Semmes, IV, O. John
- Anthem Distinguished Professor, Associate Dean For Translational Research, Director Leroy T Canoles Jr Cancer Research Center, Microbiology and Molecular Cell Biology
Publications
selected publications
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2022Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy. PROSTATE CANCER AND PROSTATIC DISEASES.Full Text via DOI: 10.1038/s41391-022-00591-w PMID: 36097168
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2022Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. JOURNAL OF EXTRACELLULAR VESICLES. 11.Full Text via DOI: 10.1002/jev2.12184 PMID: 35119778
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2021Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles. FRONTIERS IN CHEMISTRY. 9.Full Text via DOI: 10.3389/fchem.2021.734280 PMID: 34646811
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2021Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry. NATURE REVIEWS UROLOGY.Full Text via DOI: 10.1038/s41585-021-00500-1 PMID: 34453155
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2021NF-kappa B-induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 118.Full Text via DOI: 10.1073/pnas.2005568118 PMID: 33649200
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2020Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination. PROTEOMICS CLINICAL APPLICATIONS.Full Text via DOI: 10.1002/prca.202000012 PMID: 32614141
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2020Correction: The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1.. PLOS PATHOGENS. 16:e1009135.Full Text via DOI: 10.1371/journal.ppat.1009135 PMID: 33306747
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2020Prostate Cancer Biomarker Development: National Cancer Institute's Early Detection Research Network Prostate Cancer Collaborative Group Review.. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 29:2454-2462.Full Text via DOI: 10.1158/1055-9965.epi-20-1104 PMID: 33093161
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2020RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia.. PLOS PATHOGENS. 16:e1008618.Full Text via DOI: 10.1371/journal.ppat.1008618 PMID: 32453758
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2019Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 39:2168-2191.Full Text via DOI: 10.1161/ATVBAHA.119.312826 PMID: 31434495
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2018A Lipidomics Approach to Identifying Key Lipid Species Involved in VEGF-Inhibitor Mediated Attenuation of Bleomycin-Induced Pulmonary Fibrosis. PROTEOMICS CLINICAL APPLICATIONS. 12.Full Text via DOI: 10.1002/prca.201700086 PMID: 29283216
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2018Characterization and Evidence of the miR-888 Cluster as a Novel Cancer Network in Prostate. MOLECULAR CANCER RESEARCH. 16:669-681.Full Text via DOI: 10.1158/1541-7786.MCR-17-0321 PMID: 29330297
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2017Changes in the Hippocampal Proteome Associated with Spatial Memory Impairment after Exposure to Low (20 cGy) Doses of 1 GeV/ n Fe-56 Radiation. RADIATION RESEARCH. 187:287-297.Full Text via DOI: 10.1667/RR14067.1 PMID: 28156212
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2016HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. VIRUSES-BASEL.Full Text via DOI: 10.3390/v8060161 PMID: 27322308
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2016Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. NATURE COMMUNICATIONS. 7.Full Text via DOI: 10.1038/ncomms11906 PMID: 27350604
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2016A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis. PROTEOMICS. 16:33-46.Full Text via DOI: 10.1002/pmic.201500171 PMID: 26425798
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2016Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. JOURNAL OF CELLULAR PHYSIOLOGY. 231:1364-1374.Full Text via DOI: 10.1002/jcp.25240 PMID: 26530043
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2015Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.
