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0134206 PMID: 26244785
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2015Novel altered mitochondrial genes in prostate cancer progression. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-3045
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2015Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0132446 PMID: 26196285
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2015New potential role of serum apolipoprotein E mediated by its binding to clumping factor A during Staphylococcus aureus invasive infections to humans. JOURNAL OF MEDICAL MICROBIOLOGY. 64:335-343.Full Text via DOI: 10.1099/jmm.0.000010 PMID: 25878259
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2015Altered Glycosylation in Prostate Cancer. GLYCOSYLATION AND CANCER. 345-382.Full Text via DOI: 10.1016/bs.acr.2014.12.001 PMID: 25727153
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2015Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.Full Text via DOI: 10.18632/oncotarget.6193 PMID: 26497208
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2015Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort. EUROPEAN JOURNAL OF NEUROLOGY. 22:591-599.Full Text via DOI: 10.1111/ene.12534 PMID: 25104396
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2014Differential plectin isoform expression correlates with aggressive prostate cancer phenotypes. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-54
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2014Characterization of secreted proteins of 2-cell mouse embryos cultured in vitro to the blastocyst stage with and without protein supplementation. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 31:757-765.Full Text via DOI: 10.1007/s10815-014-0207-2 PMID: 24658922
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2013Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. PROTEOMICS CLINICAL APPLICATIONS. 7:677-689.Full Text via DOI: 10.1002/prca.201200134 PMID: 23775902
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2013Interlaboratory Study on Differential Analysis of Protein Glycosylation by Mass Spectrometry: The ABRF Glycoprotein Research Multi-Institutional Study 2012. MOLECULAR & CELLULAR PROTEOMICS. 12:2935-2951.Full Text via DOI: 10.1074/mcp.M113.030643 PMID: 23764502
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2013Variable Metastatic Potentials Correlate with Differential Plectin and Vimentin Expression in Syngeneic Androgen Independent Prostate Cancer Cells. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0065005 PMID: 23717685
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2013In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. PROTEOMICS. 13:1667-1671.Full Text via DOI: 10.1002/pmic.201200561 PMID: 23533145
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2013The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach. MOLECULAR HUMAN REPRODUCTION. 19:250-263.Full Text via DOI: 10.1093/molehr/gas063 PMID: 23247814
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2013Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.. Results in immunology. 114-21.Full Text via DOI: 10.1016/j.rinim.2013.10.004 PMID: 24600566
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2013Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG). Cell signalling and Trafficking. 1:1.Full Text via DOI: 10.7243/2054-1481-1-1
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2012Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 11:1870-1884.Full Text via DOI: 10.1074/mcp.M112.017889 PMID: 22986220
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2012Staphylococcus aureus surface protein SdrE binds the complement regulator factor H to evade the immune response. IMMUNOBIOLOGY. 1204-1204.Full Text via DOI: 10.1016/j.imbio.2012.08.216
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2012THE SEARCH FOR BIOMARKERS OF HUMAN EMBRYO DEVELOPMENTAL POTENTIAL IN IVF: A COMPREHENSIVE PROTEOMIC APPROACH.. FERTILITY AND STERILITY. S272-S272.
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2012Staphylococcus aureus Surface Protein SdrE Binds Complement Regulator Factor H as an Immune Evasion Tactic. PLOS ONE. 7.Full Text via DOI: 10.1371/journal.pone.0038407 PMID: 22675461
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2012Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization. MOLECULAR IMMUNOLOGY. 50:253-261.Full Text via DOI: 10.1016/j.molimm.2012.01.010 PMID: 22333221
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2012Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine. JOURNAL OF PROTEOME RESEARCH. 11:2386-2396.Full Text via DOI: 10.1021/pr2011236 PMID: 22339264
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2012Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus. JOURNAL OF TRANSLATIONAL MEDICINE. 10.Full Text via DOI: 10.1186/1479-5876-10-35 PMID: 22390383
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2011Protease inhibitors decrease IgG shedding from Staphylococcus aureus, increasing complement activation and phagocytosis efficiency. JOURNAL OF MEDICAL MICROBIOLOGY. 60:1415-1422.Full Text via DOI: 10.1099/jmm.0.027557-0 PMID: 21636671
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2011Hyperglycemic conditions inhibit C3-mediated host defenses against bacterial pathogens and change the tertiary structure of C3. MOLECULAR IMMUNOLOGY. 1695-1696.Full Text via DOI: 10.1016/j.molimm.2011.06.312
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2011Identification of Staphylococcus aureus surface protein SdrE as a complement factor H-binding molecule. MOLECULAR IMMUNOLOGY. 1695-1695.Full Text via DOI: 10.1016/j.molimm.2011.06.311
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2011On-tissue identification of insulin: In situ reduction coupled with mass spectrometry imaging. PROTEOMICS CLINICAL APPLICATIONS. 5:448-453.Full Text via DOI: 10.1002/prca.201000152 PMID: 21656913
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2011Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 10.Full Text via DOI: 10.1074/mcp.M110.007294 PMID: 21447706
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2011Enhancement in MALDI-TOF MS analysis of the low molecular weight human serum proteome. JOURNAL OF MASS SPECTROMETRY. 85-89.Full Text via DOI: 10.1002/jms.1864 PMID: 21190259
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2011High Serum Levels of DNMT1 and Distant Failure in Head and Neck Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S530-S530.
