Thurman, Andrea R.
Overview
overview
-
Employment History
07/09 - Pres Eastern VA Medical School, CONRAD Clinical Research Center, Norfolk, VA
Professor of Obstetrics and Gynecology, Director of Clinical Research Center, Examiner for the American Board of OBGYN, Director of Resident Research, Member EVMS Research and Advisory Committee
09/06 - 06/09 University of Texas Health Sciences Center San Antonio, TX
Clinical Director of Project SAFE Research Clinic (NIAID AI40029).
Assistant Professor, Resident Research Director, Institutional Review Board Member.
10/02 - 08/06 Medical University of South Carolina, Charleston, SC
Assistant Professor, Resident Research Coordinator, Clinical Director of Teen Pregnancy Clinic, Consultant to Public Health Department Nurse Practitioners
10/01 - 10/02 National Naval Medical Center, Bethesda, MD
Assistant Professor, Lieutenant Commander
8/98 - 10/01 United States Naval Hospital, Yokosuka JAPAN
Department Head Obstetrics and Gynecology, Chairman, Blood Bank and Surgical Case Review Committee
Graduate Training and Education
1994 - 1998 National Naval Medical Center, Bethesda, MD and Walter Reed Army Medical Center, Washington, DC Combined Internship and Residency in OBGYN
1990 - 1994 University of Chicago Pritzker School of Medicine, Chicago, IL
Doctor of Medicine (MD)
1986 - 1990 Kenyon College, Gambier, OH, summa cum laude, Phi Beta Kappa
B.A. with honors in Chemistry, B.A. with honors in Studio Art,
Publications
selected publications
-
2022Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 89:87-97.Full Text via DOI: 10.1097/qai.0000000000002820
-
2022Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 226:225.e1-225.e15.Full Text via DOI: 10.1016/j.ajog.2021.09.018
-
2021Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomized Controlled Trial. ECLINICALMEDICINE. 36.Full Text via DOI: 10.1016/j.eclinm.2021.100893 PMID: 34041459
-
2020Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis. NATURE COMMUNICATIONS. 11.Full Text via DOI: 10.1038/s41467-020-19880-w PMID: 33262350
-
2020Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women. NUTRIENTS. 12.Full Text via DOI: 10.3390/nu12103176 PMID: 33080839
-
2019Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0217229 PMID: 31107913
-
2019The Effect of Hormonal Contraception on Cervicovaginal Mucosal End Points Associated with HIV Acquisition. AIDS RESEARCH AND HUMAN RETROVIRUSES. 35:1-12.Full Text via DOI: 10.1089/aid.2018.0298 PMID: 30997816
-
2019A phase I randomized safety study of a single-size silicone rubber diaphragm used with or without a lactic-acid-containing diaphragm gel. CONTRACEPTION. 100:430-437.Full Text via DOI: 10.1016/j.contraception.2019.06.004 PMID: 31442441
-
2019Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir in Healthy Women: Increased Tenofovir Diphosphate in Injectable Depot Medroxyprogesterone Acetate Users. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 80:79-88.Full Text via DOI: 10.1097/QAI.0000000000001864 PMID: 30212395
-
2019Topical Inserts: A Versatile Delivery Form for HIV Prevention. PHARMACEUTICS.Full Text via DOI: 10.3390/pharmaceutics11080374 PMID: 31374941
-
2018Anti-HIV Activity and Drug Concentrations in Tenofovir-based Products: Intravaginal Ring Versus Oral Tablet. AIDS RESEARCH AND HUMAN RETROVIRUSES. 343-343.
-
2018Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir: Increased Tenofovir Diphosphate in Depot Medroxyprogesterone Acetate Users. AIDS RESEARCH AND HUMAN RETROVIRUSES. 342-342.
-
2018HIV Prevention in Healthy Women: Safety and Pharmacokinetics of a Potential New Tenofovir Alafenamide Fumarate (TAF)-based Oral PrEP Regimen. AIDS RESEARCH AND HUMAN RETROVIRUSES. 56-56.
-
2018Testing Objective Markers of Placebo Vaginal Product Adherence in the Field. AIDS RESEARCH AND HUMAN RETROVIRUSES. 26-26.