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2015
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2015From profiling to function: A role for microRNA miR-888 in promoting prostate cancer progression. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-3086
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2015HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. PLOS PATHOGENS. 11.Full Text via DOI: 10.1371/journal.ppat.1005102 PMID: 26285145
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2015Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.Full Text via DOI: 10.18632/oncotarget.6193 PMID: 26497208
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2015Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort. EUROPEAN JOURNAL OF NEUROLOGY. 22:591-599.Full Text via DOI: 10.1111/ene.12534 PMID: 25104396
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2014The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1. PLOS PATHOGENS. 10.Full Text via DOI: 10.1371/journal.ppat.1004343 PMID: 25211330
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2014Histone Deacetylase Inhibitors Potentiate Vesicular Stomatitis Virus Oncolysis in Prostate Cancer Cells by Modulating NF-kappa B-Dependent Autophagy. JOURNAL OF VIROLOGY. 88:2927-2940.Full Text via DOI: 10.1128/JVI.03406-13 PMID: 24371063
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2014miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. CELL CYCLE. 13:227-239.Full Text via DOI: 10.4161/cc.26984 PMID: 24200968
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2014MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma. Oncoscience. 1:725.Full Text via DOI: 10.18632/oncoscience.99
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2013Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1. JOURNAL OF VIROLOGY. 87:11516-11524.Full Text via DOI: 10.1128/JVI.01642-13 PMID: 23966382
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2013Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. PROTEOMICS CLINICAL APPLICATIONS. 7:677-689.Full Text via DOI: 10.1002/prca.201200134 PMID: 23775902
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2013In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. PROTEOMICS. 13:1667-1671.Full Text via DOI: 10.1002/pmic.201200561 PMID: 23533145
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2013The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach. MOLECULAR HUMAN REPRODUCTION. 19:250-263.Full Text via DOI: 10.1093/molehr/gas063 PMID: 23247814
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2013Focus on cancer proteomics.. PROTEOMICS CLINICAL APPLICATIONS. 7:315.Full Text via DOI: 10.1002/prca.201370034 PMID: 23780814
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2013Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription. JOURNAL OF VIROLOGY. 87:4360-4371.Full Text via DOI: 10.1128/jvi.02574-12 PMID: 23388725
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2012Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 11:1870-1884.Full Text via DOI: 10.1074/mcp.M112.017889 PMID: 22986220
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2012NADiA ProsVue Prostate-specific Antigen Slope Is an Independent Prognostic Marker for Identifying Men at Reduced Risk of Clinical Recurrence of Prostate Cancer After Radical Prostatectomy. UROLOGY. 80:1319-1325.Full Text via DOI: 10.1016/j.urology.2012.06.080 PMID: 23107099
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2012Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. CARCINOGENESIS. 33:2208-2219.Full Text via DOI: 10.1093/carcin/bgs213 PMID: 22782996
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2012BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:9575-9580.Full Text via DOI: 10.1073/pnas.1207496109 PMID: 22645331
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2012Post-prostatectomy PSA slope (ProsVue) in Gleason score >= 7 disease. JOURNAL OF CLINICAL ONCOLOGY.
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2012Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine. JOURNAL OF PROTEOME RESEARCH. 11:2386-2396.Full Text via DOI: 10.1021/pr2011236 PMID: 22339264
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2012The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax. BLOOD. 119:1173-1181.Full Text via DOI: 10.1182/blood-2011-06-358564 PMID: 22106342
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2012Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY. 84:141-148.Full Text via DOI: 10.1021/ac2021322 PMID: 22098105
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2012Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management. Principles of Molecular Diagnostics and Personalized Cancer Medicine. Ed. Lynch, H. Lippincott, Williams & Wilkins.
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2011Functional and physical interaction between the mismatch repair and FA-BRCA pathways. HUMAN MOLECULAR GENETICS. 20:4395-4410.Full Text via DOI: 10.1093/hmg/ddr366 PMID: 21865299
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2011Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines. JOURNAL OF GENERAL VIROLOGY. 92:2356-2366.Full Text via DOI: 10.1099/vir.0.031518-0 PMID: 21697344
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2011Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E. JOURNAL OF VIROLOGY. 85:9425-9436.Full Text via DOI: 10.1128/JVI.05178-11 PMID: 21734044
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2011Improved signal processing and normalization for biomarker protein detection in broad-mass-range TOF mass spectra from clinical samples. PROTEOMICS CLINICAL APPLICATIONS. 5:440-447.Full Text via DOI: 10.1002/prca.201000095 PMID: 21751409
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2011On-tissue identification of insulin: In situ reduction coupled with mass spectrometry imaging. PROTEOMICS CLINICAL APPLICATIONS. 5:448-453.Full Text via DOI: 10.1002/prca.201000152 PMID: 21656913
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2011MALDI tissue imaging: from biomarker discovery to clinical applications. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 17-27.Full Text via DOI: 10.1007/s00216-011-5003-6 PMID: 21541816
