Semmes, IV, O. John

2021

NF-kappa B-induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 118.

Full Text via DOI: 10.1073/pnas.2005568118 PMID: 33649200

2020

Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination. PROTEOMICS CLINICAL APPLICATIONS.

Full Text via DOI: 10.1002/prca.202000012 PMID: 32614141

2020

Correction: The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1.. PLOS PATHOGENS. 16:e1009135.

Full Text via DOI: 10.1371/journal.ppat.1009135 PMID: 33306747

2020

Prostate Cancer Biomarker Development: National Cancer Institute's Early Detection Research Network Prostate Cancer Collaborative Group Review.. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 29:2454-2462.

Full Text via DOI: 10.1158/1055-9965.epi-20-1104 PMID: 33093161

2020

RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia.. PLOS PATHOGENS. 16:e1008618.

Full Text via DOI: 10.1371/journal.ppat.1008618 PMID: 32453758

2019

Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 39:2168-2191.

Full Text via DOI: 10.1161/ATVBAHA.119.312826 PMID: 31434495

2018

A Lipidomics Approach to Identifying Key Lipid Species Involved in VEGF-Inhibitor Mediated Attenuation of Bleomycin-Induced Pulmonary Fibrosis. PROTEOMICS CLINICAL APPLICATIONS. 12.

Full Text via DOI: 10.1002/prca.201700086 PMID: 29283216

2018

Characterization and Evidence of the miR-888 Cluster as a Novel Cancer Network in Prostate. MOLECULAR CANCER RESEARCH. 16:669-681.

Full Text via DOI: 10.1158/1541-7786.MCR-17-0321 PMID: 29330297

2017

Changes in the Hippocampal Proteome Associated with Spatial Memory Impairment after Exposure to Low (20 cGy) Doses of 1 GeV/ n Fe-56 Radiation. RADIATION RESEARCH. 187:287-297.

Full Text via DOI: 10.1667/RR14067.1 PMID: 28156212

2016

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. VIRUSES-BASEL.

Full Text via DOI: 10.3390/v8060161 PMID: 27322308

2016

Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. NATURE COMMUNICATIONS. 7.

Full Text via DOI: 10.1038/ncomms11906 PMID: 27350604

2016

A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis. PROTEOMICS. 16:33-46.

Full Text via DOI: 10.1002/pmic.201500171 PMID: 26425798

2016

Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. JOURNAL OF CELLULAR PHYSIOLOGY. 231:1364-1374.

Full Text via DOI: 10.1002/jcp.25240 PMID: 26530043

2015

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.

2015

Circulating exosomes as an enriched source for adult T-cell leukemia biomarkers. RETROVIROLOGY.

2015

Insight into the biogenesis of tax nuclear speckles using comparative interactome analysis. RETROVIROLOGY.

2015

From profiling to function: A role for microRNA miR-888 in promoting prostate cancer progression. CANCER RESEARCH.

Full Text via DOI: 10.1158/1538-7445.AM2015-3086

2015

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. PLOS PATHOGENS. 11.

Full Text via DOI: 10.1371/journal.ppat.1005102 PMID: 26285145

2015

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. ONCOTARGET. 6:43743-43758.

Full Text via DOI: 10.18632/oncotarget.6193 PMID: 26497208

2015

Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort. EUROPEAN JOURNAL OF NEUROLOGY. 22:591-599.

Full Text via DOI: 10.1111/ene.12534 PMID: 25104396

2014

The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1. PLOS PATHOGENS. 10.

Full Text via DOI: 10.1371/journal.ppat.1004343 PMID: 25211330

2014

Histone Deacetylase Inhibitors Potentiate Vesicular Stomatitis Virus Oncolysis in Prostate Cancer Cells by Modulating NF-kappa B-Dependent Autophagy. JOURNAL OF VIROLOGY. 88:2927-2940.

Full Text via DOI: 10.1128/JVI.03406-13 PMID: 24371063

2014

miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. CELL CYCLE. 13:227-239.

Full Text via DOI: 10.4161/cc.26984 PMID: 24200968

2014

MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma. Oncoscience. 1:725.

Full Text via DOI: 10.18632/oncoscience.99

2014

MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma.

Full Text via DOI: 10.18632/oncoscience.99 PMID: 25593999

2013

Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1. JOURNAL OF VIROLOGY. 87:11516-11524.

Full Text via DOI: 10.1128/JVI.01642-13 PMID: 23966382

2013

Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. PROTEOMICS CLINICAL APPLICATIONS. 7:677-689.

