White, Howard D.
Contact Info
Publications
selected publications
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2019Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict?. JOURNAL OF GENERAL PHYSIOLOGY. 628-634.Full Text via DOI: 10.1085/jgp.201812198 PMID: 30824574
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2019
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2019A cryo-EM grid preparation device for time-resolved structural studies. IUCRJ. 6:1024-1031.Full Text via DOI: 10.1107/S2052252519011345 PMID: 31709058
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2018N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. STRUCTURE. 26:1604-+.Full Text via DOI: 10.1016/j.str.2018.08.007 PMID: 30270174
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2018Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V. CYTOSKELETON. 75:150-163.Full Text via DOI: 10.1002/cm.21440 PMID: 29500902
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2018
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2018CA(2+)-Induced Movement of Tropomyosin on Native Cardiac Thin Filaments Revealed by Cryoelectron Microscopy. BIOPHYSICAL JOURNAL. 138A-138A.
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2018The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step. JOURNAL OF BIOLOGICAL CHEMISTRY. 293:819-829.Full Text via DOI: 10.1074/jbc.M117.810119 PMID: 29167268
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2018Time-Resolved Cryo-electron Microscopy Using a Microfluidic Chip.. Methods in molecular biology (Clifton, N.J.). 59-71.Full Text via DOI: 10.1007/978-1-4939-7759-8_4 PMID: 29605908
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2017Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 114:6782-6787.Full Text via DOI: 10.1073/pnas.1700868114 PMID: 28607071
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2017Biochemical and Mechanical Properties of the S532P and R712L Cardiomyopathy Myosin Mutants. BIOPHYSICAL JOURNAL. 556A-557A.
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2017Kinetic Characterization of the Mitochondrial Transporter Human Myosin XIX. BIOPHYSICAL JOURNAL. 264A-264A.
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2016C0 and C1 N-Terminal Ig-Domains of Myosin Binding Protein-C Exert Different Effects on thin Filament Activation. BIOPHYSICAL JOURNAL. 125A-125A.
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2016C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113:1558-1563.Full Text via DOI: 10.1073/pnas.1518891113 PMID: 26831109
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2015Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine beta-Cardiac Myosin. BIOCHEMISTRY. 54:1963-1975.Full Text via DOI: 10.1021/bi5015166 PMID: 25680381
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2015Impact of Omecamtiv Mecarbil on Human beta-Cardiac Myosin Structure and Function. BIOPHYSICAL JOURNAL. 445A-445A.
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2014Modulation of Thin Filament Activation of Myosin ATP Hydrolysis by N-Terminal Domains of Cardiac Myosin Binding Protein-C. BIOCHEMISTRY. 53:6717-6724.Full Text via DOI: 10.1021/bi500787f PMID: 25265574
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2014Coupling of Two Non-processive Myosin 5c Dimers Enables Processive Stepping along Actin Filaments. SCIENTIFIC REPORTS. 4.Full Text via DOI: 10.1038/srep04907 PMID: 24809456
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2014Three-Dimensional Organization of Troponin on Cardiac Muscle Thin Filaments in the Relaxed State. BIOPHYSICAL JOURNAL. 106:855-864.Full Text via DOI: 10.1016/j.bpj.2014.01.007 PMID: 24559988
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2014Dependence of the Rate of Phosphate Dissociation from Actomyosin-ADP-Pi Upon the Alkali Light Chains in Skeletal Muscle Myosin. BIOPHYSICAL JOURNAL. 726A-726A.
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2014Negative Stain EM of Myosn-S1 Bound to Actin and Thin Filaments in Mgatp after Rapid Mixing. BIOPHYSICAL JOURNAL. 159A-159A.
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2014Two Molecule of Two Headed Myosin 5C on a DNA Scaffold Steps Processively along Actin Filaments. BIOPHYSICAL JOURNAL. 178A-178A.
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2014Drosophila Myosin-XX Functions as an Actin-Binding Protein To Facilitate the Interaction between Zyx102 and Actin. BIOCHEMISTRY. 53:350-360.Full Text via DOI: 10.1021/bi401236c PMID: 24393048
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20133D-Reconstruction Reveals the Organization of Troponin on Cardiac Thin Filaments. BIOPHYSICAL JOURNAL. 453A-453A.
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2013Activation and Inhibition of F-Actin and Cardiac Thin Filaments by the N-Terminal Domains of Cardiac Myosin Binding Protein C. BIOPHYSICAL JOURNAL. 158A-159A.
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2013Dynamics of the N-Terminal Domain of Myosin V Monitored by FRET. BIOPHYSICAL JOURNAL. 643A-643A.
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2013Engineering of the Myosin Viia Nucleotide-Binding Pocket to Create Selective Sensitivity to N-6-Modified ADP Analogs. BIOPHYSICAL JOURNAL. 644A-644A.
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2013Maximum Activation of Thin Filaments at High Ionic Strength requires Bound Calcium and Rigor Myosin. BIOPHYSICAL JOURNAL. 451A-451A.
