Bocca, Silvina M.

Silvina M. Bocca
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Offers student research opportunities

Positions

Professor Of Obgyn, Rei, Obstetrics and Gynecology

Contact Info

boccas@evms.edu

EVMS Directory Profile

research overview

1. IVF ovarian stimulation

2. Implantation studies-endometrial markers:

3. Implantation studies-embryo markers:

overview

Department of Biological Sciences, University of Buenos Aires, Argentina

M.S.

Biology 1982-1987 Molecular and Cell Biology

Biomedical Sciences Program, Old Dominion University-Eastern Virginia Medical School, Norfolk, VA Ph.D. 1989-1994 Reproductive Biology

Eastern Virginia Medical School, Norfolk, VA M.D. 1994-1998 Medicine

Eastern Virginia Medical School, Norfolk, VA Specialty 1998-2002 Ob Gyn Residency

The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA

Sub-specialty fellowship 2002-2005 Reproductive Endocrinology and Infertility

projects

Current Project
- 2018-present, Thesis Director-PhD in Embryology, Tamar Alkon, MD, MSc, TNFα and MFG-E8: novel biomarkers to predict implantation failure
- Clinical outcomes following ICSI cycles using surgically recovered sperm and the impact of maternal age: 2004-2015 SART CORS registry

selected publications

2019

Possible Endometrial Angiogenic Role of MFGE8 and Its Ability to Predict Implantation Failure in IVF.. REPRODUCTIVE SCIENCES. 289A-290A.
2019

Knowledge and attitudes regarding elective oocyte cryopreservation in undergraduate and medical students.. Fertility research and practice. 5.
Full Text via DOI: 10.1186/s40738-019-0057-9 PMID: 31007938
2018

RISK OF CONGENITAL MALFORMATIONS IN ICSI WITH SURGICALLY OBTAINED SPERM: A US STUDY IN FOUR STATES.. FERTILITY AND STERILITY. E290-E291.
2018

Clinical outcomes following ICSI cycles using surgically recovered sperm and the impact of maternal age: 2004-2015 SART CORS registry. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 35:1239-1246.
Full Text via DOI: 10.1007/s10815-018-1234-1 PMID: 29926376
2018

A novel male 2;4;14 complex chromosomal translocation with normal semen parameters but 100% embryonic aneuploidy. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 35:907-912.
Full Text via DOI: 10.1007/s10815-018-1126-4 PMID: 29380280
2018

TNFa and MFG-E8: Novel Biomarkers to Predict Implantation Failure. REPRODUCTIVE SCIENCES. 246A-246A.
2017

Psychological and emotional concomitants of infertility diagnosis in women with diminished ovarian reserve or anatomical cause of infertility. FERTILITY AND STERILITY. 108:161-167.
Full Text via DOI: 10.1016/j.fertnstert.2017.05.008 PMID: 28579416
2017

ICSI Outcomes in Men Undergoing TESA for Azoospermia and Impact of Maternal Age.. REPRODUCTIVE SCIENCES. 233A-233A.
2017

ICSI outcomes in men undergoing TESE for azoospermia and impact of maternal age. ANDROLOGIA. 49.
Full Text via DOI: 10.1111/and.12617 PMID: 27198124
2016

MFGE8 regulates TGF-beta-induced epithelial mesenchymal transition in endometrial epithelial cells in vitro. REPRODUCTION. 152:225-233.
Full Text via DOI: 10.1530/REP-15-0585 PMID: 27340235
2016

TNF alpha and Milk Fat Globule-EGF Factor 8 Protein (MFG-E8): Biomarkers to Predict Implantation Outcome?. REPRODUCTIVE SCIENCES. 254A-254A.
2016

Transcriptome of early embryonic invasion at implantation sites in a murine model. REPRODUCTION FERTILITY AND DEVELOPMENT. 28:1487-1498.
Full Text via DOI: 10.1071/RD14166
2015