Full Text via DOI: 10.1002/prca.201200134 PMID: 23775902

2013

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. PROTEOMICS. 13:1667-1671.

Full Text via DOI: 10.1002/pmic.201200561 PMID: 23533145

2013

The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach. MOLECULAR HUMAN REPRODUCTION. 19:250-263.

Full Text via DOI: 10.1093/molehr/gas063 PMID: 23247814

2013

Focus on cancer proteomics.. PROTEOMICS CLINICAL APPLICATIONS. 7:315.

Full Text via DOI: 10.1002/prca.201370034 PMID: 23780814

2013

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription. JOURNAL OF VIROLOGY. 87:4360-4371.

Full Text via DOI: 10.1128/jvi.02574-12 PMID: 23388725

2012

Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 11:1870-1884.

Full Text via DOI: 10.1074/mcp.M112.017889 PMID: 22986220

2012

NADiA ProsVue Prostate-specific Antigen Slope Is an Independent Prognostic Marker for Identifying Men at Reduced Risk of Clinical Recurrence of Prostate Cancer After Radical Prostatectomy. UROLOGY. 80:1319-1325.

Full Text via DOI: 10.1016/j.urology.2012.06.080 PMID: 23107099

2012

Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. CARCINOGENESIS. 33:2208-2219.

Full Text via DOI: 10.1093/carcin/bgs213 PMID: 22782996

2012

BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:9575-9580.

Full Text via DOI: 10.1073/pnas.1207496109 PMID: 22645331

2012

Post-prostatectomy PSA slope (ProsVue) in Gleason score >= 7 disease. JOURNAL OF CLINICAL ONCOLOGY.

2012

Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine. JOURNAL OF PROTEOME RESEARCH. 11:2386-2396.

Full Text via DOI: 10.1021/pr2011236 PMID: 22339264

2012

The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax. BLOOD. 119:1173-1181.

Full Text via DOI: 10.1182/blood-2011-06-358564 PMID: 22106342

2012

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY. 84:141-148.

Full Text via DOI: 10.1021/ac2021322 PMID: 22098105

2012

Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management. Principles of Molecular Diagnostics and Personalized Cancer Medicine. Ed. Lynch, H. Lippincott, Williams & Wilkins.

2011

Functional and physical interaction between the mismatch repair and FA-BRCA pathways. HUMAN MOLECULAR GENETICS. 20:4395-4410.

Full Text via DOI: 10.1093/hmg/ddr366 PMID: 21865299

2011

Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines. JOURNAL OF GENERAL VIROLOGY. 92:2356-2366.

Full Text via DOI: 10.1099/vir.0.031518-0 PMID: 21697344

2011

Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E. JOURNAL OF VIROLOGY. 85:9425-9436.

Full Text via DOI: 10.1128/JVI.05178-11 PMID: 21734044

2011

Improved signal processing and normalization for biomarker protein detection in broad-mass-range TOF mass spectra from clinical samples. PROTEOMICS CLINICAL APPLICATIONS. 5:440-447.

Full Text via DOI: 10.1002/prca.201000095 PMID: 21751409

2011

On-tissue identification of insulin: In situ reduction coupled with mass spectrometry imaging. PROTEOMICS CLINICAL APPLICATIONS. 5:448-453.

Full Text via DOI: 10.1002/prca.201000152 PMID: 21656913

2011

MALDI tissue imaging: from biomarker discovery to clinical applications. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 17-27.

Full Text via DOI: 10.1007/s00216-011-5003-6 PMID: 21541816

2011

Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer. MOLECULAR & CELLULAR PROTEOMICS. 10.

Full Text via DOI: 10.1074/mcp.M110.007294 PMID: 21447706

2011

Challenges to Developing Proteomic-Based Breast Cancer Diagnostics. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY. 251-259.

Full Text via DOI: 10.1089/omi.2010.0120 PMID: 21332380

2011

Proteomic analysis reveals a network of inflammatory genes in epidermis associated with skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. CANCER RESEARCH.

Full Text via DOI: 10.1158/1538-7445.AM2011-2729

2011

Prognostic impact of post-prostatectomy PSA slope determined with a novel nucleic acid detection immunoassay (NADIA ProsVue) for total PSA. JOURNAL OF CLINICAL ONCOLOGY.

2011

A proteomic study of TAR-RNA binding protein (TRBP)-associated factors. CELL AND BIOSCIENCE. 1.

Full Text via DOI: 10.1186/2045-3701-1-9 PMID: 21711701

2011

Enhancement in MALDI-TOF MS analysis of the low molecular weight human serum proteome. JOURNAL OF MASS SPECTROMETRY. 85-89.