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2011Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 10.Full Text via DOI: 10.1074/mcp.M110.007294 PMID: 21447706
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2011Challenges to Developing Proteomic-Based Breast Cancer Diagnostics. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY. 251-259.Full Text via DOI: 10.1089/omi.2010.0120 PMID: 21332380
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2011
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2011A proteomic study of TAR-RNA binding protein (TRBP)-associated factors. CELL AND BIOSCIENCE. 1.Full Text via DOI: 10.1186/2045-3701-1-9 PMID: 21711701
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2011Enhancement in MALDI-TOF MS analysis of the low molecular weight human serum proteome. JOURNAL OF MASS SPECTROMETRY. 85-89.Full Text via DOI: 10.1002/jms.1864 PMID: 21190259
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2011Molecular pathology of prostate cancer. CANCER BIOMARKERS. 9:441-459.Full Text via DOI: 10.3233/CBM-2011-0181 PMID: 22112489
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2011Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen. CHEMICAL COMMUNICATIONS. 47:10338-10340.Full Text via DOI: 10.1039/c1cc11814e PMID: 21853197
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2011High Serum Levels of DNMT1 and Distant Failure in Head and Neck Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S530-S530.Full Text via DOI: 10.1016/j.ijrobp.2011.06.821
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2010Investigation of Sialylation Aberration in N-linked Glycopeptides By Lectin and Tandem Labeling (LTL) Quantitative Proteomics. ANALYTICAL CHEMISTRY. 82:9201-9210.Full Text via DOI: 10.1021/ac101486d PMID: 20923142
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2010Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:33348-33357.Full Text via DOI: 10.1074/jbc.M110.149609 PMID: 20713355
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2010The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:32897-32905.Full Text via DOI: 10.1074/jbc.M110.146373 PMID: 20729195
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2010In-Depth Proteomic Analyses of Direct Expressed Prostatic Secretions. JOURNAL OF PROTEOME RESEARCH. 9:2109-2116.Full Text via DOI: 10.1021/pr1001498 PMID: 20334419
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2010Interaction Domains of the UL16 and UL21 Tegument Proteins of Herpes Simplex Virus. JOURNAL OF VIROLOGY. 84:2963-2971.Full Text via DOI: 10.1128/JVI.02015-09 PMID: 20042500
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2010Adjacent Slice Prostate Cancer Prediction to Inform MALDI Imaging Biomarker Analyses. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.844403
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2010Application of Proteomics to HTLV-1: Understanding Pathogenesis and Enhancing Diagnostics. Recent Advances in Human Retroviruses. Ed. Jeang, K T. WORLD SCIENTIFIC.
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2010Prostate Cancer Region Prediction using MALDI Mass Spectra. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.Full Text via DOI: 10.1117/12.844494
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2010A Bayesian network approach to feature selection in mass spectrometry data. BMC Bioinformatics. 11:177.Full Text via DOI: 10.1186/1471-2105-11-177 PMID: 20377906
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2010Purification of FANCD2 sub-complexes. British Journal of Haematology. 150:no-no.Full Text via DOI: 10.1111/j.1365-2141.2010.08217.x PMID: 20456353
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2010Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine. 2:46ps42-46ps42.Full Text via DOI: 10.1126/scitranslmed.3001249 PMID: 20739680
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2009Phosphorylation regulates human T-cell leukemia virus type 1 Rex function. RETROVIROLOGY. 6.Full Text via DOI: 10.1186/1742-4690-6-105 PMID: 19919707
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2009Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo. AIDS RESEARCH AND HUMAN RETROVIRUSES. 1226-1227.
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2009Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue. CLINICAL CANCER RESEARCH. 15:5541-5551.Full Text via DOI: 10.1158/1078-0432.CCR-08-2892 PMID: 19690195
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2009Proteomic Expression Profiling and Identification of Serum Proteins Using Immobilized Trypsin Beads with MALDI-TOF/TOF. JOURNAL OF PROTEOME RESEARCH. 8:4182-4192.Full Text via DOI: 10.1021/pr800836c PMID: 19603828
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2009Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo. JOURNAL OF VIROLOGY. 83:8859-8868.Full Text via DOI: 10.1128/JVI.00908-09 PMID: 19553333
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2009Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. JOURNAL OF PROTEOMICS. 72:907-917.Full Text via DOI: 10.1016/j.jprot.2009.01.007 PMID: 19457353
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2009Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization. JOURNAL OF VIROLOGY. 83:5339-5352.Full Text via DOI: 10.1128/JVI.00232-09 PMID: 19321601
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2009Serum Proteomic Biomarker Discovery Reflective of Stage and Obesity in Breast Cancer Patients. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 208:970-978.Full Text via DOI: 10.1016/j.jamcollsurg.2008.12.024 PMID: 19476873
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2009Glycomic Characterization of Prostate-Specific Antigen and Prostatic Acid Phosphatase in Prostate Cancer and Benign Disease Seminal Plasma Fluids. JOURNAL OF PROTEOME RESEARCH. 8:620-630.Full Text via DOI: 10.1021/pr8007545 PMID: 19128049
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2009Proteomic Profile as a Prognostic Factor of Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S402-S403.