A randomized controlled trial of luteal phase supplementation with vaginal progesterone in women with polycystic ovary syndrome undergoing ovulation induction with letrozole. HUMAN REPRODUCTION. 429-429.
2015

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 32:395-400.
Full Text via DOI: 10.1007/s10815-014-0402-1 PMID: 25563580
2015

Letrozole as First Time Treatment for Infertility: A Cost Effective Option in a Non-Mandated State. REPRODUCTIVE SCIENCES. 217A-217A.
2015

Role of Vitamin D Deficiency in Male Fertility. FERTILITY AND STERILITY. E39-E39.
2014

Antimullerian hormone regulates stem cell factor expression in human granulosa cells. FERTILITY AND STERILITY. 102:1742-U578.
Full Text via DOI: 10.1016/j.fertnstert.2014.08.012 PMID: 25241372
2014

AMH REGULATES SCF VIA THE CAMP/PKA PATHWAY IN HUMAN GRANULOSA CELLS. FERTILITY AND STERILITY. E150-E150.
2014

LUTEAL PHASE SUPPLEMENTATION WITH VAGINAL PROGESTERONE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME AND OVULATORY DYSFUNCTION UNDERGOING OVULATION INDUCTION WITH LETROZOLE: A RANDOMIZED CONTROLLED TRIAL.. FERTILITY AND STERILITY. E237-E237.
2014

SIGNALING THRU MILK FAT GLOBULE EGF FACTOR 8 ON HUMAN ENDOMETRIAL ENDOTHELIAL CELLS PROMOTES ANGIOGENESIS.. FERTILITY AND STERILITY. E295-E296.
2014

Characterization of secreted proteins of 2-cell mouse embryos cultured in vitro to the blastocyst stage with and without protein supplementation. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 31:757-765.
Full Text via DOI: 10.1007/s10815-014-0207-2 PMID: 24658922
2014

Expresion of Adipokine Receptors in Endometrial Cells during In Vitro Decidualization. REPRODUCTIVE SCIENCES. 323A-323A.
2014

MFG-E8 and Its Receptor Integrin alpha vb3 Are Involved in the Attachment of Human Trophoblasts to the Endometrial Epithelium.. REPRODUCTIVE SCIENCES. 226A-226A.
2014

Role for the endometrial epithelial protein MFG-E8 and its receptor integrin alpha v beta 3 in human implantation: results of an in vitro trophoblast attachment study using established human cell lines. FERTILITY AND STERILITY. 101:874-882.
Full Text via DOI: 10.1016/j.fertnstert.2013.12.015 PMID: 24424369
2014

Tumor necrosis factor alpha up-regulates endometrial milk fat globule-epidermal growth factor 8 protein production via nuclear factor kappa B activation, resulting in cell migration of epithelial cells. FERTILITY AND STERILITY. 101:552-559.
Full Text via DOI: 10.1016/j.fertnstert.2013.10.032 PMID: 24262600
2013

LOW DOSE HUMAN CHORIONIC GONADOTROPIN MAY BE A COST EFFECTIVE ALTERNATIVE TO HUMAN MENOPAUSAL GONADOTROPIN FOR OVARIAN STIMULATION DURING IN VITRO FERTILIZATION CYCLES.. FERTILITY AND STERILITY. S260-S260.
2013

MILK FAT GLOBULE EGF FACTOR 8 (MFG-E8) MEDIATES TRANSFORMING GROWTH FACTOR BETA (TGF- beta) INDUCED EPITHELIAL MESENCHYMAL TRANSITION (EMT) IN HUMAN ENDOMETRIAL EPITHELIUM CONTRIBUTING TO IMPLANTATION. FERTILITY AND STERILITY. S75-S75.
2013

Sex Steroids Regulate Epithelial-Stromal Cell Cross Talk and Trophoblast Attachment Invasion in a Three-Dimensional Human Endometrial Culture System. TISSUE ENGINEERING PART C-METHODS. 19:676-687.
Full Text via DOI: 10.1089/ten.tec.2012.0616 PMID: 23320930
2013