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2010Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein. MOLECULAR IMMUNOLOGY. 48:305-313.
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2010Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:33348-33357.Full Text via DOI: 10.1074/jbc.M110.149609 PMID: 20713355
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2010The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:32897-32905.Full Text via DOI: 10.1074/jbc.M110.146373 PMID: 20729195
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2010Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. MALARIA JOURNAL. 9.Full Text via DOI: 10.1186/1475-2875-9-189 PMID: 20591164
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2010In-Depth Proteomic Analyses of Direct Expressed Prostatic Secretions. JOURNAL OF PROTEOME RESEARCH. 9:2109-2116.Full Text via DOI: 10.1021/pr1001498 PMID: 20334419
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2010Comprehensive proteome profiling of the Fe(III)-reducing myxobacterium Anaeromyxobacter dehalogenans 2CP-C during growth with fumarate and ferric citrate. PROTEOMICS. 10:1673-1684.Full Text via DOI: 10.1002/pmic.200900687 PMID: 20162560
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2010THE IDENTIFICATION OF SERUM BIOMARKERS OF HIGH-LET RADIATION EXPOSURE AND BIOLOGICAL SEQUELAE. HEALTH PHYSICS. 98:196-203.Full Text via DOI: 10.1097/HP.0b013e3181acff7c PMID: 20065683
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2010Adjacent Slice Prostate Cancer Prediction to Inform MALDI Imaging Biomarker Analyses. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.844403
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2010Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein. MOLECULAR IMMUNOLOGY. 48:305-313.Full Text via DOI: 10.1016/j.molimm.2010.07.012 PMID: 20728940
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2010Prostate Cancer Region Prediction using MALDI Mass Spectra. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.844494
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2009Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue. CLINICAL CANCER RESEARCH. 15:5541-5551.Full Text via DOI: 10.1158/1078-0432.CCR-08-2892 PMID: 19690195
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2009Proteomic Expression Profiling and Identification of Serum Proteins Using Immobilized Trypsin Beads with MALDI-TOF/TOF. JOURNAL OF PROTEOME RESEARCH. 8:4182-4192.Full Text via DOI: 10.1021/pr800836c PMID: 19603828
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2009Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. JOURNAL OF PROTEOMICS. 72:907-917.Full Text via DOI: 10.1016/j.jprot.2009.01.007 PMID: 19457353
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2009Serum Proteomic Biomarker Discovery Reflective of Stage and Obesity in Breast Cancer Patients. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 208:970-978.Full Text via DOI: 10.1016/j.jamcollsurg.2008.12.024 PMID: 19476873
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2009Proteomic Profile as a Prognostic Factor of Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S402-S403.
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2007McArthur revisited: fluorescence microscopes for field diagnostics.. Trends in parasitology. 468-9.Full Text via DOI: 10.1016/j.pt.2007.08.003 PMID: 17826338
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2006A proteomic approach towards the analysis of salt tolerance in Rhizobium etli and Sinorhizobium meliloti strains.. Current microbiology. 52:333-9.Full Text via DOI: 10.1007/s00284-005-6472-7 PMID: 16604415
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2006Proteases and chaperones are the most abundant proteins in the parasitophorous vacuole of Plasmodium falciparum-infected erythrocytes.. PROTEOMICS. 6:1563-73.Full Text via DOI: 10.1002/pmic.200500379 PMID: 16470785
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2003A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes.. Molecular and biochemical parasitology. 132:35-45.Full Text via DOI: 10.1016/j.molbiopara.2003.08.003 PMID: 14563535
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2003Intracellular parasitism: cell biological adaptations of parasitic protozoa to a life inside cells.. Zoology (Jena, Germany). 106:341-8.Full Text via DOI: 10.1078/0944-2006-00127 PMID: 16351918
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2002A nonpermeant biotin derivative gains access to the parasitophorous vacuole in Plasmodium falciparum-infected erythrocytes permeabilized with streptolysin O.. The Journal of biological chemistry. 277:40005-11.Full Text via DOI: 10.1074/jbc.m207077200 PMID: 12186876
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1997Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 91:456-60.Full Text via DOI: 10.1016/s0035-9203(97)90284-4 PMID: 9373654
Contact
full name
- Julius O. Nyalwidhe
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research areas
- Allergy
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Chemistry
- Endocrinology & Metabolism
- Environmental Sciences & Ecology
- General & Internal Medicine
- Genetics & Heredity
- Immunology
- Infectious Diseases
- Medical Laboratory Technology
- Microbiology
- Neurosciences & Neurology
- Nuclear Science & Technology
- Obstetrics & Gynecology
- Oncology
- Parasitology
- Pediatrics
- Public, Environmental & Occupational Health
- Radiology, Nuclear Medicine & Medical Imaging
- Reproductive Biology
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Spectroscopy
- Surgery
- Tropical Medicine
- Virology
- Zoology