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2008HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:36311-36320.Full Text via DOI: 10.1074/jbc.M804931200 PMID: 18957425
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2008Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1). JOURNAL OF BIOLOGICAL CHEMISTRY. 283:35834-35844.Full Text via DOI: 10.1074/jbc.M804967200 PMID: 18922800
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2008Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome. RETROVIROLOGY. 5.Full Text via DOI: 10.1186/1742-4690-5-92 PMID: 18922151
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2008Serum protein expression profiling in pediatric Hodgkin lymphoma: A report from the Children's Oncology Group. PEDIATRIC BLOOD & CANCER. 51:216-221.Full Text via DOI: 10.1002/pbc.21581 PMID: 18421715
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2008Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b. JOURNAL OF INFECTIOUS DISEASES. 198:125-133.Full Text via DOI: 10.1086/588825 PMID: 18544012
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2008Nuclear trafficking of the human cytomegalovirus pp71 (ppUL82) tegument protein. VIROLOGY. 376:42-52.Full Text via DOI: 10.1016/j.virol.2008.03.007 PMID: 18423509
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2008Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment. PROTEOMICS. 8:1530-1538.Full Text via DOI: 10.1002/pmic.200701146 PMID: 18340636
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2008A prevalidation study for the evaluation of serum biomarkers of Barrett's esophagus and esophageal adenocarcinoma. CANCER BIOMARKERS. 138-139.
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2008Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: Sources of sample bias. CLINICAL CHEMISTRY. 54:44-52.Full Text via DOI: 10.1373/clinchem.2007.091470 PMID: 17981926
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2008Applications of imaging mass spectrometry to clinical diagnosis. CANCER BIOMARKERS. 181-181.
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2008Differential Capture of Serum Proteins for Expression Profiling and Biomarker Discovery in Pre- and Posttreatment Head and Neck Cancer Samples. LARYNGOSCOPE. 118:61-68.Full Text via DOI: 10.1097/MLG.0b013e31814cf389 PMID: 18043497
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2008
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2008SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer. CLINICAL CHEMISTRY. 54:53-60.Full Text via DOI: 10.1373/clinchem.2007.091496 PMID: 18024530
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2008Signal detection in high-resolution mass spectrometry data. JOURNAL OF PROTEOME RESEARCH. 7:276-285.Full Text via DOI: 10.1021/pr700640a PMID: 18173224
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2008Human T-Cell Leukemia Virus I Tax Protein Sensitizes p53-Mutant Cells to DNA Damage. CANCER RESEARCH. 68:4843-4852.Full Text via DOI: 10.1158/0008-5472.can-07-5070 PMID: 18559532
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2008MALDI/SELDI Protein Profiling of Serum for the Identification of Cancer Biomarkers. Methods in Molecular Biology™. 125-140.Full Text via DOI: 10.1007/978-1-59745-117-8_7
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2008MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers.. ESTROGEN RECEPTORS: METHODS AND PROTOCOLS. 428:125-40.Full Text via DOI: 10.1007/978-1-59745-117-8_7 PMID: 18287771
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2008National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in clinical practice: quality requirements.. CLINICAL CHEMISTRY. 54:e1-e10.Full Text via DOI: 10.1373/clinchem.2007.094144 PMID: 18606634
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2008Tissue Sample Collection for Proteomics Analysis. Methods in Molecular Biology™. 43-53.Full Text via DOI: 10.1007/978-1-59745-117-8_3
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2008Tissue sample collection for proteomics analysis.. ESTROGEN RECEPTORS: METHODS AND PROTOCOLS. 428:43-53.Full Text via DOI: 10.1007/978-1-59745-117-8_3 PMID: 18287767
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2007Proteomic and fractal analysis of a phenotypic transition in the growth of human breast cells in culture. JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT.Full Text via DOI: 10.1088/1742-5468/2007/12/P12006
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2007Human T-cell leukemia virus type 1 tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:29431-29440.Full Text via DOI: 10.1074/jbc.M704110200 PMID: 17698850
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2007SELDI protein profiling of dunning R-3327 derived cell lines: Identification of molecular markers of prostate cancer progression. PROSTATE. 67:1565-1575.Full Text via DOI: 10.1002/pros.20646 PMID: 17705230
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2007Mining the low molecular weight proteome of blood. PROTEOMICS CLINICAL APPLICATIONS. 758-768.Full Text via DOI: 10.1002/prca.200700175 PMID: 21136732
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2007Serum biomarkers to differentiate benign and malignant mammographic lesions. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 204:1065-1071.Full Text via DOI: 10.1016/j.jamcollsurg.2007.01.036 PMID: 17481542
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2007HTLV-1 tax disrupts the cellular DNA damage response via binding and sequestration of active DNA-PK. AIDS RESEARCH AND HUMAN RETROVIRUSES. 590-590.