Modulation of the Expression of the Transcription Factors T-Bet and GATA-3 in Immortalized Human Endometrial Stromal Cells (HESCs) by Sex Steroid Hormones and cAMP. REPRODUCTIVE SCIENCES. 20:699-709.
Full Text via DOI: 10.1177/1933719112466297 PMID: 23308012
2013

The interaction between decidualized stromal cells and trophoblast stimulates expression of metalloproteinases to regulate trophoblast invasion in a novel three dimensional (3D) human implantation model. HUMAN REPRODUCTION. 209-209.
2013

The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach. MOLECULAR HUMAN REPRODUCTION. 19:250-263.
Full Text via DOI: 10.1093/molehr/gas063 PMID: 23247814
2013

Influence of Exposure to Benzo[a]pyrene on Mice Testicular Germ Cells during Spermatogenesis. JOURNAL OF TOXICOLOGY.
Full Text via DOI: 10.1155/2013/387850 PMID: 24454362
2013

Use of 3-Dimensional Sonography to Assess Uterine Anomalies
Full Text via DOI: 10.7863/jum.2013.32.1.1 PMID: 23269704
2013

Use of 3-Dimensional Sonography to Assess Uterine Anomalies. JOURNAL OF ULTRASOUND IN MEDICINE. 32:1-6.
2012

Epithelial cell protein milk fat globule-epidermal growth factor 8 and human chorionic gonadotropin regulate stromal cell apoptosis in the human endometrium. FERTILITY AND STERILITY. 98:1549-+.
Full Text via DOI: 10.1016/j.fertnstert.2012.07.1127 PMID: 22921913
2012

Milk fat globule epidermal growth factor 8 (MFG-E8): A novel protein in the mammalian endometrium with putative roles in implantation and placentation. PLACENTA. 33:795-802.
Full Text via DOI: 10.1016/j.placenta.2012.06.015 PMID: 22770563
2012

Does the degree of hypothalamic-pituitary-ovarian recovery after oral contraceptive pills affect outcomes of IVF/ICSI cycles receiving GnRH-antagonist adjuvant therapy in women over 35 years of age?. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 29:877-882.
Full Text via DOI: 10.1007/s10815-012-9812-0 PMID: 22729431
2012

THE SEARCH FOR BIOMARKERS OF HUMAN EMBRYO DEVELOPMENTAL POTENTIAL IN IVF: A COMPREHENSIVE PROTEOMIC APPROACH.. FERTILITY AND STERILITY. S272-S272.
2012

Cross-Talk between Epithelial and Stromal Cells: Evidence of Paracrine Effects Using a Novel Human Endometrial Three-Dimensional (3D) Culture System.. REPRODUCTIVE SCIENCES. 99A-99A.
2012

Transcriptomics of Early Embryonic Invasion at Implantation Sites in a Murine Model. REPRODUCTIVE SCIENCES. 274A-274A.
2012

A Study of the Cost, Accuracy, and Benefits of 3-Dimensional Sonography Compared With Hysterosalpingography in Women With Uterine Abnormalities. JOURNAL OF ULTRASOUND IN MEDICINE. 31:81-85.
Full Text via DOI: 10.7863/jum.2012.31.1.81 PMID: 22215773
2012

A Study of the Cost, Accuracy, and Benefits of 3-Dimensional Sonography Compared With Hysterosalpingography in Women With Uterine Abnormalities. JOURNAL OF ULTRASOUND IN MEDICINE. 31:81-85.
2012

A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroids. MOLECULAR HUMAN REPRODUCTION. 18:33-43.
Full Text via DOI: 10.1093/molehr/gar064 PMID: 21989169
2011

Timing of Oocyte Retrieval and Embryo Transfer with Pregnancy Duration. JOURNAL OF WOMENS HEALTH. 20:1669-1675.
Full Text via DOI: 10.1089/jwh.2011.2836 PMID: 21970598
2011