Full Text via DOI: 10.1002/jms.1864 PMID: 21190259

2011

Molecular pathology of prostate cancer. CANCER BIOMARKERS. 9:441-459.

Full Text via DOI: 10.3233/CBM-2011-0181 PMID: 22112489

2011

Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen. CHEMICAL COMMUNICATIONS. 47:10338-10340.

Full Text via DOI: 10.1039/c1cc11814e PMID: 21853197

2011

High Serum Levels of DNMT1 and Distant Failure in Head and Neck Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S530-S530.

Full Text via DOI: 10.1016/j.ijrobp.2011.06.821

2010

Investigation of Sialylation Aberration in N-linked Glycopeptides By Lectin and Tandem Labeling (LTL) Quantitative Proteomics. ANALYTICAL CHEMISTRY. 82:9201-9210.

Full Text via DOI: 10.1021/ac101486d PMID: 20923142

2010

Structural Characterization of Prostatic Glycopeptides using Triple Quadrupole Mass Spectrometry Approaches Coupled with Simglycan Analysis Software. GLYCOBIOLOGY. 1491-1491.

2010

Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:33348-33357.

Full Text via DOI: 10.1074/jbc.M110.149609 PMID: 20713355

2010

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:32897-32905.

Full Text via DOI: 10.1074/jbc.M110.146373 PMID: 20729195

2010

In-Depth Proteomic Analyses of Direct Expressed Prostatic Secretions. JOURNAL OF PROTEOME RESEARCH. 9:2109-2116.

Full Text via DOI: 10.1021/pr1001498 PMID: 20334419

2010

Interaction Domains of the UL16 and UL21 Tegument Proteins of Herpes Simplex Virus. JOURNAL OF VIROLOGY. 84:2963-2971.

Full Text via DOI: 10.1128/JVI.02015-09 PMID: 20042500

2010

Adjacent Slice Prostate Cancer Prediction to Inform MALDI Imaging Biomarker Analyses. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.

Full Text via DOI: 10.1117/12.844403

2010

Application of Proteomics to HTLV-1: Understanding Pathogenesis and Enhancing Diagnostics. Recent Advances in Human Retroviruses. Ed. Jeang, K T. WORLD SCIENTIFIC.

2010

Prostate Cancer Region Prediction using MALDI Mass Spectra. MEDICAL IMAGING 2010: COMPUTER - AIDED DIAGNOSIS.

Full Text via DOI: 10.1117/12.844494

2010

A Bayesian network approach to feature selection in mass spectrometry data. BMC Bioinformatics. 11:177.

Full Text via DOI: 10.1186/1471-2105-11-177 PMID: 20377906

2010

Purification of FANCD2 sub-complexes. British Journal of Haematology. 150:no-no.

Full Text via DOI: 10.1111/j.1365-2141.2010.08217.x PMID: 20456353

2010

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine. 2:46ps42-46ps42.

Full Text via DOI: 10.1126/scitranslmed.3001249 PMID: 20739680

2009

Phosphorylation regulates human T-cell leukemia virus type 1 Rex function. RETROVIROLOGY. 6.

Full Text via DOI: 10.1186/1742-4690-6-105 PMID: 19919707

2009

Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo. AIDS RESEARCH AND HUMAN RETROVIRUSES. 1226-1227.

2009

Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue. CLINICAL CANCER RESEARCH. 15:5541-5551.

Full Text via DOI: 10.1158/1078-0432.CCR-08-2892 PMID: 19690195

2009

Proteomic Expression Profiling and Identification of Serum Proteins Using Immobilized Trypsin Beads with MALDI-TOF/TOF. JOURNAL OF PROTEOME RESEARCH. 8:4182-4192.

Full Text via DOI: 10.1021/pr800836c PMID: 19603828

2009

Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo. JOURNAL OF VIROLOGY. 83:8859-8868.

Full Text via DOI: 10.1128/JVI.00908-09 PMID: 19553333

2009

Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. JOURNAL OF PROTEOMICS. 72:907-917.

Full Text via DOI: 10.1016/j.jprot.2009.01.007 PMID: 19457353

2009

Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization. JOURNAL OF VIROLOGY. 83:5339-5352.

Full Text via DOI: 10.1128/JVI.00232-09 PMID: 19321601

2009

Expressed prostatic secretions in urine and directly collected prostatic fluids as enriched sources of prostate cancer protein biomarkers. CANCER RESEARCH.

2009

Serum Proteomic Biomarker Discovery Reflective of Stage and Obesity in Breast Cancer Patients. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 208:970-978.