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2007Automated peak identification in TOF-MS spectra. Quantitative Medical Data Analysis. Ed. Hong, D. WORLD SCIENTIFIC.
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2007Clinical proteomics: A need to define the field and to begin to set adequate standards. PROTEOMICS CLINICAL APPLICATIONS. 1:148-156.Full Text via DOI: 10.1002/prca.200600771 PMID: 21136664
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2007Optimization of MALDI-TOF MS Detection for Enhanced Sensitivity of Affinity-Captured Proteins Spanning a 100 kDa Mass Range. JOURNAL OF PROTEOME RESEARCH. 6:4517-4524.Full Text via DOI: 10.1021/pr0703526 PMID: 17918874
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2006Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:31705-31712.Full Text via DOI: 10.1074/jbc.M607011200 PMID: 16923801
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2006Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. MOLECULAR & CELLULAR PROTEOMICS. 5:1957-1967.Full Text via DOI: 10.1074/mcp.M600176-MCP200 PMID: 16760258
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2006Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. MOLECULAR & CELLULAR PROTEOMICS. S45-S45.
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2006Application of mass spectrometry to the discovery of biomarkers for detection of prostate cancer. JOURNAL OF CELLULAR BIOCHEMISTRY. 98:496-503.Full Text via DOI: 10.1002/jcb.20855 PMID: 16552720
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2006Adult T cell leukemia: a tale of two T cells. JOURNAL OF CLINICAL INVESTIGATION. 858-860.Full Text via DOI: 10.1172/JCI28140 PMID: 16585953
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2006Feature extraction in the analysis of proteomic mass spectra. PROTEOMICS. 6:2095-2100.Full Text via DOI: 10.1002/pmic.200500459 PMID: 16502467
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2006Overexpression of alpha-defensin is associated with bladder cancer invasiveness. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 24:97-108.Full Text via DOI: 10.1016/j.urolonc.2005.07.010 PMID: 16520271
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2006Correlation of breast cancer protein & gene expression profiles with ER status. ANNALS OF SURGICAL ONCOLOGY. 17-17.
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2006Deconvolution filters to enhance resolution of dense time-of-flight survey spectra in the time-lag optimization range. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 20:1661-1669.Full Text via DOI: 10.1002/rcm.2487 PMID: 16636999
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2006Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. CANCER CELL INTERNATIONAL. 6.Full Text via DOI: 10.1186/1475-2867-6-13 PMID: 16670018
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2006Resampling and deconvolution of linear time-of-flight records for enhanced protein profiling. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 20:1670-1678.Full Text via DOI: 10.1002/rcm.2496 PMID: 16637003
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2006PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo. BLOOD. 107:1980-1988.Full Text via DOI: 10.1182/blood-2005-03-1333 PMID: 16263794
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2005Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. ONCOGENE. 5986-5995.Full Text via DOI: 10.1038/sj.onc.1208976 PMID: 16155605
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2005The "omics" haystack: Defining sources of sample bias in expression profiling. CLINICAL CHEMISTRY. 1571-1572.Full Text via DOI: 10.1373/clinchem.2005.053405 PMID: 16120944
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2005Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: Multi-institution correlation of spectra and identification of biomarkers. PROTEOMICS. 5:3467-3474.Full Text via DOI: 10.1002/pmic.200401320 PMID: 16052624
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2005Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease. LEUKEMIA. 19:1229-1238.Full Text via DOI: 10.1038/sj.leu.2403781 PMID: 15889159
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2005The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) tax and represses HTLV-1 long terminal repeat-mediated transcription. JOURNAL OF VIROLOGY. 79:6932-6939.Full Text via DOI: 10.1128/JVI.79.11.6932-6939.2005 PMID: 15890932
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2005Racial disparities in protein profiles of breast cancer ductal epithelial cells/sera. ANNALS OF SURGICAL ONCOLOGY. S49-S49.