ANTI-MULLERIAN HORMONE (AMH) LEVELS IN SERUM AS PREDICTORS OF OVARIAN RESPONSE AND PREGNANCIES IN BOTH INFERTILE AND FERTILE WOMEN UNDERGOING IVF OR OOCYTE DONATION CYCLES. FERTILITY AND STERILITY. S55-S56.
2011

Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 28:771-772.
Full Text via DOI: 10.1007/s10815-011-9596-7 PMID: 21656182
2011

THE INCIDENCE OF DNA FRAGMENTATION IN MORPHOLOGICALLY NORMAL SPERM IS A BETTER PREDICTOR OF ICSI OUCOME THAN THE EVALUATION OF DNA FRAGMENTATION IN THE TOTAL SPERM POPULATION. FERTILITY AND STERILITY. S158-S158.
2011

Gonadotrophin ovulation induction and enhancement outcomes: analysis of more than 1400 cycles. REPRODUCTIVE BIOMEDICINE ONLINE. 23:220-226.
Full Text via DOI: 10.1016/j.rbmo.2011.05.002 PMID: 21665547
2011

Expression of milk fat globule EGF-factor 8 (MFG-E8) mRNA and protein in the human endometrium and its regulation by prolactin. MOLECULAR HUMAN REPRODUCTION. 17:360-371.
Full Text via DOI: 10.1093/molehr/gaq102 PMID: 21177637
2011

Do Assisted Reproductive Techniques Increase Vanishing Twin Syndrome?. FERTILITY AND STERILITY. S18-S18.
2011

Live birth from a frozen-thawed pronuclear stage embryo almost 20 years after its cryopreservation. FERTILITY AND STERILITY.
Full Text via DOI: 10.1016/j.fertnstert.2010.08.056 PMID: 20887984
2011

Modulation of the Expression of T-bet/GATA-3 in Human Endometrial Stromal Cells by Steroid Hormones. REPRODUCTIVE SCIENCES. 231A-231A.
2011

Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States. FERTILITY AND STERILITY. 95:528-533.
Full Text via DOI: 10.1016/j.fertnstert.2010.04.057 PMID: 20547390
2011

Anti-Mullerian hormone serum levels predict response to controlled ovarian hyperstimulation but not embryo quality or pregnancy outcome in oocyte donation. FERTILITY AND STERILITY. 410-412.
Full Text via DOI: 10.1016/j.fertnstert.2010.07.1042 PMID: 20736131
2011

The impact of a gonadotropin-releasing hormone antagonist on gonadotropin ovulation induction cycles in women with polycystic ovary syndrome: a prospective randomized study. FERTILITY AND STERILITY. 95:216-220.
Full Text via DOI: 10.1016/j.fertnstert.2010.05.023 PMID: 20594551
2010

A cross-sectional evaluation of the first cohort of young adults conceived by in vitro fertilization in the United States. FERTILITY AND STERILITY. 94:2043-2049.
Full Text via DOI: 10.1016/j.fertnstert.2009.12.023 PMID: 20159654
2010

A NOVEL IN VITRO MODEL OF HUMAN IMPLANTATION: AN ENDOMETRIUM-LIKE THREE-DIMENSIONAL (3D) CULTURE SYSTEM FOR ATTACHMENT/INVASION OF TROPHOBLAST-LIKE CELLS. FERTILITY AND STERILITY. S64-S65.
2010

MILK FAT GLOBULE EPITHELIAL GROWTH FACTOR 8 (MFGE8) REGULATES HUMAN ENDOMETRIAL ENDOTHELIAL CELL ADHESION AND PROLIFERATION.. FERTILITY AND STERILITY. S215-S216.
2010

Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 20:848-856.
Full Text via DOI: 10.1016/j.rbmo.2010.03.005 PMID: 20378414
2010

Do GnRH analogues directly affect human endometrial epithelial cell gene expression?. MOLECULAR HUMAN REPRODUCTION. 16:347-360.
Full Text via DOI: 10.1093/molehr/gaq012 PMID: 20203127
2010

