Nyalwidhe, Julius O.

Nyalwidhe, Julius O.
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Positions

Associate Professor, Microbiology and Molecular Cell Biology

Contact Info

nyalwijo@evms.edu

selected publications

2020

Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination. PROTEOMICS CLINICAL APPLICATIONS.
Full Text via DOI: 10.1002/prca.202000012 PMID: 32614141
2019

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264. DIABETES CARE. E85-E86.
Full Text via DOI: 10.2337/dci19-0012 PMID: 31010952
2019

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. DIABETES CARE. 42:258-264.
Full Text via DOI: 10.2337/dc17-2625 PMID: 30530850
2019

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D. TRANSLATIONAL RESEARCH. 213:90-99.
Full Text via DOI: 10.1016/j.trsl.2019.08.001 PMID: 31442418
2017

Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes. PLOS ONE. 12.
Full Text via DOI: 10.1371/journal.pone.0183908 PMID: 28877242
2017

Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes. JOURNAL OF THE ENDOCRINE SOCIETY. 1:1272-1286.
Full Text via DOI: 10.1210/js.2017-00278 PMID: 29264452
2016

Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. NATURE COMMUNICATIONS. 7.
Full Text via DOI: 10.1038/ncomms11906 PMID: 27350604
2016

Eosinophil Quantitated Urine Kinetic A novel assay for assessment of eosinophilic esophagitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 116:435-439.
Full Text via DOI: 10.1016/j.anai.2016.02.011 PMID: 27017558
2016

Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma. PLOS ONE. 11.
Full Text via DOI: 10.1371/journal.pone.0154074 PMID: 27128972
2016

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. JOURNAL OF CLINICAL VIROLOGY. 77:21-28.
Full Text via DOI: 10.1016/j.jcv.2016.01.015 PMID: 26875099
2016

A 1-Year-Old With Mycobacterium tuberculosis Endocarditis With Mass Spectrometry Analysis of Cardiac Vegetation Composition. JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY. 5:85-88.
Full Text via DOI: 10.1093/jpids/piu087 PMID: 26908495
2016

Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes. BIOMED RESEARCH INTERNATIONAL.
Full Text via DOI: 10.1155/2016/1785201 PMID: 27478826
2015

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.
2015

Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0135663 PMID: 26302420
2015

Comparative Metabolomic and Lipidomic Analysis of Phenotype Stratified Prostate Cells. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0134206 PMID: 26244785
2015

Novel altered mitochondrial genes in prostate cancer progression. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2015-3045
2015

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0132446 PMID: 26196285
2015

New potential role of serum apolipoprotein E mediated by its binding to clumping factor A during Staphylococcus aureus invasive infections to humans. JOURNAL OF MEDICAL MICROBIOLOGY. 64:335-343.
Full Text via DOI: 10.1099/jmm.0.000010 PMID: 25878259
2015

Altered Glycosylation in Prostate Cancer. GLYCOSYLATION AND CANCER. 345-382.
Full Text via DOI: 10.1016/bs.acr.2014.12.001 PMID: 25727153
2015

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.
Full Text via DOI: 10.18632/oncotarget.6193 PMID: 26497208
2015

Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort. EUROPEAN JOURNAL OF NEUROLOGY. 22:591-599.
Full Text via DOI: 10.1111/ene.12534 PMID: 25104396
2014

Differential plectin isoform expression correlates with aggressive prostate cancer phenotypes. CANCER RESEARCH.
Full Text via DOI: 10.1158/1538-7445.AM2014-54
2014

Characterization of secreted proteins of 2-cell mouse embryos cultured in vitro to the blastocyst stage with and without protein supplementation. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 31:757-765.
Full Text via DOI: 10.1007/s10815-014-0207-2 PMID: 24658922
2013

Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. PROTEOMICS CLINICAL APPLICATIONS. 7:677-689.
Full Text via DOI: 10.1002/prca.201200134 PMID: 23775902
2013

Interlaboratory Study on Differential Analysis of Protein Glycosylation by Mass Spectrometry: The ABRF Glycoprotein Research Multi-Institutional Study 2012. MOLECULAR & CELLULAR PROTEOMICS. 12:2935-2951.
Full Text via DOI: 10.1074/mcp.M113.030643 PMID: 23764502
2013