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2005Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer. CLINICAL CANCER RESEARCH. 11:1073-1085.
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2005Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. CLINICAL CHEMISTRY. 51:102-112.Full Text via DOI: 10.1373/clinchem.2004.038950 PMID: 15613711
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2005SELDI-TOF Profiling for Clinical Diagnostic Assay Development. Genome and Proteome in Oncology. Ed. Stathopoulou, F T. Nova Science Publishers.
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2005Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 93-100.Full Text via DOI: 10.1586/14737159.5.1.93 PMID: 15723595
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2005Statistical design and analytical strategies for discovery of disease-specific protein patterns. Informatics in Proteomics. Ed. Srivastava, S. Marcel Dekker.
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2005Use of high throughput mass spectrographic methods to identify disease processes. Molecular Diagnostics. Ed. Ansorg, W. Academic Press.
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2005A novel approach for clustering proteomics data using Bayesian fast Fourier transform. Bioinformatics. 21:2210-2224.Full Text via DOI: 10.1093/bioinformatics/bti383 PMID: 15769836
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2005Enhancement of Sensitivity and Resolution of Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Records for Serum Peptides Using Time-Series Analysis Techniques. CLINICAL CHEMISTRY. 51:65-74.Full Text via DOI: 10.1373/clinchem.2004.037283 PMID: 15550476
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2005Functional Clustering Algorithm for High-Dimensional Proteomics Data. Journal of Biomedicine and Biotechnology. 2005:80-86.Full Text via DOI: 10.1155/jbb.2005.80 PMID: 16046812
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2005SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. HEPATOLOGY. 41:634-642.Full Text via DOI: 10.1002/hep.20577 PMID: 15726646
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2005Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer.. CLINICAL CANCER RESEARCH. 11:1073-85.PMID: 15709174
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2005The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription. JOURNAL OF VIROLOGY. 79:6932-6939.Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932
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2005The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.. JOURNAL OF VIROLOGY. 79:6932-9.Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932
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2005The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.. JOURNAL OF VIROLOGY. 79:6932-9.Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932
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2005the need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.. CANCER INFORMATICS. 86-97.PMID: 19305634
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2004Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. PROTEOMICS. 4:826-838.Full Text via DOI: 10.1002/pmic.200300625 PMID: 14997503
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2004Computational protein biomarker prediction: a case study for prostate cancer. BMC Bioinformatics. 5:26.Full Text via DOI: 10.1186/1471-2105-5-26 PMID: 15113409
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2004Defining the role of mass spectrometry in cancer diagnostics.. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 13:1555-7.PMID: 15466969
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2004EXPRESSION OF GENES AND PROTEINS SPECIFIC FOR PROSTATE CANCER. JOURNAL OF UROLOGY. S23.Full Text via DOI: 10.1097/01.ju.0000141781.70474.48 PMID: 15535438
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2004Ga+ TOF-SIMS lineshape analysis for resolution enhancement of MALDI MS spectra of a peptide mixture. Applied Surface Science. 231-232:357-361.Full Text via DOI: 10.1016/j.apsusc.2004.03.097
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2004Identification of Patients With Head and Neck Cancer Using Serum Protein Profiles. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 130:98-104.Full Text via DOI: 10.1001/archotol.130.1.98 PMID: 14732777
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2004Measurement Reproducibility in the Early Stages of Biomarker Development. Disease Markers. 20:295-307.Full Text via DOI: 10.1155/2004/726517 PMID: 15665389