Do GnRH Analogues Affect Human Endometrial Epithelial Cell Gene Expression?. REPRODUCTIVE SCIENCES. 143A-143A.
2010

Milk Fat Globule-Epidermal Growth Factor 8 (MFG-E8): A Novel Protein Upregulated in the Receptive Endometrium and in Cytotrophoblasts throughout Implantation and Placentation. REPRODUCTIVE SCIENCES. 244A-245A.
2010

Two singleton live births after the transfer of cryopreserved-thawed day-3 embryos following an unstimulated in-vitro oocyte maturation cycle. REPRODUCTIVE BIOMEDICINE ONLINE. 20:387-390.
Full Text via DOI: 10.1016/j.rbmo.2009.12.005 PMID: 20093088
2010

Reproductive efficiency of human oocytes fertilized in vitro. FACTS VIEWS AND VISION IN OBGYN. 2:169-171.
PMID: 25013707
2009

Automated assessment of ovarian follicles using a novel three-dimensional ultrasound software. FERTILITY AND STERILITY. 92:1562-1568.
Full Text via DOI: 10.1016/j.fertnstert.2008.08.102 PMID: 18937942
2009

Pilot study evaluating a progesterone vaginal ring for luteal-phase replacement in donor oocyte recipients. FERTILITY AND STERILITY. 92:1600-1605.
Full Text via DOI: 10.1016/j.fertnstert.2008.08.085 PMID: 18990373
2009

Fragmentation of DNA in morphologically normal human spermatozoa. FERTILITY AND STERILITY. 91:1077-1084.
Full Text via DOI: 10.1016/j.fertnstert.2008.01.015 PMID: 18440529
2009

Global Genomic Analysis of Endometrial Genes Critically Involved in the Invasive Phase of Murine Implantation. REPRODUCTIVE SCIENCES. 260A-261A.
2008

Expression of immunomodulatory genes, their protein products and specific ligands/receptors during the window of implantation in the human endometrium. MOLECULAR HUMAN REPRODUCTION. 14:413-421.
Full Text via DOI: 10.1093/molehr/gan029 PMID: 18524812
2008

Oocytes of baboon fetal primordial ovarian follicles express estrogen receptor beta mRNA. ENDOCRINE. 33:254-260.
Full Text via DOI: 10.1007/s12020-008-9081-y PMID: 18484193
2008

Detection of transient postoperative changes in the endometrial cavity by 3-dimensional ultrasonography after hysteroscopic correction of various uterine anomalies. JOURNAL OF ULTRASOUND IN MEDICINE. 27:461-465.
2007

Automated assessment of follicular volumetric parameters using three dimensional sonography. A prospective validation of a novel software program.. FERTILITY AND STERILITY. S81-S81.
2007

Automated calculation of ovarian follicular diameters using three dimensional sonography in women undergoing in vitro fertilization (IVF): a prospective evaluation of a novel software.. FERTILITY AND STERILITY. S80-S80.
2007

Clinical evaluation of a novel automated follicular assessment software program in women undergoing controlled ovarian hyperstimulation for in vitro fertilization using three dimensional sonography.. FERTILITY AND STERILITY. S80-S80.
2007

Differential gene expression and immunolocation of proteins of high functional significance throughout the window of implantation.. FERTILITY AND STERILITY. S106-S106.
2007

Effect of infertility diagnosis on live birth rates and pregnancy rates in 629 cycles of ovulation induction and ovulation enhancement with gonadotropins.. FERTILITY AND STERILITY. S266-S266.
2007

Impact of cryopreservation length of storage time on embryo thaw survival and live birth rates a review of 19,470 cryopreserved embryos.. FERTILITY AND STERILITY. S344-S344.
2007

Milk fat globule-EGF-factor 8 (MFG-E8), a protein linking apoptotic cells to phagocytes, is expressed in human endometrium during the window of implantation. FERTILITY AND STERILITY. S156-S156.
2007

Three dimensional ultrasound (3D US): High accuracy, low cost and minimal discomfort in the diagnosis of uterine anomalies.. FERTILITY AND STERILITY. S203-S203.
2007