-
2018Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity. JOURNAL OF CLINICAL INVESTIGATION. 128:4622-4638.Full Text via DOI: 10.1172/JCI120583 PMID: 30222141
-
2018Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using Placebo, Tenofovir and Tenofovir/Levonorgestrel Vaginal Rings. AIDS RESEARCH AND HUMAN RETROVIRUSES. 295-295.
-
2018Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 78:82-92.Full Text via DOI: 10.1097/QAI.0000000000001648 PMID: 29424790
-
2018Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies. CLINICAL AND TRANSLATIONAL MEDICINE. 7.Full Text via DOI: 10.1186/s40169-018-0213-6 PMID: 30402770
-
2017THE EFFECTS OF THE ETONOGESTREL 0.12MG/ETHINYL ESTRADIOL 0.015MG VAGINAL RING (NUVARING (R)) ON INFLAMMATORY BIOMARKERS. FERTILITY AND STERILITY. E121-E121.
-
2017A phase I randomized postcoital testing and safety study of the Caya diaphragm used with 3% Nonoxynol-9 gel, ContraGel or no gel. CONTRACEPTION. 96:124-130.Full Text via DOI: 10.1016/j.contraception.2017.05.016 PMID: 28606382
-
2017Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 33:807-819.Full Text via DOI: 10.1089/aid.2016.0320 PMID: 28398069
-
2017Analytical Advances in the Ex Vivo Challenge Efficacy Assay. AIDS RESEARCH AND HUMAN RETROVIRUSES. 33:395-403.Full Text via DOI: 10.1089/aid.2016.0073 PMID: 27841671
-
2016Assessment of the vaginal residence time of biomarkers of semen exposure. CONTRACEPTION. 94:512-520.Full Text via DOI: 10.1016/j.contraception.2016.05.012 PMID: 27259675
-
2016Can Infrared Spectroscopy (IR) Coupled with Chemometrics Be Used for Objective Measure of Adherence to Microbicide Products?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 94-94.
-
2016Clinical Assessment of New Objective Measures of Adherence for Four Placebo Vaginal Dosage Platforms. AIDS RESEARCH AND HUMAN RETROVIRUSES. 95-95.
-
2016Clinical Performance, Acceptability, and Optimization of Fast-dissolve Vaginal Inserts Designed for HIV-prevention: Results from Two Clinical Studies. AIDS RESEARCH AND HUMAN RETROVIRUSES. 53-53.
-
2016Correlation of Residual Microbicide Levels with Objective Biomarker Analysis to Determine Adherence in a Large Phase III HIV Prevention Trial. AIDS RESEARCH AND HUMAN RETROVIRUSES. 387-387.
-
2016Development and Proof-of-Concept Clinical Evaluation of a Freeze-dried Topical Microbicide Insert for On-demand HIV Prevention. AIDS RESEARCH AND HUMAN RETROVIRUSES. 69-69.
-
2016Epithelial Barrier Alteration and Increased HIV Target Cells Coexist in Inflamed Human Cervices: A Biological Pathway to Enhanced HIV Susceptibility?. AIDS RESEARCH AND HUMAN RETROVIRUSES. 318-318.
-
2016Pharmacokinetics/Pharmacodynamics of Tenofovir and Tenofovir Plus Levonorgestrel Vaginal Rings in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 389-389.
-
2016The Role of Vitamin D on Genital Mucosal Immunity and Markers of HIV Susceptibility in Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 320-320.
-
2016Use of Injectable Depot Medroxyprogesterone Acetate (DMPA) Downregulates Vaginal Epithelial Barrier Genes - Similarly to Mucosal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. 46-46.