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2004Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer. 100:1814-1822.Full Text via DOI: 10.1002/cncr.20203 PMID: 15112261
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2004Protein Profiling in Urine for the Diagnosis of Bladder Cancer. CLINICAL CHEMISTRY. 1438-1441.Full Text via DOI: 10.1373/clinchem.2003.028035 PMID: 15277356
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2004Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intactp53. Journal of Biomedicine and Biotechnology. 2004:185-194.Full Text via DOI: 10.1155/s1110724304403131 PMID: 15467158
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2004SELDI-TOF Serum Profiling for Prognostic and Diagnostic Classification of Breast Cancers. Disease Markers. 19:229-238.Full Text via DOI: 10.1155/2004/759530
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2004Serum Protein Expression Profiling for Cancer Detection: Validation of a SELDI-Based Approach for Prostate Cancer. Disease Markers. 19:185-195.Full Text via DOI: 10.1155/2004/546293 PMID: 15258333
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2004Serum Protein Profiles to Identify Head and Neck Cancer. CLINICAL CANCER RESEARCH. 10:1625-1632.Full Text via DOI: 10.1158/1078-0432.ccr-0297-3 PMID: 15014013
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2004Surfaced-Enhanced Laser Desorption/Ionization Time-of-Flight (SELDI-TOF) Differentiation of Serum Protein Profiles of BRCA-1 and Sporadic Breast Cancer. ANNALS OF SURGICAL ONCOLOGY. 11:907-914.Full Text via DOI: 10.1245/aso.2004.03.557 PMID: 15383419
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2004The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 22:337-343.Full Text via DOI: 10.1016/j.urolonc.2004.04.008 PMID: 15283893
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2003A Look at Mass Spectral Measurement. CHANCE. 16:24-28.Full Text via DOI: 10.1080/09332480.2003.10554871
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2003A novel approach toward development of a rapid blood test for breast cancer.. Clinical breast cancer. 4:203-9.Full Text via DOI: 10.3816/cbc.2003.n.026 PMID: 14499014
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2003Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response. The Journal of biological chemistry. 278:37736-37744.Full Text via DOI: 10.1074/jbc.m301649200 PMID: 12842897
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2003Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and Regulation of Tumor Necrosis Factor- Expression. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 95:1846-1859.Full Text via DOI: 10.1093/jnci/djg118 PMID: 14679154
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2003Proteomics in Health and Disease.. Journal of Biomedicine and Biotechnology. 2003:215-216.Full Text via DOI: 10.1155/s1110724303002997 PMID: 14615628
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2003SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers.. Disease Markers. 19:229-38.Full Text via DOI: 10.1155/2004/759530 PMID: 15258337
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2003The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells. VIROLOGY. 305:229-239.Full Text via DOI: 10.1006/viro.2002.1642 PMID: 12573569
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2002
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2002
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2002
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2001Properties of Two EBV Mta Nuclear Export Signal Sequences. VIROLOGY. 288:119-128.Full Text via DOI: 10.1006/viro.2001.1057 PMID: 11543664
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2001Proteomic approaches to biomarker discovery in prostate and bladder cancers.. PROTEOMICS. 1:1264-70.Full Text via DOI: 10.1002/1615-9861(200110)1:10<1264::aid-prot1264>3.0.co;2-r PMID: 11721637
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2000Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets. JOURNAL OF VIROLOGY. 74:2351-2364.Full Text via DOI: 10.1128/jvi.74.5.2351-2364.2000 PMID: 10666266
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1999Development of a Transgenic Mouse Model for HTLV Neurological Disease. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.
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1999HTLV-I Tax and Loss of Genetic Integrity. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.
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1999Stimulation of the G1 to S Phase Transition and T-cell Proliferation by the Tax Protein of HTLV-1. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.
