Clark, Meredith R.

Clark, Meredith R.
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mclark@conrad.org

selected publications

2022

Drug-releasing vaginal rings for HIV/STI and pregnancy prevention: a review of recent advances and clinical applications. EXPERT OPINION ON DRUG DELIVERY.
Full Text via DOI: 10.1080/17425247.2022.2020242 PMID: 34958283
2020

Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women. NUTRIENTS. 12.
Full Text via DOI: 10.3390/nu12103176 PMID: 33080839
2020

Preferences and Acceptability of Vaginal Delivery Forms for HIV Prevention Among Women, Male Partners and Key Informants in South Africa and Zimbabwe: Qualitative Findings. AIDS AND BEHAVIOR.
Full Text via DOI: 10.1007/s10461-020-02949-4 PMID: 32588257
2020

Pharmacokinetics of a weekly transdermal delivery system of tenofovir alafenamide in hairless rats.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 582:119342.
Full Text via DOI: 10.1016/j.ijpharm.2020.119342 PMID: 32315746
2019

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV. PHARMACEUTICS. 11.
Full Text via DOI: 10.3390/pharmaceutics11040173 PMID: 30970630
2019

Efficacy is Not Everything: Eliciting Women's Preferences for a Vaginal HIV Prevention Product Using a Discrete-Choice Experiment. AIDS AND BEHAVIOR.
Full Text via DOI: 10.1007/s10461-019-02715-1 PMID: 31696371
2019

Topical Inserts: A Versatile Delivery Form for HIV Prevention. PHARMACEUTICS.
Full Text via DOI: 10.3390/pharmaceutics11080374 PMID: 31374941
2018

Testing Objective Markers of Placebo Vaginal Product Adherence in the Field. AIDS RESEARCH AND HUMAN RETROVIRUSES. 26-26.
2018

Using Photovoice to Understand the Experience and Realities of Female Sex Workers in the Context of HIV Self-testing in Blantyre, Malawi. AIDS RESEARCH AND HUMAN RETROVIRUSES. 158-158.
2018

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women. PLOS ONE. 13.
Full Text via DOI: 10.1371/journal.pone.0199778 PMID: 29953547
2018

Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant techniques. PLOS ONE. 13.
Full Text via DOI: 10.1371/journal.pone.0197906 PMID: 29799875
2018

Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies. CLINICAL AND TRANSLATIONAL MEDICINE. 7.
Full Text via DOI: 10.1186/s40169-018-0213-6 PMID: 30402770
2018

Re-assessing the Validity of the Opioid Risk Tool in a Tertiary Academic Pain Management Center Population. PAIN MEDICINE. 19:1382-1395.
Full Text via DOI: 10.1093/pm/pnx332 PMID: 29408996
2017

Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. BIOMATERIALS. 144:144-154.
Full Text via DOI: 10.1016/j.biomaterials.2017.08.029 PMID: 28829952
2017

Expanding the Domain of Drug Delivery for HIV Prevention: Exploration of the Transdermal Route. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS. 551-587.
Full Text via DOI: 10.1615/CritRevTherDrugCarrierSyst.2017020147 PMID: 29256837
2016

Can Infrared Spectroscopy (IR) Coupled with Chemometrics Be Used for Objective Measure of Adherence to Microbicide Products?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 94-94.
2016

Clinical Assessment of New Objective Measures of Adherence for Four Placebo Vaginal Dosage Platforms. AIDS RESEARCH AND HUMAN RETROVIRUSES. 95-95.
2016

Clinical Performance, Acceptability, and Optimization of Fast-dissolve Vaginal Inserts Designed for HIV-prevention: Results from Two Clinical Studies. AIDS RESEARCH AND HUMAN RETROVIRUSES. 53-53.
2016

Correlation of Residual Microbicide Levels with Objective Biomarker Analysis to Determine Adherence in a Large Phase III HIV Prevention Trial. AIDS RESEARCH AND HUMAN RETROVIRUSES. 387-387.
2016