-
2016Comparison of Follicular and Luteal Phase Mucosal Markers of HIV Susceptibility in Healthy Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. 32:547-560.Full Text via DOI: 10.1089/aid.2015.0264 PMID: 26750085
-
2015Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity. AIDS RESEARCH AND HUMAN RETROVIRUSES. 31:1139-1152.Full Text via DOI: 10.1089/aid.2015.0006 PMID: 26204200
-
2015Vaginal cytokines do not correlate with postmenopausal vulvovaginal symptoms. GYNECOLOGICAL ENDOCRINOLOGY. 31:317-321.Full Text via DOI: 10.3109/09513590.2014.995080 PMID: 25559048
-
2014Comparison of Visual and Ultraviolet Light Inspection Versus DNA/Protein Biomarkers to Assess Product Adherence With Vaginal Microbicide Applicators. SEXUALLY TRANSMITTED DISEASES. 41:739-746.Full Text via DOI: 10.1097/OLQ.0000000000000209 PMID: 25581811
-
2014Assessment of the Vaginal Residence Time of Biomarkers of Semen Exposure. AIDS RESEARCH AND HUMAN RETROVIRUSES. A172-A172.
-
2014Effect of Bacterial Vaginosis on Markers of Genital Tract Inflammation and Mucosal Immunity: Mechanisms for Susceptibility to HIV Infection. AIDS RESEARCH AND HUMAN RETROVIRUSES. A30-A30.
-
2014GLOBAL ENDOMETRIAL GENE EXPRESSION WITH CONTINUOUS EXPOSURE TO LEVONORGESTREL (LNG) VIA AN INTRAUTERINE SYSTEM (IUS).. FERTILITY AND STERILITY. E141-E141.
-
2014Gene Expression Analysis of Human Vaginal Mucosal Response to Pro-inflammatory Stimuli - Identification of Biomarkers of Vaginal Inflammation. AIDS RESEARCH AND HUMAN RETROVIRUSES. A239-A239.
-
2014Mucosal Susceptibility to HIV-1 and Tenofovir Protection in Explanted Cervicovaginal Tissues from Postmenopausal Compared to Premenopausal Women. AIDS RESEARCH AND HUMAN RETROVIRUSES. A264-A265.
-
2014Multicompartmental Pharmacokinetics of Tenofovir 1% Gel Using the BAT 24 Regimen Versus Daily and Single Pericoital Dosing. AIDS RESEARCH AND HUMAN RETROVIRUSES. A37-A37.
-
2014Vaginal cytokines do not differ between postmenopausal women with and without symptoms of vulvovaginal irritation. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY. 21:840-845.Full Text via DOI: 10.1097/gme.0000000000000179 PMID: 24398407
-
2014Effects of Hormonal Contraception on Antiretroviral Drug Metabolism, Pharmacokinetics and Pharmacodynamics. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 523-530.Full Text via DOI: 10.1111/aji.12210 PMID: 24521428
-
2014Clinical Safety and Pharmacology Trial. MICROBICIDES FOR PREVENTION OF HIV INFECTION. 79-95.Full Text via DOI: 10.1007/82_2013_355 PMID: 24173586
-
2013Vaginal and systemic cytokines in postmenopausal women with and without symptoms of vulvovaginal irritation. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY. 1332-1332.
-
2013Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics. CONTRACEPTION. 87:738-743.Full Text via DOI: 10.1016/j.contraception.2012.11.010 PMID: 23265980
-
2013Depot Medroxyprogesterone Acetate Increases Immune Cell Numbers and Activation Markers in Human Vaginal Mucosal Tissues. AIDS RESEARCH AND HUMAN RETROVIRUSES. 29:592-601.Full Text via DOI: 10.1089/aid.2012.0271 PMID: 23189932
-
2013Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies. INTERNATIONAL JOURNAL OF WOMENS HEALTH. 695-708.Full Text via DOI: 10.2147/IJWH.S34030 PMID: 24174884
-
2012Impact of depot medroxyprogesterone (DMPA) on human vaginal leukocytes and HIV-1 target cells. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 24-24.