Full Text via DOI: 10.1016/j.jamcollsurg.2008.12.024 PMID: 19476873

2009

Glycomic Characterization of Prostate-Specific Antigen and Prostatic Acid Phosphatase in Prostate Cancer and Benign Disease Seminal Plasma Fluids. JOURNAL OF PROTEOME RESEARCH. 8:620-630.

Full Text via DOI: 10.1021/pr8007545 PMID: 19128049

2009

Proteomic Profile as a Prognostic Factor of Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. S402-S403.

2008

HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:36311-36320.

Full Text via DOI: 10.1074/jbc.M804931200 PMID: 18957425

2008

Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1). JOURNAL OF BIOLOGICAL CHEMISTRY. 283:35834-35844.

Full Text via DOI: 10.1074/jbc.M804967200 PMID: 18922800

2008

Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome. RETROVIROLOGY. 5.

Full Text via DOI: 10.1186/1742-4690-5-92 PMID: 18922151

2008

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Clinical Practice: Quality Requirements. CLINICAL CHEMISTRY. 54:E1-E10.

2008

Serum protein expression profiling in pediatric Hodgkin lymphoma: A report from the Children's Oncology Group. PEDIATRIC BLOOD & CANCER. 51:216-221.

Full Text via DOI: 10.1002/pbc.21581 PMID: 18421715

2008

Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b. JOURNAL OF INFECTIOUS DISEASES. 198:125-133.

Full Text via DOI: 10.1086/588825 PMID: 18544012

2008

Nuclear trafficking of the human cytomegalovirus pp71 (ppUL82) tegument protein. VIROLOGY. 376:42-52.

Full Text via DOI: 10.1016/j.virol.2008.03.007 PMID: 18423509

2008

Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment. PROTEOMICS. 8:1530-1538.

Full Text via DOI: 10.1002/pmic.200701146 PMID: 18340636

2008

A prevalidation study for the evaluation of serum biomarkers of Barrett's esophagus and esophageal adenocarcinoma. CANCER BIOMARKERS. 138-139.

2008

A sequential fractionation workflow with immobilized trypsin paramagnetic beads for expression profiling and identification of serum proteins by LIFT-MALDI-TOF/TOF. CANCER BIOMARKERS. 170-171.

2008

Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: Sources of sample bias. CLINICAL CHEMISTRY. 54:44-52.

Full Text via DOI: 10.1373/clinchem.2007.091470 PMID: 17981926

2008

Applications of imaging mass spectrometry to clinical diagnosis. CANCER BIOMARKERS. 181-181.

2008

Differential Capture of Serum Proteins for Expression Profiling and Biomarker Discovery in Pre- and Posttreatment Head and Neck Cancer Samples. LARYNGOSCOPE. 118:61-68.

Full Text via DOI: 10.1097/MLG.0b013e31814cf389 PMID: 18043497

2008

Expressed prostatic secretion (EPS) collection for proteome characterization as an enriched source of prostatic disease biomarkers. CANCER BIOMARKERS. 139-139.

2008

SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer. CLINICAL CHEMISTRY. 54:53-60.

Full Text via DOI: 10.1373/clinchem.2007.091496 PMID: 18024530

2008

Signal detection in high-resolution mass spectrometry data. JOURNAL OF PROTEOME RESEARCH. 7:276-285.

Full Text via DOI: 10.1021/pr700640a PMID: 18173224

2008

Human T-Cell Leukemia Virus I Tax Protein Sensitizes p53-Mutant Cells to DNA Damage. CANCER RESEARCH. 68:4843-4852.

Full Text via DOI: 10.1158/0008-5472.can-07-5070 PMID: 18559532

2008

MALDI/SELDI Protein Profiling of Serum for the Identification of Cancer Biomarkers. Methods in Molecular Biology™. 125-140.

Full Text via DOI: 10.1007/978-1-59745-117-8_7

2008

MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers.. ESTROGEN RECEPTORS: METHODS AND PROTOCOLS. 428:125-40.

Full Text via DOI: 10.1007/978-1-59745-117-8_7 PMID: 18287771

2008

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in clinical practice: quality requirements.. CLINICAL CHEMISTRY. 54:e1-e10.

Full Text via DOI: 10.1373/clinchem.2007.094144 PMID: 18606634

2008

Tissue Sample Collection for Proteomics Analysis. Methods in Molecular Biology™. 43-53.

Full Text via DOI: 10.1007/978-1-59745-117-8_3

2008

Tissue sample collection for proteomics analysis.. ESTROGEN RECEPTORS: METHODS AND PROTOCOLS. 428:43-53.