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2013
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2012Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:18425-18430.Full Text via DOI: 10.1073/pnas.1212754109 PMID: 23091026
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2012Activation of Cardiac Thin Filaments by N-Terminal Domains of Cardiac Myosin Binding Protein C. BIOPHYSICAL JOURNAL. 435A-435A.
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2012The Shaker-1 Mouse Myosin VIIa has a Drastically Compromised ATP Hydrolysis Mechanism. BIOPHYSICAL JOURNAL. 569A-570A.
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2012Visualization of Troponin on Muscle Thin Filaments by Single Particle Analysis. BIOPHYSICAL JOURNAL. 229A-229A.
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2011The Kinetic Mechanism of Mouse Myosin VIIA. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:8819-8828.Full Text via DOI: 10.1074/jbc.M110.163592 PMID: 21212272
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2010An approach to automated acquisition of cryoEM images from lacey carbon grids. JOURNAL OF STRUCTURAL BIOLOGY. 172:395-399.Full Text via DOI: 10.1016/j.jsb.2010.08.014 PMID: 20817100
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2010Nucleotide-Dependent Shape Changes in the Reverse Direction Motor, Myosin VI. BIOPHYSICAL JOURNAL. 99:3336-3344.Full Text via DOI: 10.1016/j.bpj.2010.09.014 PMID: 21081082
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2010Mechanism of Regulation of Native Cardiac Muscle Thin Filaments by Rigor Cardiac Myosin-S1 and Calcium. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:32760-32769.Full Text via DOI: 10.1074/jbc.M109.098228 PMID: 20696756
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2010Influence of lever structure on myosin 5a walking. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107:2509-2514.Full Text via DOI: 10.1073/pnas.0906907107 PMID: 20133809
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2010Electron Microscopy of Myosin 6 Molecules. BIOPHYSICAL JOURNAL. 723A-723A.
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2010Mechanical and Kinetic Properties of a Myosin 5-SAH Chimera. BIOPHYSICAL JOURNAL. 563A-564A.
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2010Mouse Myosinviia is a Monomeric, "slow" Motor with an Intermediate Duty Ratio. BIOPHYSICAL JOURNAL. 724A-725A.
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2010Myosin 5A Walking Mechanism: The Structural Basis of Slow ADP Dissociatin from the Lead Head. BIOPHYSICAL JOURNAL. 229A-229A.
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2010The Effect of Rigor Myosin Upon the pCa of Calcium Binding to Native Cardiac Thin Filaments. BIOPHYSICAL JOURNAL. 151A-151A.
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2009The SAH domain extends the functional length of the myosin lever. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:22193-22198.Full Text via DOI: 10.1073/pnas.0909851106 PMID: 20018767
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2009Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin. BIOPHYSICAL JOURNAL. 96:3673-3681.Full Text via DOI: 10.1016/j.bpj.2009.01.049 PMID: 19413972
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2009Switch 1 Mutation S217A Converts Myosin V into a Low Duty Ratio Motor. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:2138-2149.Full Text via DOI: 10.1074/jbc.M805530200 PMID: 19008235
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2008Direct observation of the mechanochemical coupling in myosin Va during processive movement. NATURE. 455:128-U99.Full Text via DOI: 10.1038/nature07188 PMID: 18668042
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2008Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:15611-15618.Full Text via DOI: 10.1074/jbc.M710597200 PMID: 18408003
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2008Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:766-773.Full Text via DOI: 10.1074/jbc.M704313200 PMID: 17965414
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2007Real-time measurement of myosin-nucleotide noncovalent complexes by electrospray ionization mass spectrometry. BIOPHYSICAL JOURNAL. 93:914-919.Full Text via DOI: 10.1529/biophysj.106.101618 PMID: 17483158
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2007Mutational analysis of the myosinV active site. BIOPHYSICAL JOURNAL. 493A-493A.
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2007Stopped-flow studies of cGMP phosphodiesterase-5 catalytic mechanism using fluorescently labeled substrate. BIOPHYSICAL JOURNAL. 211A-211A.
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2007The effect of IQ mutations upon the kinetics of ADP dissociation from ActomyosinV-HMM-ADP-Pi. BIOPHYSICAL JOURNAL. 637A-637A.
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2006Structural characterization of the binding of myosin center dot ADP center dot P-i to actin in permeabilized rabbit psoas muscle. BIOPHYSICAL JOURNAL. 91:3370-3382.Full Text via DOI: 10.1529/biophysj.106.086918 PMID: 16905611
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2006Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. BIOCHEMISTRY. 45:13035-13045.Full Text via DOI: 10.1021/bi060712n PMID: 17059220
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2005Calcium regulation of product dissociation from myosin-ADP-Pi by porcine cardiac thin filaments. BIOPHYSICAL JOURNAL. 502A-502A.
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2005Post power stroke lead heads in myosin V. BIOPHYSICAL JOURNAL. 205A-205A.
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2005Structural effects on myosin of three ATPase inhibitors. BIOPHYSICAL JOURNAL. 124A-124A.
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2005Two-headed binding of muscle myosin 2 to F-actin in ATP. BIOPHYSICAL JOURNAL. 18A-18A.
Contact
full name
- Howard D. White