-
2012Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention. INTERNATIONAL JOURNAL OF STD & AIDS. 613-619.Full Text via DOI: 10.1258/ijsa.2012.011356 PMID: 23033511
-
2012Safety and Efficacy of WC2031 Versus Vibramycin for the Treatment of Uncomplicated Urogenital Chlamydia trachomatis Infection: A Randomized, Double-blind, Double-Dummy, Active-Controlled, Multicenter Trial. CLINICAL INFECTIOUS DISEASES. 55:82-88.Full Text via DOI: 10.1093/cid/cis291 PMID: 22431798
-
2011SAFETY AND EFFICACY OF WC2031 VS VIBRAMYCIN FOR THE TREATMENT OF UNCOMPLICATED UROGENITAL CHLAMYDIA TRACHOMATIS INFECTION. SEXUALLY TRANSMITTED INFECTIONS. A76-A77.Full Text via DOI: 10.1136/sextrans-2011-050109.123
-
2011Role of Semen in HIV-1 Transmission: Inhibitor or facilitator?. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 292-301.Full Text via DOI: 10.1111/j.1600-0897.2010.00931.x PMID: 21087339
-
2011Innate Immunity and Inflammatory Response to Trichomonas vaginalis and Bacterial Vaginosis: Relationship to HIV Acquisition. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 89-98.Full Text via DOI: 10.1111/j.1600-0897.2010.00902.x PMID: 20678168
-
2011Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.. Infectious diseases in obstetrics and gynecology. 1-10.Full Text via DOI: 10.1155/2011/429403 PMID: 21836811
-
2010One-Year Follow-up of Women With Unfulfilled Postpartum Sterilization Requests. OBSTETRICS AND GYNECOLOGY. 116:1071-1077.Full Text via DOI: 10.1097/AOG.0b013e3181f73eaa PMID: 20966691
-
2010Post-cesarean delivery infectious morbidity: Focus on preoperative antibiotics and methicillin-resistant Staphylococcus aureus. AMERICAN JOURNAL OF INFECTION CONTROL. 38:612-616.Full Text via DOI: 10.1016/j.ajic.2010.02.013 PMID: 20627452
-
2010Mycoplasma genitalium symptoms, concordance and treatment in high-risk sexual dyads. INTERNATIONAL JOURNAL OF STD & AIDS. 21:177-183.Full Text via DOI: 10.1258/ijsa.2009.008485 PMID: 20215621
-
2010An alternative monitoring protocol for single-dose methotrexate therapy in ectopic pregnancy. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 202.Full Text via DOI: 10.1016/j.ajog.2009.09.031 PMID: 19962125
-
2009Effect of acculturation on the acceptability of potential microbicides and sexual risk-taking.. SEXUALLY TRANSMITTED DISEASES. 36:387-94.Full Text via DOI: 10.1097/olq.0b013e318198d90c PMID: 19556933
-
2009The male sexual partners of adult versus teen women with sexually transmitted infections.. SEXUALLY TRANSMITTED DISEASES. 36:768-74.Full Text via DOI: 10.1097/olq.0b013e3181b2c68d PMID: 19704393
-
2009Unfulfilled postpartum sterilization requests.. JOURNAL OF REPRODUCTIVE MEDICINE. 54:467-72.PMID: 19769190
-
2008Methicillin-resistant Staphylococcus aureus as a common cause of vulvar abscesses.. OBSTETRICS AND GYNECOLOGY. 112:538-44.Full Text via DOI: 10.1097/aog.0b013e3181827829 PMID: 18757650
-
2008Partner notification of sexually transmitted infections among pregnant women.. INTERNATIONAL JOURNAL OF STD & AIDS. 19:309-15.Full Text via DOI: 10.1258/ijsa.2007.007295 PMID: 18482960
-
2008Partner notification of sexually transmitted infections: a large cohort of Mexican American and African American women.. SEXUALLY TRANSMITTED DISEASES. 35:136-40.Full Text via DOI: 10.1097/olq.0b013e318151498f PMID: 17898679
-
2008Preventing recurrent sexually transmitted diseases in minority adolescents: a randomized controlled trial.. OBSTETRICS AND GYNECOLOGY. 111:1417-25.Full Text via DOI: 10.1097/aog.0b013e318177143a PMID: 18515527
-
2008The influence of depression on sexual risk reduction and STD infection in a controlled, randomized intervention trial.. SEXUALLY TRANSMITTED DISEASES. 35:898-904.Full Text via DOI: 10.1097/olq.0b013e31817d7a33 PMID: 18607311