Development and Proof-of-Concept Clinical Evaluation of a Freeze-dried Topical Microbicide Insert for On-demand HIV Prevention. AIDS RESEARCH AND HUMAN RETROVIRUSES. 69-69.
2016

Development of Long-acting Nanoparticle-based Formulations for Prolonged Intravaginal Delivery of Elvitegravir. AIDS RESEARCH AND HUMAN RETROVIRUSES. 228-228.
2016

Long-acting Intrauterine System Delivers Integrase Inhibitor Throughout the Reproductive Tract of Rabbits and Macaques. AIDS RESEARCH AND HUMAN RETROVIRUSES. 227-227.
2016

Pharmacokinetics/Pharmacodynamics of Tenofovir and Tenofovir Plus Levonorgestrel Vaginal Rings in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 389-389.
2016

The Role of Vitamin D on Genital Mucosal Immunity and Markers of HIV Susceptibility in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 320-320.
2016

Time of Addition Studies of Elvitegravir/TFV Prodrug Combinations Demonstrate Extended Window of Prophylactic Activity in Cell and Tissue Models. AIDS RESEARCH AND HUMAN RETROVIRUSES. 232-232.
2016

Multipurpose Prevention Approaches with Antiretroviral-Based Formulations. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 60:1141-1144.
Full Text via DOI: 10.1128/AAC.02468-15 PMID: 26596943
2014

Pharmacokinetic and Safety Analyses of Tenofovir and TenofovirEmtricitabine Vaginal Tablets in Pigtailed Macaques. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 58:2665-2674.
Full Text via DOI: 10.1128/AAC.02336-13 PMID: 24566178
2014

Engineering a Segmented Dual-Reservoir Polyurethane Intravaginal Ring for Simultaneous Prevention of HIV Transmission and Unwanted Pregnancy. PLOS ONE. 9.
Full Text via DOI: 10.1371/journal.pone.0088509 PMID: 24599325
2014

Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention.
Full Text via DOI: 10.3390/pharmaceutics6040616 PMID: 25494201
2013

Multipurpose prevention technologies: Products in development. ANTIVIRAL RESEARCH. S39-S47.
Full Text via DOI: 10.1016/j.antiviral.2013.09.030 PMID: 24188708
2013

Investigating the feasibility of temperature-controlled accelerated drug release testing for an intravaginal ring. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 85:966-973.
Full Text via DOI: 10.1016/j.ejpb.2013.06.004 PMID: 23791685
2013

PRELIMINARY PHARMACOKINETIC, PHARMACODYNAMICS, AND SAFETY ANALYSES OF VAGINAL TENOFOVIR TABLETS IN PIGTAIL MACAQUES. JOURNAL OF MEDICAL PRIMATOLOGY. 280-280.
2013

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies. INTERNATIONAL JOURNAL OF WOMENS HEALTH. 695-708.
Full Text via DOI: 10.2147/IJWH.S34030 PMID: 24174884
2013

Preformulation and development of a once-daily sustained-release tenofovir vaginal tablet tablet containing a single excipient. JOURNAL OF PHARMACEUTICAL SCIENCES. 102:1859-1868.
Full Text via DOI: 10.1002/jps.23528 PMID: 23568749
2013

Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies. ANTIVIRAL RESEARCH. S1-S2.
Full Text via DOI: 10.1016/j.antiviral.2013.09.024 PMID: 24188704
2012

A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 56:6272-6283.
Full Text via DOI: 10.1128/AAC.01431-12 PMID: 23006751
2012

Pharmacokinetics and Topical Vaginal Effects of Two Tenofovir Gels in Rabbits. AIDS RESEARCH AND HUMAN RETROVIRUSES. 28:1458-1466.
Full Text via DOI: 10.1089/aid.2011.0328 PMID: 22394281
2012

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir. JOURNAL OF CONTROLLED RELEASE. 163:240-248.
Full Text via DOI: 10.1016/j.jconrel.2012.08.033 PMID: 22981701
2012