Full Text via DOI: 10.1007/978-1-59745-117-8_3 PMID: 18287767

2007

Proteomic and fractal analysis of a phenotypic transition in the growth of human breast cells in culture. JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT.

Full Text via DOI: 10.1088/1742-5468/2007/12/P12006

2007

Human T-cell leukemia virus type 1 tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:29431-29440.

Full Text via DOI: 10.1074/jbc.M704110200 PMID: 17698850

2007

SELDI protein profiling of dunning R-3327 derived cell lines: Identification of molecular markers of prostate cancer progression. PROSTATE. 67:1565-1575.

Full Text via DOI: 10.1002/pros.20646 PMID: 17705230

2007

Mining the low molecular weight proteome of blood. PROTEOMICS CLINICAL APPLICATIONS. 758-768.

Full Text via DOI: 10.1002/prca.200700175 PMID: 21136732

2007

Serum biomarkers to differentiate benign and malignant mammographic lesions. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 204:1065-1071.

Full Text via DOI: 10.1016/j.jamcollsurg.2007.01.036 PMID: 17481542

2007

HTLV-1 tax disrupts the cellular DNA damage response via binding and sequestration of active DNA-PK. AIDS RESEARCH AND HUMAN RETROVIRUSES. 590-590.

2007

Automated peak identification in TOF-MS spectra. Quantitative Medical Data Analysis. Ed. Hong, D. WORLD SCIENTIFIC.

2007

Clinical proteomics: A need to define the field and to begin to set adequate standards. PROTEOMICS CLINICAL APPLICATIONS. 1:148-156.

Full Text via DOI: 10.1002/prca.200600771 PMID: 21136664

2007

Optimization of MALDI-TOF MS Detection for Enhanced Sensitivity of Affinity-Captured Proteins Spanning a 100 kDa Mass Range. JOURNAL OF PROTEOME RESEARCH. 6:4517-4524.

Full Text via DOI: 10.1021/pr0703526 PMID: 17918874

2006

Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:31705-31712.

Full Text via DOI: 10.1074/jbc.M607011200 PMID: 16923801

2006

Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. MOLECULAR & CELLULAR PROTEOMICS. 5:1957-1967.

Full Text via DOI: 10.1074/mcp.M600176-MCP200 PMID: 16760258

2006

Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. MOLECULAR & CELLULAR PROTEOMICS. S45-S45.

2006

Application of mass spectrometry to the discovery of biomarkers for detection of prostate cancer. JOURNAL OF CELLULAR BIOCHEMISTRY. 98:496-503.

Full Text via DOI: 10.1002/jcb.20855 PMID: 16552720

2006

Adult T cell leukemia: a tale of two T cells. JOURNAL OF CLINICAL INVESTIGATION. 858-860.

Full Text via DOI: 10.1172/JCI28140 PMID: 16585953

2006

Differential lectin capture profiling and identification of serum glycoproteins to detect and monitor prostate cancer. CANCER RESEARCH.

2006

Feature extraction in the analysis of proteomic mass spectra. PROTEOMICS. 6:2095-2100.

Full Text via DOI: 10.1002/pmic.200500459 PMID: 16502467

2006

Proteomic profiles predict therapy response in patients with squamous cell carcinoma of the head and neck. CANCER RESEARCH.

2006

Overexpression of alpha-defensin is associated with bladder cancer invasiveness. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 24:97-108.

Full Text via DOI: 10.1016/j.urolonc.2005.07.010 PMID: 16520271

2006

Correlation of breast cancer protein & gene expression profiles with ER status. ANNALS OF SURGICAL ONCOLOGY. 17-17.

2006

Deconvolution filters to enhance resolution of dense time-of-flight survey spectra in the time-lag optimization range. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 20:1661-1669.

Full Text via DOI: 10.1002/rcm.2487 PMID: 16636999

2006

Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. CANCER CELL INTERNATIONAL. 6.

Full Text via DOI: 10.1186/1475-2867-6-13 PMID: 16670018

2006

Resampling and deconvolution of linear time-of-flight records for enhanced protein profiling. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 20:1670-1678.

Full Text via DOI: 10.1002/rcm.2496 PMID: 16637003

2006

PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo. BLOOD. 107:1980-1988.

Full Text via DOI: 10.1182/blood-2005-03-1333 PMID: 16263794

2005

Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. ONCOGENE. 5986-5995.

Full Text via DOI: 10.1038/sj.onc.1208976 PMID: 16155605

2005

The "omics" haystack: Defining sources of sample bias in expression profiling. CLINICAL CHEMISTRY. 1571-1572.