-
2007Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis.. CONTRACEPTION. 76:49-52.Full Text via DOI: 10.1016/j.contraception.2007.03.006 PMID: 17586137
-
2007Preventing repeat teen pregnancy: postpartum depot medroxyprogesterone acetate, oral contraceptive pills, or the patch?. Journal of pediatric and adolescent gynecology. 20:61-5.Full Text via DOI: 10.1016/j.jpag.2006.11.006 PMID: 17418388
-
2006Bacteriuria in pregnant women with sickle cell trait. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 194:1366-70.Full Text via DOI: 10.1016/j.ajog.2005.11.022 PMID: 16647923
-
2006Endometrial histology of Depomedroxyprogesterone acetate users: a pilot study.. Infectious diseases in obstetrics and gynecology. 2006:69402.Full Text via DOI: 10.1155/idog/2006/69402 PMID: 17093355
-
2006Patient acceptance of medical student participation in an outpatient obstetric/gynecologic clinic.. JOURNAL OF REPRODUCTIVE MEDICINE. 51:109-14.PMID: 16572911
-
2004Non-pregnant patients' preference for delivery route.Full Text via DOI: 10.1007/s00192-004-1164-6 PMID: 15580415
-
2004Pregnant adolescents' preferences for labor pain management.. SOUTHERN MEDICAL JOURNAL. 97:964-7.Full Text via DOI: 10.1097/01.smj.0000140826.59820.73 PMID: 15558923
-
2004Vulvar cancer with Fanconi's anemia and neutropenic fever: a case report.. JOURNAL OF REPRODUCTIVE MEDICINE. 49:218-21.PMID: 15098894
-
2002Markedly elevated beta-hCG levels in a normal singleton gestation with hyperreactio luteinalis.. OBSTETRICS AND GYNECOLOGY. 99:958-61.Full Text via DOI: 10.1016/s0029-7844(02)01983-x PMID: 11975975
-
2002Puerperal diastasis of the pubic symphysis. A case report.. JOURNAL OF REPRODUCTIVE MEDICINE. 47:581-3.PMID: 12170537
-
2000Laboratory testing for preeclampsia: result trends and screening recommendations.. MILITARY MEDICINE. 165:546-8.PMID: 10920656
-
2000Neisseria gonorrhoeae screening in pregnancy. MILITARY MEDICINE. 165:549-51.PMID: 10920657
-
2000Use of the endometrial pipelle in the diagnosis of early abnormal gestations. FERTILITY AND STERILITY. 74:593-5.Full Text via DOI: 10.1016/s0015-0282(00)00683-x PMID: 10973661
-
1999Pelvic inflammatory disease in a diabetic patient after endometrial biopsy. OBSTETRICAL & GYNECOLOGICAL SURVEY. 54:283-4.Full Text via DOI: 10.1097/00006254-199905000-00001 PMID: 10234696
-
1998Evaluation of routine antepartum and postpartum blood counts.. JOURNAL OF REPRODUCTIVE MEDICINE. 43:581-5.PMID: 9693408
-
1998Myonecrosis of the rectus muscle after a Cherney incision.. Gynecologic oncology. 68:66-8.Full Text via DOI: 10.1006/gyno.1997.4898 PMID: 9454663
-
1990Anionic complex-carbohydrate units of human thyroglobulin.. ENDOCRINOLOGY. 127:2056-63.Full Text via DOI: 10.1210/endo-127-5-2056 PMID: 2226299
Research
research overview
- My primary research interests are in conducting translational clinical studies. The studies focus on contraceptive and HIV prevention product safety and mechanisms. I am also interested in the impact of reproductive tract infections and hormones on lower genital tract mucosal responses.
principal investigator on
projects
-
Current Project
Contact
preferred title
- Professor of Obstetrics and Gynecology
full name
- Andrea R. Thurman, MD
visualizations
Recent publications and grants in Researchers@EVMS
research areas
- Endocrinology & Metabolism
- General & Internal Medicine
- Health Care Sciences & Services
- Immunology
- Infectious Diseases
- Microbiology
- Obstetrics & Gynecology
- Oncology
- Pediatrics
- Pharmacology & Pharmacy
- Public, Environmental & Occupational Health
- Reproductive Biology
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Virology