Development of a new intravaginal ring technology for the extended delivery of the microbicide tenofovir with and without the contraceptive levonorgestrel. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 27-27.
2012

An intravaginal ring for the simultaneous delivery of multiple drugs. JOURNAL OF PHARMACEUTICAL SCIENCES. 101:2833-2843.
Full Text via DOI: 10.1002/jps.23208 PMID: 22619076
2012

Characterization of UC781-Tenofovir Combination Gel Products for HIV-1 Infection Prevention in an Ex Vivo Ectocervical Model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 56:3058-3066.
Full Text via DOI: 10.1128/AAC.06284-11 PMID: 22430977
2012

Design of Tenofovir-UC781 Combination Microbicide Vaginal Gels. JOURNAL OF PHARMACEUTICAL SCIENCES. 101:1852-1864.
Full Text via DOI: 10.1002/jps.23089 PMID: 22359356
2012

Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 100B:891-895.
Full Text via DOI: 10.1002/jbm.b.31919 PMID: 22438332
2012

A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781. JOURNAL OF PHARMACEUTICAL SCIENCES. 101:576-587.
Full Text via DOI: 10.1002/jps.22781 PMID: 21976110
2012

Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 56:875-882.
Full Text via DOI: 10.1128/AAC.05662-11 PMID: 22123689
2012

Development of a UC781 releasing polyethylene vinyl acetate vaginal ring. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 2:489-497.
Full Text via DOI: 10.1007/s13346-012-0101-3 PMID: 25787327
2011

Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: a comparison of polymer matrices. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 1:238-246.
Full Text via DOI: 10.1007/s13346-011-0032-4 PMID: 25788242
2011

Preclinical evaluation of UC781 microbicide vaginal drug delivery. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 1:175-182.
Full Text via DOI: 10.1007/s13346-011-0019-1 PMID: 25788115
2011

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 413:10-18.
Full Text via DOI: 10.1016/j.ijpharm.2011.04.004 PMID: 21511017
2011

Ethylene vinyl acetate intravaginal rings for the simultaneous delivery of the antiretroviral UC781 and contraceptive levonorgestrel. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 1:247-255.
Full Text via DOI: 10.1007/s13346-011-0031-5 PMID: 25788243
2011

Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.. Infectious diseases in obstetrics and gynecology. 1-10.
Full Text via DOI: 10.1155/2011/429403 PMID: 21836811
2010

Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers. ANTIVIRAL RESEARCH. S10-S18.
Full Text via DOI: 10.1016/j.antiviral.2010.09.018 PMID: 21109063
2010

Design of a Semisolid Vaginal Microbicide Gel by Relating Composition to Properties and Performance. PHARMACEUTICAL RESEARCH. 27:2478-2491.
Full Text via DOI: 10.1007/s11095-010-0244-1 PMID: 20842411
2009

In situcrosslinked hydrogels formed using Cu(I)-free Huisgen cycloaddition reaction. Polymer International. 58:1190-1195.
Full Text via DOI: 10.1002/pi.2650
2009

Modulation of Viscoelasticity and HIV Transport as a Function of pH in a Reversibly Crosslinked Hydrogel.. Advanced functional materials. 19:2969-2977.
Full Text via DOI: 10.1002/adfm.200900757 PMID: 23101003
2008

Chemorheology of phenylboronate-salicylhydroxamate crosslinked hydrogel networks with a sulfonated polymer backbone.. Macromolecules. 41:8832-8840.
Full Text via DOI: 10.1021/ma8012674 PMID: 23132956
2007

Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks. Advanced Materials. 19:2503-2507.
Full Text via DOI: 10.1002/adma.200602649
2007

Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles.. JOURNAL OF PHARMACEUTICAL SCIENCES. 96:670-81.
Full Text via DOI: 10.1002/jps.20752 PMID: 17154368
2002

Disulfide cross-linked hyaluronan hydrogels.. Biomacromolecules. 3:1304-11.
Full Text via DOI: 10.1021/bm025603c PMID: 12425669

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Meredith R. Clark

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