Current status of robotically assisted laparoscopic surgery in reproductive medicine and gynaecology. REPRODUCTIVE BIOMEDICINE ONLINE. 765-772.
2007

Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 24:111-117.
Full Text via DOI: 10.1007/s10815-006-9101-x PMID: 17450430
2007

Uncomplicated full term pregnancy after da Vinci-assisted laparoscopic myomectomy. REPRODUCTIVE BIOMEDICINE ONLINE. 14:246-249.
2007

Elective transfer of two embryos: Reduction of multiple gestations while maintaining high pregnancy rates. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 24:11-15.
Full Text via DOI: 10.1007/s10815-006-9085-6 PMID: 17186398
2006

Differential gene expression in isolated endometrial glandular and stromal cells throughout the window of implantation.. FERTILITY AND STERILITY. S339-S339.
2006

The Z technique: An easy approach to the display of the midcoronal plane of the uterus in volume sonography. JOURNAL OF ULTRASOUND IN MEDICINE. 25:607-612.
2005

Effect of coasting on the implantation potential of embryos transferred after cryopreservation and thawing. FERTILITY AND STERILITY. 84:867-874.
Full Text via DOI: 10.1016/j.fertnstert.2005.03.069 PMID: 16213837
2005

Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. FERTILITY AND STERILITY. 555-569.
Full Text via DOI: 10.1016/j.fertnstert.2005.02.053 PMID: 16169382
2005

Cumulative exposure to esradiol (E-2) during the follicular phase of controlled ovarian hyperstimulation (COH) cycles: Effect on IVF outcome.. FERTILITY AND STERILITY. S278-S278.
2005

Estrogen and progesterone response elements in genes relevant for human embryo implantation identified by microarray/bioinformatics.. FERTILITY AND STERILITY. S236-S237.
2005

Raloxifene (Rix) effects on vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) are not mediated by changes in steroid receptor (SR) co-repressors or co-activators or cell proliferation markers in a human endometrial cell line.. FERTILITY AND STERILITY. S230-S230.
2005

Raloxifene (Rix) has antiestrogenic effect on vascular endothelial growth factor (VEGF) mRNA and protein while down-regulating progesterone receptors in a human endometrial cell line in vitro.. FERTILITY AND STERILITY. S229-S230.
2005

Raloxifene shows progestagenic effects on thrombospondin-1 (TSP-1) and down-regulation of progesterone receptors in a human endometrial cell line.. FERTILITY AND STERILITY. S119-S120.
2005

In search of candidate genes critically expressed in the human endometrium during the window of implantation. HUMAN REPRODUCTION. 20:2104-2117.
Full Text via DOI: 10.1093/humrep/dei051 PMID: 15878921

preferred title

Professor Of Obgyn, Rei

full name

Silvina M. Bocca, MD, PhD, HCLD

principal investigator on

TNFα (Tumor Necrosis Factor Alpha) and MFG-E8 (Milk Fat Globule-Epidermal Growth Factor 8): Novel Biomarkers to Predict Implantation Failure

recognition and awards

2019- Top Doctor, Coastal Virginia Magazine
2018- Faculty Award for Mentoring, EVMS
2018- Top Doctor, Coastal Virginia Magazine
2015- America's Top ObGyns
2015- Top Doctor, Coastal Virginia Magazine
2014- Top Doctor, Hampton Roads Magazine
2013- America's Top Obstetricians & Gynecologists Award, Consumers' Research Council of America
2013- Top Doctor, Hampton Roads Magazine
2013- ASRM Star Award
2012- Top Doctor, Hampton Roads Magazine
2012- Top Doctor, International Association of Healthcare Professionals
2011- Hampton Roads Health Care Hero from Inside Business (letter from Mark. R. Warner, US Senator)
2010- Hampton Roads Top Docs by Hampton Roads Magazine
2008- Virginia Top Docs by Hampton Roads Magazine
2008- AOA alumna, EVMS