Publications
selected publications
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2021Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner. LIFE-BASEL. 11.Full Text via DOI: 10.3390/life11101098 PMID: 34685469
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2021Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO REPORTS.Full Text via DOI: 10.15252/embr.202051978 PMID: 34232545
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2021Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection. FRONTIERS IN IMMUNOLOGY. 12.Full Text via DOI: 10.3389/fimmu.2021.672415 PMID: 34093573
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2021Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases. CELLS.Full Text via DOI: 10.3390/cells10040890 PMID: 33919664
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2021Comparison of predictors for terminal disease progression in simian immunodeficiency virus/simian-HIV-infected rhesus macaques. AIDS. 35:1021-1029.Full Text via DOI: 10.1097/qad.0000000000002874
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2021Stress-Induced Accumulation of HnRNP K into Stress Granules. Journal of Cancer Science and Clinical Therapeutics. 05.Full Text via DOI: 10.26502/jcsct.5079129
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2020Clinical and Immunological Metrics During Pediatric Rhesus Macaque Development. FRONTIERS IN PEDIATRICS. 8.Full Text via DOI: 10.3389/fped.2020.00388 PMID: 32766187
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2020Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects.. International neurourology journal. 24:29-40.Full Text via DOI: 10.5213/inj.1938186.093 PMID: 32252184
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2019Overexpression and activation of colony-stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIV. BRAIN PATHOLOGY. 29:826-836.Full Text via DOI: 10.1111/bpa.12731 PMID: 31033097
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2019HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood-brain barrier integrity. JOURNAL OF NEUROVIROLOGY. 25:560-577.Full Text via DOI: 10.1007/s13365-019-00757-8 PMID: 31102185
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2019Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis. JOURNAL OF NEUROVIROLOGY. 25:578-588.Full Text via DOI: 10.1007/s13365-019-00755-w PMID: 31119711
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2019Opiates and HIV-1 perturb the cellular/regional biodistribution of antiretrovirals in the brain by disrupting the blood-brain barrier and efflux transporter function. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 334-334.
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2019Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques. JOURNAL OF IMMUNOLOGY. 202:2682-2689.Full Text via DOI: 10.4049/jimmunol.1801457 PMID: 30926643
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2019Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection. JOURNAL OF NEUROINFLAMMATION. 16.Full Text via DOI: 10.1186/s12974-019-1463-y PMID: 30981282
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2019Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 14:110-119.Full Text via DOI: 10.1007/s11481-018-9809-2 PMID: 30194646
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2019Untitled Reply. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 7-8.Full Text via DOI: 10.1007/s11481-018-09828-9 PMID: 30506435
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2019Perivascular macrophages in the neonatal macaque brain undergo massive necroptosis after simian immunodeficiency virus infection. BRAIN PATHOLOGY.Full Text via DOI: 10.1111/bpa.12808 PMID: 31834964
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2018Distribution of long-lived and short-lived macrophages in the intestinal tract of SIV-infected rhesus macaques. JOURNAL OF MEDICAL PRIMATOLOGY. 348-348.
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2018Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. JOURNAL OF IMMUNOLOGY. 200:4059-4067.Full Text via DOI: 10.4049/jimmunol.1800207 PMID: 29728510
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2018Overexpression and Activation of Colony-Stimulating Factor 1 Receptor in the SIV/Macaque Model of HIV Infection and NeuroAIDS. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.
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2018Overexpression and Activation of Colony-Stimulating Factor 1 Receptor in the SIV/Macaque Model of HIV Infection and NeuroAIDS. JOURNAL OF NEUROVIROLOGY. S38-S38.
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2017Differences between pediatric and adult rhesus macaques in CNS myeloid cell populations during SIV infection. JOURNAL OF MEDICAL PRIMATOLOGY. 200-200.
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2017Effects of CD8+lymphocyte depletion on the size of SIV reservoir in the brain. JOURNAL OF MEDICAL PRIMATOLOGY. 200-200.
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2017Evidence that long-lived macrophages are an important SIV reservoir in the rhesus macaque model of AIDS. JOURNAL OF MEDICAL PRIMATOLOGY. 165-165.
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2017Expression and phosphorylation of SAMHD1 increases with viral loads in the brains of SIV-infected rhesus macaques. JOURNAL OF MEDICAL PRIMATOLOGY. 164-164.
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2017Lower rate of SIV-encephalitis (SIVE) in pediatric compared to adult rhesus macaques with SIV infection. JOURNAL OF MEDICAL PRIMATOLOGY. 205-205.