Variable Metastatic Potentials Correlate with Differential Plectin and Vimentin Expression in Syngeneic Androgen Independent Prostate Cancer Cells. PLOS ONE. 8.
Full Text via DOI: 10.1371/journal.pone.0065005 PMID: 23717685
2013

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. PROTEOMICS. 13:1667-1671.
Full Text via DOI: 10.1002/pmic.201200561 PMID: 23533145
2013

The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach. MOLECULAR HUMAN REPRODUCTION. 19:250-263.
Full Text via DOI: 10.1093/molehr/gas063 PMID: 23247814
2013

Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.. Results in immunology. 114-21.
Full Text via DOI: 10.1016/j.rinim.2013.10.004 PMID: 24600566
2013

Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG). Cell signalling and Trafficking. 1:1.
Full Text via DOI: 10.7243/2054-1481-1-1
2012

Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 11:1870-1884.
Full Text via DOI: 10.1074/mcp.M112.017889 PMID: 22986220
2012

Staphylococcus aureus surface protein SdrE binds the complement regulator factor H to evade the immune response. IMMUNOBIOLOGY. 1204-1204.
Full Text via DOI: 10.1016/j.imbio.2012.08.216
2012

THE SEARCH FOR BIOMARKERS OF HUMAN EMBRYO DEVELOPMENTAL POTENTIAL IN IVF: A COMPREHENSIVE PROTEOMIC APPROACH.. FERTILITY AND STERILITY. S272-S272.
2012

Staphylococcus aureus Surface Protein SdrE Binds Complement Regulator Factor H as an Immune Evasion Tactic. PLOS ONE. 7.
Full Text via DOI: 10.1371/journal.pone.0038407 PMID: 22675461
2012

Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization. MOLECULAR IMMUNOLOGY. 50:253-261.
Full Text via DOI: 10.1016/j.molimm.2012.01.010 PMID: 22333221
2012

Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine. JOURNAL OF PROTEOME RESEARCH. 11:2386-2396.
Full Text via DOI: 10.1021/pr2011236 PMID: 22339264
2012

Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus. JOURNAL OF TRANSLATIONAL MEDICINE. 10.
Full Text via DOI: 10.1186/1479-5876-10-35 PMID: 22390383
2011

Protease inhibitors decrease IgG shedding from Staphylococcus aureus, increasing complement activation and phagocytosis efficiency. JOURNAL OF MEDICAL MICROBIOLOGY. 60:1415-1422.
Full Text via DOI: 10.1099/jmm.0.027557-0 PMID: 21636671
2011

Hyperglycemic conditions inhibit C3-mediated host defenses against bacterial pathogens and change the tertiary structure of C3. MOLECULAR IMMUNOLOGY. 1695-1696.
Full Text via DOI: 10.1016/j.molimm.2011.06.312
2011

Identification of Staphylococcus aureus surface protein SdrE as a complement factor H-binding molecule. MOLECULAR IMMUNOLOGY. 1695-1695.
Full Text via DOI: 10.1016/j.molimm.2011.06.311
2011

On-tissue identification of insulin: In situ reduction coupled with mass spectrometry imaging. PROTEOMICS CLINICAL APPLICATIONS. 5:448-453.
Full Text via DOI: 10.1002/prca.201000152 PMID: 21656913
2011

Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 10.
Full Text via DOI: 10.1074/mcp.M110.007294 PMID: 21447706
2011

Enhancement in MALDI-TOF MS analysis of the low molecular weight human serum proteome. JOURNAL OF MASS SPECTROMETRY. 85-89.
Full Text via DOI: 10.1002/jms.1864 PMID: 21190259
2011

High Serum Levels of DNMT1 and Distant Failure in Head and Neck Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S530-S530.
2010

Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein. MOLECULAR IMMUNOLOGY. 48:305-313.
2010

Structural Characterization of Prostatic Glycopeptides using Triple Quadrupole Mass Spectrometry Approaches Coupled with Simglycan Analysis Software. GLYCOBIOLOGY. 1491-1491.
2010

Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:33348-33357.
Full Text via DOI: 10.1074/jbc.M110.149609 PMID: 20713355
2010

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:32897-32905.
Full Text via DOI: 10.1074/jbc.M110.146373 PMID: 20729195
2010

Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. MALARIA JOURNAL. 9.
Full Text via DOI: 10.1186/1475-2875-9-189 PMID: 20591164
2010

In-Depth Proteomic Analyses of Direct Expressed Prostatic Secretions. JOURNAL OF PROTEOME RESEARCH. 9:2109-2116.
Full Text via DOI: 10.1021/pr1001498 PMID: 20334419
2010

Comprehensive proteome profiling of the Fe(III)-reducing myxobacterium Anaeromyxobacter dehalogenans 2CP-C during growth with fumarate and ferric citrate. PROTEOMICS. 10:1673-1684.
Full Text via DOI: 10.1002/pmic.200900687 PMID: 20162560
2010

THE IDENTIFICATION OF SERUM BIOMARKERS OF HIGH-LET RADIATION EXPOSURE AND BIOLOGICAL SEQUELAE. HEALTH PHYSICS. 98:196-203.
Full Text via DOI: 10.1097/HP.0b013e3181acff7c PMID: 20065683
2010

Adjacent Slice Prostate Cancer Prediction to Inform MALDI Imaging Biomarker Analyses. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.
Full Text via DOI: 10.1117/12.844403
2010

Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein. MOLECULAR IMMUNOLOGY. 48:305-313.
Full Text via DOI: 10.1016/j.molimm.2010.07.012 PMID: 20728940
2010

Prostate Cancer Region Prediction using MALDI Mass Spectra. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.
Full Text via DOI: 10.1117/12.844494
2009

Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue. CLINICAL CANCER RESEARCH. 15:5541-5551.
Full Text via DOI: 10.1158/1078-0432.CCR-08-2892 PMID: 19690195
2009

Proteomic Expression Profiling and Identification of Serum Proteins Using Immobilized Trypsin Beads with MALDI-TOF/TOF. JOURNAL OF PROTEOME RESEARCH. 8:4182-4192.
Full Text via DOI: 10.1021/pr800836c PMID: 19603828
2009

Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. JOURNAL OF PROTEOMICS. 72:907-917.
Full Text via DOI: 10.1016/j.jprot.2009.01.007 PMID: 19457353
2009

Expressed prostatic secretions in urine and directly collected prostatic fluids as enriched sources of prostate cancer protein biomarkers. CANCER RESEARCH.
2009

Serum Proteomic Biomarker Discovery Reflective of Stage and Obesity in Breast Cancer Patients. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 208:970-978.
Full Text via DOI: 10.1016/j.jamcollsurg.2008.12.024 PMID: 19476873
2009

Proteomic Profile as a Prognostic Factor of Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S402-S403.
2007

McArthur revisited: fluorescence microscopes for field diagnostics.. Trends in parasitology. 468-9.
Full Text via DOI: 10.1016/j.pt.2007.08.003 PMID: 17826338
2006

A proteomic approach towards the analysis of salt tolerance in Rhizobium etli and Sinorhizobium meliloti strains.. Current microbiology. 52:333-9.
Full Text via DOI: 10.1007/s00284-005-6472-7 PMID: 16604415
2006

Proteases and chaperones are the most abundant proteins in the parasitophorous vacuole of Plasmodium falciparum-infected erythrocytes.. PROTEOMICS. 6:1563-73.
Full Text via DOI: 10.1002/pmic.200500379 PMID: 16470785
2003

A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes.. Molecular and biochemical parasitology. 132:35-45.
Full Text via DOI: 10.1016/j.molbiopara.2003.08.003 PMID: 14563535
2003

Intracellular parasitism: cell biological adaptations of parasitic protozoa to a life inside cells.. Zoology (Jena, Germany). 106:341-8.
Full Text via DOI: 10.1078/0944-2006-00127 PMID: 16351918
2002

A nonpermeant biotin derivative gains access to the parasitophorous vacuole in Plasmodium falciparum-infected erythrocytes permeabilized with streptolysin O.. The Journal of biological chemistry. 277:40005-11.
Full Text via DOI: 10.1074/jbc.m207077200 PMID: 12186876
1997

Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 91:456-60.
Full Text via DOI: 10.1016/s0035-9203(97)90284-4 PMID: 9373654

full name

Julius O. Nyalwidhe

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