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1999Analysis of potential phosphorylation sites in human T cell leukemia virus type 1 Tax. Journal of Biomedical Science. 6:206-212.Full Text via DOI: 10.1007/bf02255904 PMID: 10343169
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1998A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes. The Journal of biological chemistry. 273:6698-6703.Full Text via DOI: 10.1074/jbc.273.12.6698 PMID: 9506967
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1998Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat. JOURNAL OF VIROLOGY. 2615-2629.Full Text via DOI: 10.1128/jvi.72.4.2615-2629.1998 PMID: 9525578
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1998Mta Has Properties of an RNA Export Protein and Increases Cytoplasmic Accumulation of Epstein-Barr Virus Replication Gene mRNA. JOURNAL OF VIROLOGY. 72:9526-9534.Full Text via DOI: 10.1128/jvi.72.12.9526-9534.1998 PMID: 9811685
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1998The Epstein-Barr Virus Lytic Transactivator Zta Interacts with the Helicase-Primase Replication Proteins. JOURNAL OF VIROLOGY. 72:8559-8567.Full Text via DOI: 10.1128/jvi.72.11.8559-8567.1998 PMID: 9765394
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1997Divergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization. Journal of Biomedical Science. 4:229-234.Full Text via DOI: 10.1007/bf02253422 PMID: 12386384
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1997HTLV-I tax and cytokeratin: Tax-expressing cells show morphological changes in keratin-containing cytoskeletal networks. Journal of Biomedical Science. 4:47-53.Full Text via DOI: 10.1007/bf02255593 PMID: 11725133
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1996HTLV-I and HTLV-II Tax: Differences in Induction of Micronuclei in Cells and Transcriptional Activation of Viral LTRs. VIROLOGY. 217:373-379.Full Text via DOI: 10.1006/viro.1996.0126 PMID: 8599225
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1996Human T-cell Leukemia Virus Type I Tax Masks c-Myc Function through a cAMP-dependent Pathway. The Journal of biological chemistry. 271:9730-9738.Full Text via DOI: 10.1074/jbc.271.16.9730 PMID: 8621651
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1996Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles.. JOURNAL OF VIROLOGY. 70:6347-6357.Full Text via DOI: 10.1128/jvi.70.9.6347-6357.1996 PMID: 8709263
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1995Interaction of Tax with CREB requires intact zinc-finger. JOURNAL OF VIROLOGY.
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1995Proliferation of a murine IL-2-dependent cell line to measure altered Il-2 receptor function induced by tunicamycin and sialidase. Receptor Research Methods. Ed. Greenstein, D. Harwood Academic Publishing.
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1995Definition of a minimal activation domain in human T-cell leukemia virus type I Tax.. JOURNAL OF VIROLOGY. 69:1827-1833.Full Text via DOI: 10.1128/jvi.69.3.1827-1833.1995 PMID: 7853523
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1995The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein.. JOURNAL OF VIROLOGY. 5806-11.PMID: 7637025
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1993Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function. VIROLOGY. 456-459.Full Text via DOI: 10.1006/viro.1993.1145 PMID: 8438579
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1992HTLV-I tax is a zinc-binding protein: Role of zinc in tax structure and function. VIROLOGY. 188:754-764.Full Text via DOI: 10.1016/0042-6822(92)90530-3 PMID: 1585646
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1992Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins.. JOURNAL OF VIROLOGY. 66:7183-7192.Full Text via DOI: 10.1128/jvi.66.12.7183-7192.1992 PMID: 1433511
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1992Tunicamycin inhibits function and expression of the high-affinity IL-2 receptor in a murine IL-2-dependent cell line. International Journal of Immunopharmacology. 14:583-593.Full Text via DOI: 10.1016/0192-0561(92)90119-6 PMID: 1521926
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1990HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. SCIENCE. 247:1082-1084.Full Text via DOI: 10.1126/science.2309119 PMID: 2309119
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1985C-terminal deletion analogs of a crustacean pigment-dispersing hormone. Peptides. 6:1051-1056.Full Text via DOI: 10.1016/0196-9781(85)90427-9 PMID: 3841733
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1985Characterization of a pigment-dispersing hormone in eyestalks of the fiddler crab Uca pugilator. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 82:5319-5322.Full Text via DOI: 10.1073/pnas.82.16.5319 PMID: 16593589
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1985Substitution of norleucine for methionine residues in a crustacean pigment-dispersing hormone. Peptides. 6:491-494.Full Text via DOI: 10.1016/0196-9781(85)90115-9 PMID: 3840888
editor of
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Book Chapter
- Development of a Transgenic Mouse Model for HTLV Neurological Disease. Molecular Pathogenesis of HTLV: A Current Perspective. Vandemere Press. 1999
- HTLV-I Tax and Loss of Genetic Integrity. Molecular Pathogenesis of HTLV: A Current Perspective. Vandemere Press. 1999
- Stimulation of the G1 to S Phase Transition and T-cell Proliferation by the Tax Protein of HTLV-1. Molecular Pathogenesis of HTLV: A Current Perspective. Vandemere Press. 1999
Contact
preferred title
- Anthem Distinguished Professor, Associate Dean For Translational Research, Director Leroy T Canoles Jr Cancer Research Center
full name
- O. John Semmes, PhD, MS
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- Biochemistry & Molecular Biology
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