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2017HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice. NEUROSCIENCE LETTERS. 640:136-143.Full Text via DOI: 10.1016/j.neulet.2016.12.073 PMID: 28057474
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2017Correction for Sugimoto et al., “Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques”. JOURNAL OF VIROLOGY.Full Text via DOI: 10.1128/jvi.01346-17 PMID: 29079716
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2017Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques.. JOURNAL OF VIROLOGY.Full Text via DOI: 10.1128/jvi.00379-17 PMID: 28566378
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2016Development of real-time PCR for quantitation of simian immunodeficiency virus 2-LTR circles. JOURNAL OF MEDICAL PRIMATOLOGY. 45:215-221.Full Text via DOI: 10.1111/jmp.12244 PMID: 27646719
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2016HIV-1 Tat causes regional differences in phagocytosis by perivascular macrophages and microglia and causes disruption of the blood-brain barrier. JOURNAL OF NEUROVIROLOGY. S42-S43.
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2016Phosphorylation of SAMHD1 in Brain Macrophages Increases with Viral Loads in the Brains of SIV-Infected Rhesus Macaques. JOURNAL OF NEUROVIROLOGY. S44-S44.
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2016Proliferation of Perivascular Macrophages Contributes to the Development of Encephalitic Lesions in HIV-Infected Humans and in SIV-Infected Macaques. SCIENTIFIC REPORTS. 6.Full Text via DOI: 10.1038/srep32900 PMID: 27610547
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2015Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus-Infected Rhesus Macaques. JOURNAL OF IMMUNOLOGY. 195:4884-4891.Full Text via DOI: 10.4049/jimmunol.1501194 PMID: 26432896
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2015COMPARATIVE ANALYSIS OF MACROPHAGE POPULATIONS AND THEIR CONTRIBUTIONS TO PULMONARY PATHOGENESIS IN YOUNG AND AGED SIV-INFECTED RHESUS MACAQUES. JOURNAL OF MEDICAL PRIMATOLOGY. 327-328.
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2015Editorial: Identification of in vivo markers for human polarized macrophages: a need that's finally met. JOURNAL OF LEUKOCYTE BIOLOGY. 449-450.Full Text via DOI: 10.1189/jlb.1CE0615-233RR PMID: 26429776
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2015IDENTIFICATION OF BIOMARKERS FOR MACROPHAGE DAMAGE IN SIV-INFECTED RHESUS MACAQUES. JOURNAL OF MEDICAL PRIMATOLOGY. 328-328.
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2015INCREASED EXPRESSION OF CD169 ON BLOOD MONOCYTES AND ITS CORRELATION WITH DISEASE STATUS IN MACAQUE MODELS OF HIV INFECTION AND AIDS. JOURNAL OF MEDICAL PRIMATOLOGY. 329-329.
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2015Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development. JOURNAL OF IMMUNOLOGY. 195:1774-1781.Full Text via DOI: 10.4049/jimmunol.1500522 PMID: 26179903
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2015Increased Expression of CD169 on Blood Monocytes and Its Regulation by Virus and CD8 T Cells in Macaque Models of HIV Infection and AIDS. AIDS RESEARCH AND HUMAN RETROVIRUSES. 31:696-706.Full Text via DOI: 10.1089/aid.2015.0003 PMID: 25891017
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2015Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques. JOURNAL OF LEUKOCYTE BIOLOGY. 97:1147-1153.Full Text via DOI: 10.1189/jlb.4A0914-441R PMID: 25780057
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2015
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2015A Draft Map of Rhesus Monkey Tissue Proteome for Biomedical Research. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0126243 PMID: 25974132
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2014Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 9:716-726.Full Text via DOI: 10.1007/s11481-014-9564-y PMID: 25146376
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2014HIGH MONOCYTE TURNOVER IS ASSOCIATED WITH HIGH SIV DNA, BUT NOT RNA, LEVELS IN THE BRAIN OF SIV-INFECTED RHESUS MACAQUES. JOURNAL OF MEDICAL PRIMATOLOGY. 412-413.
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2014SIV INFECTION OF INTERSTITIAL MACROPHAGES IN THE LUNG: EVIDENCE OF AN OVERLOOKED ROLE FOR MACROPHAGES IN AIDS PATHOGENESIS. JOURNAL OF MEDICAL PRIMATOLOGY. 379-379.
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2014SIV INFECTION OF LUNG MACROPHAGES CONTRIBUTES TO TISSUE DAMAGE AND INFLAMMATORY RESPONSES IN SIV-INFECTED RHESUS MACAQUES. JOURNAL OF MEDICAL PRIMATOLOGY. 407-407.