Full Text via DOI: 10.1373/clinchem.2005.053405 PMID: 16120944

2005

Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: Multi-institution correlation of spectra and identification of biomarkers. PROTEOMICS. 5:3467-3474.

Full Text via DOI: 10.1002/pmic.200401320 PMID: 16052624

2005

Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease. LEUKEMIA. 19:1229-1238.

Full Text via DOI: 10.1038/sj.leu.2403781 PMID: 15889159

2005

The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) tax and represses HTLV-1 long terminal repeat-mediated transcription. JOURNAL OF VIROLOGY. 79:6932-6939.

Full Text via DOI: 10.1128/JVI.79.11.6932-6939.2005 PMID: 15890932

2005

Racial disparities in protein profiles of breast cancer ductal epithelial cells/sera. ANNALS OF SURGICAL ONCOLOGY. S49-S49.

2005

Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer. CLINICAL CANCER RESEARCH. 11:1073-1085.

2005

Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. CLINICAL CHEMISTRY. 51:102-112.

Full Text via DOI: 10.1373/clinchem.2004.038950 PMID: 15613711

2005

SELDI-TOF Profiling for Clinical Diagnostic Assay Development. Genome and Proteome in Oncology. Ed. Stathopoulou, F T. Nova Science Publishers.

2005

Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 93-100.

Full Text via DOI: 10.1586/14737159.5.1.93 PMID: 15723595

2005

Statistical design and analytical strategies for discovery of disease-specific protein patterns. Informatics in Proteomics. Ed. Srivastava, S. Marcel Dekker.

2005

Use of high throughput mass spectrographic methods to identify disease processes. Molecular Diagnostics. Ed. Ansorg, W. Academic Press.

2005

A novel approach for clustering proteomics data using Bayesian fast Fourier transform. Bioinformatics. 21:2210-2224.

Full Text via DOI: 10.1093/bioinformatics/bti383 PMID: 15769836

2005

Enhancement of Sensitivity and Resolution of Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Records for Serum Peptides Using Time-Series Analysis Techniques. CLINICAL CHEMISTRY. 51:65-74.

Full Text via DOI: 10.1373/clinchem.2004.037283 PMID: 15550476

2005

Functional Clustering Algorithm for High-Dimensional Proteomics Data. Journal of Biomedicine and Biotechnology. 2005:80-86.

Full Text via DOI: 10.1155/jbb.2005.80 PMID: 16046812

2005

SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. HEPATOLOGY. 41:634-642.

Full Text via DOI: 10.1002/hep.20577 PMID: 15726646

2005

Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer.. CLINICAL CANCER RESEARCH. 11:1073-85.

PMID: 15709174

2005

The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription. JOURNAL OF VIROLOGY. 79:6932-6939.

Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932

2005

The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.. JOURNAL OF VIROLOGY. 79:6932-9.

Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932

2005

The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.. JOURNAL OF VIROLOGY. 79:6932-9.

Full Text via DOI: 10.1128/jvi.79.11.6932-6939.2005 PMID: 15890932

2005

the need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis.. CANCER INFORMATICS. 86-97.

PMID: 19305634

2004

Discovery of protein expression differences in prostate basal cells and epithelial cells may be indicative of early transformation. Urologic Oncology.

2004

Urinary protein profiling of bladder cancer patients by decision tree classification of mass spectral data. CLINICAL CHEMISTRY.

2004

Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. PROTEOMICS. 4:826-838.

Full Text via DOI: 10.1002/pmic.200300625 PMID: 14997503

2004

Computational protein biomarker prediction: a case study for prostate cancer. BMC Bioinformatics. 5:26.

Full Text via DOI: 10.1186/1471-2105-5-26 PMID: 15113409

2004

Defining the role of mass spectrometry in cancer diagnostics.. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 13:1555-7.

PMID: 15466969

2004

EXPRESSION OF GENES AND PROTEINS SPECIFIC FOR PROSTATE CANCER. JOURNAL OF UROLOGY. S23.

Full Text via DOI: 10.1097/01.ju.0000141781.70474.48 PMID: 15535438

2004

Ga+ TOF-SIMS lineshape analysis for resolution enhancement of MALDI MS spectra of a peptide mixture. Applied Surface Science. 231-232:357-361.

Full Text via DOI: 10.1016/j.apsusc.2004.03.097

2004

Identification of Patients With Head and Neck Cancer Using Serum Protein Profiles. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 130:98-104.

