Duffy, Diane M.

Diane M. Duffy
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Positions

Professor, Physiological Sciences

Contact Info

duffydm@evms.edu

selected publications

2020

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation.
Full Text via DOI: 10.1016/j.celrep.2020.03.060 PMID: 32294429
2019

Ovulation: Parallels With Inflammatory Processes. ENDOCRINE REVIEWS. 369-416.
Full Text via DOI: 10.1210/er.2018-00075 PMID: 30496379
2019

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates. FRONTIERS IN ENDOCRINOLOGY. 10.
Full Text via DOI: 10.3389/fendo.2019.00727 PMID: 31787928
2018

Ovulatory Induction of SCG2 in Human, Nonhuman Primate, and Rodent Granulosa Cells Stimulates Ovarian Angiogenesis. ENDOCRINOLOGY. 159:2447-2458.
Full Text via DOI: 10.1210/en.2018-00020 PMID: 29648638
2018

Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles. ENDOCRINOLOGY. 159:710-722.
Full Text via DOI: 10.1210/en.2017-00739 PMID: 29095972
2017

Vascular endothelial growth factors C and D may promote angiogenesis in the primate ovulatory follicle. BIOLOGY OF REPRODUCTION. 96:389-400.
Full Text via DOI: 10.1095/biolreprod.116.144733 PMID: 28203718
2016

Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal. BIOLOGY OF REPRODUCTION.
Full Text via DOI: 10.1095/biolreprod.116.140574 PMID: 27307073
2016

Prostaglandin E2 and vascular endothelial growth factor A mediate angiogenesis of human ovarian follicular endothelial cells. HUMAN REPRODUCTION. 31:436-444.
Full Text via DOI: 10.1093/humrep/dev320 PMID: 26740577
2015

Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway. HUMAN REPRODUCTION UPDATE. 21:652-670.
Full Text via DOI: 10.1093/humupd/dmv026 PMID: 26025453
2015

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats. PLOS ONE. 10.
Full Text via DOI: 10.1371/journal.pone.0132446 PMID: 26196285
2015

Estrogen promotes luteolysis by redistributing prostaglandin F2 alpha receptors within primate luteal cells. REPRODUCTION. 149:453-464.
Full Text via DOI: 10.1530/REP-14-0412 PMID: 25687410
2015

Angiogenesis in the Primate Ovulatory Follicle Is Stimulated by Luteinizing Hormone via Prostaglandin E2. BIOLOGY OF REPRODUCTION. 92.
Full Text via DOI: 10.1095/biolreprod.114.123711 PMID: 25376231
2014

Ovarian Membrane-Type Matrix Metalloproteinases: Induction of MMP14 and MMP16 During the Periovulatory Period in the Rat, Macaque, and Human. BIOLOGY OF REPRODUCTION. 91.
Full Text via DOI: 10.1095/biolreprod.113.115717 PMID: 24920038
2014

Signaling Through FSH Receptors on Human Umbilical Vein Endothelial Cells Promotes Angiogenesis. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99:E813-E820.
Full Text via DOI: 10.1210/jc.2013-3186 PMID: 24527712
2014

Prostaglandin E2 (EP) Receptors Mediate PGE2-Specific Events in Ovulation and Luteinization Within Primate Ovarian Follicles. ENDOCRINOLOGY. 155:1466-1475.
Full Text via DOI: 10.1210/en.2013-2096 PMID: 24506073
2013

EP3 receptor isoforms are differentially expressed in subpopulations of primate granulosa cells and couple to unique G-proteins. REPRODUCTION. 146:625-635.
Full Text via DOI: 10.1530/REP-13-0274 PMID: 24062570
2013

The COX-2 inhibitor meloxicam prevents pregnancy when administered as an emergency contraceptive to nonhuman primates. CONTRACEPTION. 88:744-748.
Full Text via DOI: 10.1016/j.contraception.2013.09.006 PMID: 24120248
2013

The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys. CONTRACEPTION. 87:813-823.
Full Text via DOI: 10.1016/j.contraception.2012.09.032 PMID: 23121824
2011

Prostaglandin E2 Receptors Are Differentially Expressed in Subpopulations of Granulosa Cells from Primate Periovulatory Follicles. BIOLOGY OF REPRODUCTION. 85:916-923.
Full Text via DOI: 10.1095/biolreprod.111.091306 PMID: 21753194
2011

THYROID STIMULATING HORMONE (TSH) RECEPTOR ON GRANULOSA CELLS. FERTILITY AND STERILITY. S118-S118.
2011

Prostaglandin F2alpha Receptors (FP) in Human Granulosa-Lutein Cells: Acquisition of Function During Transition from Granulosa to Luteal Cell Phenotype. BIOLOGY OF REPRODUCTION.
2011