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2014Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis. JOURNAL OF NEUROIMMUNOLOGY. 267:50-60.Full Text via DOI: 10.1016/j.jneuroim.2013.12.002 PMID: 24369299
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2013MACROPHAGE PROLIFERATION IN HIV/SIV ENCEPHALITIS: A POSSIBLE MECHANISM FOR THE HIV LATENT RESERVOIR PERSISTENCE IN THE BRAIN. JOURNAL OF MEDICAL PRIMATOLOGY. 260-260.
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2013Outer membrane vesicles from pathogenic bacteria initiate an inflammatory response in human endothelial cells. JOURNAL OF SURGICAL RESEARCH. 184:458-466.Full Text via DOI: 10.1016/j.jss.2013.05.035 PMID: 23800440
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2012Development and Investigation of Flexible Polymer Neural Probe for Chronic Neural Recording. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.917481
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2011CHARACTERIZATION OF MYELOID LINEAGE CELLS IN TISSUE AND IMPACT OF MONOCYTE/MACROPHAGE TURNOVER ON PROGRESSION TO AIDS. JOURNAL OF MEDICAL PRIMATOLOGY. 259-259.
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2011MAC387+ MACROPHAGES: A THIRD MACROPHAGE POPULATION IN SIV ENCEPHALITIC LESIONS. JOURNAL OF MEDICAL PRIMATOLOGY. 257-257.
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2011Alterations in brain metabolism during the first year of HIV infection. JOURNAL OF NEUROVIROLOGY. 17:220-229.Full Text via DOI: 10.1007/s13365-011-0030-9 PMID: 21494901
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2011Recently Infiltrating MAC387(+) Monocytes/Macrophages A Third Macrophage Population Involved in SIV and HIV Encephalitic Lesion Formation. AMERICAN JOURNAL OF PATHOLOGY. 178:2121-2135.Full Text via DOI: 10.1016/j.ajpath.2011.01.023 PMID: 21514427
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2011Electrochemical Investigation of Nano-Electrodes for Biomedical Sensing Applications in the Brain. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.880567
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2011CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain.. JOURNAL OF MEDICAL PRIMATOLOGY. 40:300-9.Full Text via DOI: 10.1111/j.1600-0684.2011.00475.x PMID: 21463330
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2010Alterations in Brain Metabolism during the First Year of HIV-Infection. JOURNAL OF NEUROVIROLOGY. 49-49.
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2010Non productively infected MAC387+macrophages are a third population of macrophages involved in formation of Sly encephalitic lesions. JOURNAL OF NEUROVIROLOGY. 82-83.
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2010Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. JOURNAL OF NEUROIMMUNOLOGY. 226:81-92.Full Text via DOI: 10.1016/j.jneuroim.2010.05.034 PMID: 20599280
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2010Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage. JOURNAL OF LEUKOCYTE BIOLOGY. 87:557-567.Full Text via DOI: 10.1189/jlb.0209082 PMID: 19843579
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2009SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1. JOURNAL OF GENERAL VIROLOGY. 90:2005-2014.Full Text via DOI: 10.1099/vir.0.011072-0 PMID: 19420158
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2009Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.. NEUROLOGY. 72:1465-72.Full Text via DOI: 10.1212/wnl.0b013e3181a2e90a PMID: 19398702
Research
research overview
- Dr. Woong-Ki Kim obtained his Ph.D. degree from Rutgers - New Jersey Institute of Technology, where he studied neuropeptide regulation of microglia and astrocyte activation in spinal cord injury and herpes simplex virus 1 infection. Dr. Kim completed his post-doctoral training at Harvard Medical School and Beth Israel Deaconess Medical, studying viral immunology and virus-induced neuropathogenesis with focus on HIV and JC virus. Upon his tenure-track faculty appointment, Dr. Kim moved to Eastern Virginia Medical School in Norfolk, Virginia, where he has worked his way up to his current position of full professor. He has continued to study HIV pathogenesis with focus on macrophage biology, using both humans and nonhuman primates. Previously his research was very observational, mainly characterizing human and rhesus monocytes and tissue macrophages in detail. Over the past 5 years, turning into more mechanistic and translational type of research, his research program put more efforts in finding new macrophage targets and exploring existing compounds/drugs for their efficacy targeting specific macrophages and monocytes for the treatment of HIV brain infection. His other research currently focuses on 1) targeted drug delivery to CNS for the treatment of HIV-associated neurocognitive disorders, on 2) effects of opioid drug abuse on the HIV brain infection and neuropathogenesis, and on 3) mechanisms underlying HIV progressive encephalopathy in perinatally infected infants and children focusing on differences of neonatal versus adult brain myeloid cells.
Contact
preferred title
- No Longer at EVMS
full name
- Woong-Ki Kim, PhD