Full Text via DOI: 10.1001/archotol.130.1.98 PMID: 14732777

2004

Measurement Reproducibility in the Early Stages of Biomarker Development. Disease Markers. 20:295-307.

Full Text via DOI: 10.1155/2004/726517 PMID: 15665389

2004

Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer. 100:1814-1822.

Full Text via DOI: 10.1002/cncr.20203 PMID: 15112261

2004

Protein Profiling in Urine for the Diagnosis of Bladder Cancer. CLINICAL CHEMISTRY. 1438-1441.

Full Text via DOI: 10.1373/clinchem.2003.028035 PMID: 15277356

2004

Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intactp53. Journal of Biomedicine and Biotechnology. 2004:185-194.

Full Text via DOI: 10.1155/s1110724304403131 PMID: 15467158

2004

SELDI-TOF Serum Profiling for Prognostic and Diagnostic Classification of Breast Cancers. Disease Markers. 19:229-238.

Full Text via DOI: 10.1155/2004/759530

2004

Serum Protein Expression Profiling for Cancer Detection: Validation of a SELDI-Based Approach for Prostate Cancer. Disease Markers. 19:185-195.

Full Text via DOI: 10.1155/2004/546293 PMID: 15258333

2004

Serum Protein Profiles to Identify Head and Neck Cancer. CLINICAL CANCER RESEARCH. 10:1625-1632.

Full Text via DOI: 10.1158/1078-0432.ccr-0297-3 PMID: 15014013

2004

Surfaced-Enhanced Laser Desorption/Ionization Time-of-Flight (SELDI-TOF) Differentiation of Serum Protein Profiles of BRCA-1 and Sporadic Breast Cancer. ANNALS OF SURGICAL ONCOLOGY. 11:907-914.

Full Text via DOI: 10.1245/aso.2004.03.557 PMID: 15383419

2004

The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 22:337-343.

Full Text via DOI: 10.1016/j.urolonc.2004.04.008 PMID: 15283893

2003

A Look at Mass Spectral Measurement. CHANCE. 16:24-28.

Full Text via DOI: 10.1080/09332480.2003.10554871

2003

A novel approach toward development of a rapid blood test for breast cancer.. Clinical breast cancer. 4:203-9.

Full Text via DOI: 10.3816/cbc.2003.n.026 PMID: 14499014

2003

Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response. The Journal of biological chemistry. 278:37736-37744.

Full Text via DOI: 10.1074/jbc.m301649200 PMID: 12842897

2003

Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and Regulation of Tumor Necrosis Factor- Expression. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 95:1846-1859.

Full Text via DOI: 10.1093/jnci/djg118 PMID: 14679154

2003

Proteomics in Health and Disease.. Journal of Biomedicine and Biotechnology. 2003:215-216.

Full Text via DOI: 10.1155/s1110724303002997 PMID: 14615628

2003

SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers.. Disease Markers. 19:229-38.

Full Text via DOI: 10.1155/2004/759530 PMID: 15258337

2003

The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells. VIROLOGY. 305:229-239.

Full Text via DOI: 10.1006/viro.2002.1642 PMID: 12573569

2002

Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients.. CLINICAL CHEMISTRY. 48:1835-43.

PMID: 12324514

2002

Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry.. CLINICAL CANCER RESEARCH. 8:2541-52.

PMID: 12171882

2002

Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men.. CANCER RESEARCH. 62:3609-14.

PMID: 12097261

2001

Properties of Two EBV Mta Nuclear Export Signal Sequences. VIROLOGY. 288:119-128.

Full Text via DOI: 10.1006/viro.2001.1057 PMID: 11543664

2001

Proteomic approaches to biomarker discovery in prostate and bladder cancers.. PROTEOMICS. 1:1264-70.

Full Text via DOI: 10.1002/1615-9861(200110)1:10<1264::aid-prot1264>3.0.co;2-r PMID: 11721637

2000

Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets. JOURNAL OF VIROLOGY. 74:2351-2364.

Full Text via DOI: 10.1128/jvi.74.5.2351-2364.2000 PMID: 10666266

1999

Development of a Transgenic Mouse Model for HTLV Neurological Disease. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.

1999

HTLV-I Tax and Loss of Genetic Integrity. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.

1999

Stimulation of the G1 to S Phase Transition and T-cell Proliferation by the Tax Protein of HTLV-1. Molecular Pathogenesis of HTLV: A Current Perspective. Ed. Hammarskjold, M L. Vandemere Press.

1999

Analysis of potential phosphorylation sites in human T cell leukemia virus type 1 Tax. Journal of Biomedical Science. 6:206-212.