The Role of the PGE2 Receptor EP3 in Luteinization and Vascularization of the Primate Ovulatory Follicle. BIOLOGY OF REPRODUCTION.
2011

Maturation and fertilization of nonhuman primate oocytes are compromised by oral administration of a cyclooxygenase-2 inhibitor. FERTILITY AND STERILITY. 95:1256-1260.
Full Text via DOI: 10.1016/j.fertnstert.2010.12.048 PMID: 21236424
2011

Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 333:119-126.
Full Text via DOI: 10.1016/j.mce.2010.12.016 PMID: 21167905
2010

Mammalian oocytes are targets for prostaglandin E2 (PGE2) action. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 8.
Full Text via DOI: 10.1186/1477-7827-8-131 PMID: 21040553
2010

Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception. HUMAN REPRODUCTION. 25:360-367.
Full Text via DOI: 10.1093/humrep/dep424 PMID: 19965877
2010

PGE2 Receptors in Subpopulations of Primate Granulosa Cells: Differential Expression During the Periovulatory Interval.. BIOLOGY OF REPRODUCTION. 185-186.
2009

Prostaglandin E2 Acts via Multiple Receptors to Regulate Plasminogen-Dependent Proteolysis in the Primate Periovulatory Follicle. ENDOCRINOLOGY. 150:435-444.
Full Text via DOI: 10.1210/en.2008-0591 PMID: 18818294
2008

Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle. REPRODUCTION. 136:53-63.
Full Text via DOI: 10.1530/REP-07-0514 PMID: 18390687
2007

Molecular control of ovulation and luteinization in the primate follicle. FRONTIERS IN BIOSCIENCE. 12:297-307.
Full Text via DOI: 10.2741/2065 PMID: 17127300
2007

The plasminogen activator system is regulated by prostaglandins in the primate periovulatory follicle.. BIOLOGY OF REPRODUCTION. 188-188.
2006

Primate granulosa cell response via prostaglandin E2 receptors increases late in the periovulatory interval. BIOLOGY OF REPRODUCTION. 75:868-876.
Full Text via DOI: 10.1095/biolreprod.106.053769 PMID: 16943366
2006

Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium. FERTILITY AND STERILITY. 86:1088-1096.
Full Text via DOI: 10.1016/j.fertnstert.2006.03.022 PMID: 16962117
2006

Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 4.
Full Text via DOI: 10.1186/1477-7827-4-14 PMID: 16595009
2005

An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 90:5858-5865.
Full Text via DOI: 10.1210/jc.2005-0980 PMID: 15972573
2005

Adipose differentiation-related protein: A gonadotropin- and prostaglandin-regulated protein in primate periovulatory follicles. BIOLOGY OF REPRODUCTION. 72:1305-1314.
2005

Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle. HUMAN REPRODUCTION. 20:1485-1492.
Full Text via DOI: 10.1093/humrep/deh784 PMID: 15774546
2005

Prostaglandin dehydrogenase and prostaglandin levels in periovulatory follicles: Implications for control of primate ovulation by prostaglandin E2. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 90:1021-1027.
Full Text via DOI: 10.1210/jc.2004-1229 PMID: 15522934
2005

Monkey granulosa cell responsiveness to prostaglandin E-2 (PGE(2)) increases late in the periovulatory interval: A possible role for the PGE(2) receptor EP1 in primate ovulation.. BIOLOGY OF REPRODUCTION. 96-97.
2003

Growth differentiation factor-9 is expressed by the primate follicle throughout the periovulatory interval.. BIOLOGY OF REPRODUCTION. 69:725-32.
Full Text via DOI: 10.1095/biolreprod.103.015891 PMID: 12700191
2003

Luteinizing hormone acts directly at granulosa cells to stimulate periovulatory processes: modulation of luteinizing hormone effects by prostaglandins.. ENDOCRINE. 22:249-56.
Full Text via DOI: 10.1385/endo:22:3:249 PMID: 14709798
2002

Ca2+-activated, large conductance K+ channel in the ovary: identification, characterization, and functional involvement in steroidogenesis.. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 87:5566-74.
Full Text via DOI: 10.1210/jc.2002-020841 PMID: 12466354
2002

Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys.. HUMAN REPRODUCTION. 17:2825-31.
Full Text via DOI: 10.1093/humrep/17.11.2825 PMID: 12407033
2001

The ovulatory gonadotrophin surge stimulates cyclooxygenase expression and prostaglandin production by the monkey follicle.. Molecular human reproduction. 7:731-9.
Full Text via DOI: 10.1093/molehr/7.8.731 PMID: 11470860

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Diane M. Duffy

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