Full Text via DOI: 10.1007/bf02255904 PMID: 10343169

1998

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes. The Journal of biological chemistry. 273:6698-6703.

Full Text via DOI: 10.1074/jbc.273.12.6698 PMID: 9506967

1998

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat. JOURNAL OF VIROLOGY. 2615-2629.

Full Text via DOI: 10.1128/jvi.72.4.2615-2629.1998 PMID: 9525578

1998

Mta Has Properties of an RNA Export Protein and Increases Cytoplasmic Accumulation of Epstein-Barr Virus Replication Gene mRNA. JOURNAL OF VIROLOGY. 72:9526-9534.

Full Text via DOI: 10.1128/jvi.72.12.9526-9534.1998 PMID: 9811685

1998

The Epstein-Barr Virus Lytic Transactivator Zta Interacts with the Helicase-Primase Replication Proteins. JOURNAL OF VIROLOGY. 72:8559-8567.

Full Text via DOI: 10.1128/jvi.72.11.8559-8567.1998 PMID: 9765394

1997

Divergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization. Journal of Biomedical Science. 4:229-234.

Full Text via DOI: 10.1007/bf02253422 PMID: 12386384

1997

HTLV-I tax and cytokeratin: Tax-expressing cells show morphological changes in keratin-containing cytoskeletal networks. Journal of Biomedical Science. 4:47-53.

Full Text via DOI: 10.1007/bf02255593 PMID: 11725133

1996

HTLV-I and HTLV-II Tax: Differences in Induction of Micronuclei in Cells and Transcriptional Activation of Viral LTRs. VIROLOGY. 217:373-379.

Full Text via DOI: 10.1006/viro.1996.0126 PMID: 8599225

1996

Human T-cell Leukemia Virus Type I Tax Masks c-Myc Function through a cAMP-dependent Pathway. The Journal of biological chemistry. 271:9730-9738.

Full Text via DOI: 10.1074/jbc.271.16.9730 PMID: 8621651

1996

Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles.. JOURNAL OF VIROLOGY. 70:6347-6357.

Full Text via DOI: 10.1128/jvi.70.9.6347-6357.1996 PMID: 8709263

1995

Interaction of Tax with CREB requires intact zinc-finger. JOURNAL OF VIROLOGY.

1995

Proliferation of a murine IL-2-dependent cell line to measure altered Il-2 receptor function induced by tunicamycin and sialidase. Receptor Research Methods. Ed. Greenstein, D. Harwood Academic Publishing.

1995

Definition of a minimal activation domain in human T-cell leukemia virus type I Tax.. JOURNAL OF VIROLOGY. 69:1827-1833.

Full Text via DOI: 10.1128/jvi.69.3.1827-1833.1995 PMID: 7853523

1995

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein.. JOURNAL OF VIROLOGY. 5806-11.

PMID: 7637025

1993

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function. VIROLOGY. 456-459.

Full Text via DOI: 10.1006/viro.1993.1145 PMID: 8438579

1992

HTLV-I tax is a zinc-binding protein: Role of zinc in tax structure and function. VIROLOGY. 188:754-764.

Full Text via DOI: 10.1016/0042-6822(92)90530-3 PMID: 1585646

1992

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins.. JOURNAL OF VIROLOGY. 66:7183-7192.

Full Text via DOI: 10.1128/jvi.66.12.7183-7192.1992 PMID: 1433511

1992

Tunicamycin inhibits function and expression of the high-affinity IL-2 receptor in a murine IL-2-dependent cell line. International Journal of Immunopharmacology. 14:583-593.

Full Text via DOI: 10.1016/0192-0561(92)90119-6 PMID: 1521926

1990

HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. SCIENCE. 247:1082-1084.

Full Text via DOI: 10.1126/science.2309119 PMID: 2309119

1986

Influence of tunicamycin, sialidase and cholera toxin on gangliosides and T-lymphocyte responses to Interleukin 2. Federal Proceedings.

1985

C-terminal deletion analogs of a crustacean pigment-dispersing hormone. Peptides. 6:1051-1056.

Full Text via DOI: 10.1016/0196-9781(85)90427-9 PMID: 3841733

1985

Characterization of a pigment-dispersing hormone in eyestalks of the fiddler crab Uca pugilator. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 82:5319-5322.

Full Text via DOI: 10.1073/pnas.82.16.5319 PMID: 16593589

1985

Substitution of norleucine for methionine residues in a crustacean pigment-dispersing hormone. Peptides. 6:491-494.

Full Text via DOI: 10.1016/0196-9781(85)90115-9 PMID: 3840888

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